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Biomedical subjects

M G Wilson

Publications and source records attributed to M G Wilson.

154 records · Page 9Linked to original sources
PubMedDate not supplied

Computer-assisted quantification of periaxial bone rotation from X-ray CT.

PURPOSE: Numerous orthopedic disorders involve periaxial rotation of long bones. We have developed and evaluated a computer-assisted method that segments a bone from X-ray CT, graphically unwraps the bone around its long axis into a surface plot (signature landscape), and measures periaxial rotation as the translation shift of the landscape. Bones in known rotations and partially segmented surfaces were used, respectively, to test accuracy and problematic situations in bone segmentation. METHOD: CT images of three chicken femora at known rotations were analyzed to determine their relative periaxial rotations, which were compared with the known rotations. RESULTS: The regression slope between measured and expected periaxial rotations was 1.005 +/- 0.003, with a maximum discrepancy of 2 degrees for same-bone and 3 degrees for interbone comparisons. Rasterization artifacts and the use of partial surfaces (with < 40% surface omission) resulted in a < 3 and < 1 degree error, respectively. CONCLUSION: The current method provides accurate and objective periaxial rotation measurements of a long bone.

Animals↗
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A rare 6q11+ heteromorphism: cytogenetic analysis and in situ hybridization.

A rare variant of 6q11+ heteromorphism was found in a fetus and the mother during amniocentesis. The G- and Q-banding and DA/DAPI stain were negative. The C-banding was positive and the C-banded segment was 3-fold longer in the variant than in its homologue. Neither of the C-banded regions of chromosomes 6 decondensed when exposed to distamycin A or 5-azacytidine. A DNA replication study indicated that the C-banded variant was late replicating. The lateral asymmetry observed in the 6q11 variant after one replication cycle in 5-bromodeoxyuridine may result from an unequal interstrand distribution of thymidine in the repetitive DNA. Fluorescent in situ hybridization using a chromosome-6-specific alpha-satellite probe (D6Z1) demonstrated hybridization signals on the centromere of chromosome 6. The 6q11 variant showed a signal which was 3-fold larger than its homologue. These results indicate that the 6q11 variant is an amplification of a chromosome-6-specific alpha repeat, and the size of the hybridization signal correlates with the size of the laterally asymmetric and C-banded region.

Amniocentesis↗
PubMedDate not supplied

Tablet-breaking ability of older persons with type 2 diabetes mellitus.

PURPOSE: The purpose of this study was to assess the ability of older persons with type 2 diabetes to accurately break in half 2 different formulations of micronized glyburide tablets. METHODS: Thirty persons with type 2 diabetes, over age 70, were recruited from the St Louis University geriatric clinics. Participants were randomly assigned to 2 groups. Group A broke 30 Glynase Prestabs and 30 generic tablets using 2 different manual tablet-breaking methods. Group B broke 15 Glynase Prestabs and 15 generic tablets without instructions. Visual analog scales were used to assess pain and difficulty of tablet breaking. RESULTS: A higher percentage of successful tablet breaking was reported with Glynase Prestabs (80%) compared with the generic tablets (33%). Mean pain scores for breaking Glynase Prestabs were 0.1 (Group A) and 0.9 (Group B). Higher pain scores were obtained for the generic tablets (2.1 for Group A, 3.2 for Group B). Glynase Prestabs were easier to break in both groups, and the resultant half tablets showed less variance from the expected theoretical weight (50% of whole parent tablet weight). CONCLUSIONS: Older adults broke Glynase Prestabs more accurately and with less difficulty than generic micronized glyburide tablets. This variation in ease of tablet breaking and accuracy between different tablet formulations affect bioavailability and patient compliance.

Administration, Oral↗
PubMedDate not supplied

A comprehensive review of the effects of worksite health promotion on health-related outcomes.

PURPOSE: This article provides the foundation for a series of literature reviews that critically examine the effectiveness of worksite health promotion programs. This issue reviews the exercise, health risk appraisal, nutrition and cholesterol, and weight control literatures; a future issue will review the alcohol, HIV/AIDS, multicomponent program, seat belt, smoking, and stress management literatures. METHODS: The literature search used a four-step process that included a computerized database search, a reference search, a manual search of relevant health promotion journals, and the writing of the review by a recognized expert in the area being searched. The databases were searched from 1968 through 1994 and included Medline, Aidsline, Psychological Abstracts, Combined Health Information Database, Employee Benefits Infosource, National Prevention Evaluation Research Collection, National Resource Center on Worksite Health Promotion, National Technical Information Service, and the Substance Abuse Information database. A total of 288 articles were identified by the search, not including the 37 articles in the hypertension literature. Authors of each review were requested to incorporate additional studies not identified by the search, provide a research rating for each individual article, and a rating for the overall literature for their respective area. The authors reviewed 316 studies. FINDINGS: The overall ratings for the reviews reported in this issue were suggestive for exercise, weak for health risk appraisals, suggestive/indicative for both nutrition and cholesterol, and indicative for weight control. The ratings for the other reviews will be reported in the subsequent issue. CONCLUSIONS: Research reported in these reviews suggests the effectiveness of worksite health promotion programs, however, additional research is required to provide conclusive evidence of their impact.

Health Knowledge, Attitudes, Practice↗
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The health effects of worksite HIV/AIDS interventions: a review of the research literature.

PURPOSE: To examine the individual and organizational health effects of HIV/AIDS interventions conducted at the worksite. SEARCH METHODS: This review is part of a series of reviews that used search methods described in an introductory article. To supplement these methods, HIV/AIDS-specific periodicals were searched to include journals that might not be incorporated in the computerized databases. Twelve of the 20 articles identified through the Centers for Disease Control and Prevention and our own subsequent searches met the criteria and were included in this review. FINDINGS: Ten of the 12 studies reviewed reported positive effects of employee education programs on knowledge or attitudes. Nine of the studies involved health care workers or employees with potential occupational exposure to HIV, and nine lacked a comparison or control group. None of the studies however, examined the effects of policies, manager training, or family education on the organization or person. CONCLUSIONS: Methodologic weaknesses in many of the studies reviewed, coupled with the small number of studies, led us to conclude that the research literature on worksite HIV/AIDS interventions is weak. Impact is, however, plausible. Future research should be directed toward developing valid measures of key variables, controlling for confounding factors, and ultimately examining the impact of organizational factors.

HIV Infections↗
PubMedDate not supplied

Health promotion programs in small worksites: results of a national survey.

PURPOSE: This study documents the prevalence of workplace health promotion activities at small worksites with 15 to 99 employees. DESIGN: A random sample of U.S. worksites stratified by size and industry (n = 3628) was drawn using American Business Lists. MEASURES: Each worksite was surveyed using a computer-assisted telephone interview system to document activities related to health promotion and related programs, worksite policies regarding health and safety, health insurance, and philanthropic activities. SUBJECTS: Participation varied by industry and size, with an overall response rate for eligible worksites of 78% for a total sample of 2680 worksites. DATA ANALYSIS: Data were analyzed using SUDAAN statistical software. RESULTS: Approximately 25% of worksites with 15 to 99 employees offered health promotion programs to their employees, compared with 44% of worksites with 100+ employees. As with the larger worksites, the most common programs for worksites with 15 to 99 employees were those related to occupational safety and health, back injury prevention, and CPR. The majority of worksites in both size categories had alcohol, illegal drug, smoking, and occupant protection policies. The majority of both small and large worksites also offered group health insurance to their employees (92% and 98%, respectively), with many of the worksites also extending benefits to family members and dependents (approximately 80% for both business sizes). CONCLUSIONS: The results indicated that small worksites are providing programs to their employees, with a primary focus on job-related hazards. Small worksites also have formal policies regarding alcohol, drug use, smoking, and seatbelt use and offer health insurance to their employees at a rate only slightly lower than that of large worksites.

Female↗
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Factors associated with, issues related to, and suggestions for increasing participation in workplace health promotion programs.

This review examines factors associated with, issues related to, and suggestions for increasing participation in workplace health promotion programs. The purpose is to help health professionals better understand why people participate and how program planners can effect participation. The lack of results and contradictory findings of some studies emphasize the complex nature of participation. Studies have shown that participants are likely to be young with high education and income. Preliminary studies have also shown a relationship between participation and some behavioral and psychosocial variables, although these studies have yet to be confirmed. The participation issues of self-selection and comprehensiveness are discussed. Suggestions for increasing participation are offered.

Age Factors↗
PubMedDate not supplied

Prevalence of hypercholesterolemia in a national worksite sample.

We conducted a screening for serum cholesterol levels at 41 locations of a large manufacturing company to determine baseline serum cholesterol levels in a workplace population. Locations were based on volunteerism. We conducted screenings at the worksite with individuals voluntarily participating on company time. Fifty percent of eligible employees participated in the screening. Using National Cholesterol Education Program guidelines, we identified 17.6% of employees as hypercholesterolemic (greater than or equal to 240 mg/dL), and another 30.2% were at borderline high risk. Total serum cholesterol increased with age and was higher in men than in women. Total cholesterol was significantly associated with age, sex, marital status, and education, but not with occupational status.

Adult↗