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Biomedical subjects

M G Netsky

Publications and source records attributed to M G Netsky.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Melanotic neuroectodermal tumors of the brain and skull.

A case of melanotic neuroectodermal tumor in the cerebellum of a 21-year-old man is presented. Melanin was found mainly in small neoplastic cells rather than in large epithelioid cells. The tumor also contained neurons, as well as neoplastic tissue of ependyma, choroid plexus; and astrocytes. We propose that this neuroectodermal tumor resulted from a combination of cells originating in the neural crest and in the neural tube. The small cells have been described as medulloblasts, but they may be poorly differentiated ependymal cells, or, sympathicoblasts. The presence of pigment in these cells is compatible with an origin in the neural crest. The so-called melanotic progonoma, occurring most often in the maxilla of infants, is reviewed in relation to the melanotic neuroectodermal tumor of the brain. The tumor in facial bone occurs in adults as well as infants, in locations other than the maxilla, and has malignant forms. Melanotic neuroectodermal tumors, whether in brain or bone, are therefore similar in behavior as well as histologic appearance. The finding of similar tumors in these different locations is readily explained embryologically.

Adult↗
PubMedDate not supplied

Intracanalicular neurilemmomas: clinicopathologic study.

Twenty-five patients with intracanalicular neurilemmonas were studied, the largest series yet reported. The tumors were most frequent in men by a ratio of 2:1, occurred more often on the left acoustic nerve, generally associated with long duration of symptoms and were equally distributed in the third to fifth decades, but the prevalence slightly increased in the sixth and seventh decades. A shorter length of illness occurred in younger persons as well as most patients with von Recklinghausen's disease. The length of illness ranged from six months to 35 years. Symptoms generally were limited to the auditory nerve except in three instances of involvement of the facial nerve. These three cases were the only ones with preoperative facial palsy. Posterior fossa myelogram was the most useful diagnostic acid. The rate of growth in one patient was estimated to be 1 to 2 mm per year by serial study of myelograms, but the growth rate is probably variable. CT scans were not useful in detecting small tumors. Histologically, most tumors less than 1 cm in diameter were primarily composed of Antoni type A tissue. Vascular malformations were found within the tumor in three cases. Altered blood vessels are the mechanism whereby characteristic changes occur in the cerebrospinal fluid (CSF). Small tumors generally lack blood vessels, hence are less often associated with abnormal CSF.

Adolescent↗