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Biomedical subjects

M G Hadfield

Publications and source records attributed to M G Hadfield.

At least 55 records · Page 3Linked to original sources
PubMed1980

Neurofibrillary pathology in progressive supranuclear palsy.

We describe the fine structure of the subcortical neurofibrillary tangles (NFT) in 2 cases of progressive supranuclear palsy (PSP). In case 1 (69-year-old man) about one half of the NFT in the midbrain and pons examined were composed of 13-16 nm straight filaments and the other were made up of paired helical filaments (PHF) of Alzheimer type. The NFT in case 2 consisted of straight tubules with infrequent segments of unusual twisted fibril of unknown nature. The simultaneous occurrence of straight and PHF in one of these cases suggests that the NFT in PSP may be similar to those of Alzheimer type occurring in various conditions.

Aged↗
PubMed1978

Association of central pontine myelinolysis and Marchiafave-Bignami disease.

Combined pathologic features of central pontine myelinolysis and Marchiafava-Bignami disease occurred in a 53-year-old man with chronic alcoholism. This association is rare despite the basic similarities of these two disorders. The combination of both conditions in the same patient suggests a common pathogenetic mechanism.

Alcoholism↗
PubMed1977

The pathology of Sandhoff's disease.

We have presented the morbid anatomy of a case of Sandhoff's disease and have attempted to outline morphologic differences which distinguish this entity from other GM2 gangliosidoses. Yet, it may be well to maintain a sceptical eye. The anatomic differences among Tay-Sachs disease and its variants are more quantitative than qualitative and are overshadowed by the similarities. For these reasons, a definitive diagnosis must rest with the biochemist. Nevertheless, if many bizarre MCB's are encountered, the enzyme defect may be expected to differ from that of classical Tay-Sachs disease and, when seen in endothelial cells, they favour Sandhoff's disease. More importantly, if prominent visceral storage is found, and especially if it extends beyond the reticuloendothelial system to involve such selective sites as the kidneys and pancreas, Sandhoff's disease should immediately come to mind. For the pathologist, it is this latter point which more readily sets apart Sandhoff's disease from related GM2 gangliosidoses.

Brain↗
PubMed1976

The protein composition of bovine myelin-free axons.

The proteins of axons prepared from myelinated axons and isolated as myelin-free entities were separated by sodium dodecyl sulfate polyacrylamide electrophoresis and found to consist of more than 10 different molecular weight species. The molecular weights range from 13 000 to over 200 000 with a prominent protein of molecular weight 47 000. The amino acid composition of the seven major proteins showed that the protein with a molecular weigt of 47 000 is distinct from all the other proteins analyzed. A group of three low molecular weight proteins have amino acid compositions which are similar to each other as do a group of three high molecular weight proteins although the two groups are distinctly different from each other and the major axonal protein. Histones, DNA, myelin basic protein and glycoprotein were absent from the proteins but neurotubule protein was present as indicated by cochicine binding activity in the axonal preparations. The cellular origin of these proteins and their relationship to other central nervous system proteins are discussed.

Amino Acids↗
PubMed1976

Alterations of liver and spleen following intravenous infusion of fluorocarbon emulsions.

Mice were injected via tail vein with emulsions of fluorocarbon (FC), an oxygen-carrying compound that has great potential as a blood substitute. Different types of FCs were used. All produced vacuolar changes in hepatocytes, and in reticuloendothelial cells throughout the body. In the liver, occasional inflammatory foci were also observed, but fibrosis was never seen. The vacuolated cells, presumably containing FC, were found as late as one year following a single infusion. However, such cells might also disappear from the liver and spleen. The numbers of affected cells and their rate of disappearance depended on the type of FC, the amount of FC infused, the length of time between infusion and killing. Fluorodecalins, especially PP-5, produced the least amount of change and the most readily reversible change of all FCs tested. The morphologic observations suggest that PP-5 would be more suitable as a blood substitute than the other FCs tested. However, other studies have shown that apparently healthy long-term survival is obtainable even when the infused FC is one that produces extreme vacuolar change in the liver and spleen.

Animals↗
PubMed1975

Dural sinus occlusion in leukemia.

The case of a 7-year-old child with acute lymphocytic leukemia who, while in relapse, developed a superior sagittal sinus thrombosis is documented by angiography and post-mortem examination. Review of the literature suggests that cerebral spinal fluid (CSF) pleocytosis which usually accompanies the arachnoid infiltration of central nervous system (CNS) leukemia may be absent in some patients as in this case. In the absence of CSF pleocytosis, cerebral venous sinus thrombosis may mimic the other signs and symptoms of CNS leukemia and consequently may be a more frequent complication of acute leukemia than is presently appreciated. Therapy directed to the CSF axis generally would not under these circumstances be appropriate.

Brain↗