Frequency-modulated responses from urinary bladder on stimulation of telencephalic & diencephalic centres.
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Biomedical subjects
Publications and source records attributed to M G Gogate.
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The interrelationship between Feeding and Hoarding of food pellets was observed to be disrupted following bilateral destruction of lateral septal nuclei in adult male albino rats. The significance of forebrain areas and neuro-endocrinal connection to hypothalamus is discussed.
The pattern of activity obtained in rats on a regimen of one hour access to food and water was compared to the activity pattern seen when immobilization stress was added to the same regimen. Food and water were provided at the same time of the day. Immobilization stress decreased the body weight, increased the time taken for grooming, maintaining at the same time the food intake. The water intake also increased significantly but the alcohol intake was variable, 3 of the rats showing an increased intake while the rest showed a decreased intake under this stress regimen. The pattern of activity changed from hyper-activity during food restriction alone to increased activity restricted to the first half of the testing time during added immobilization.
Autonomic responses to breath holding were studied in twenty healthy young men. Breath was held at different phases of respiration and parameters recorded were Breath holding time, heart rate systolic and diastolic blood pressure and galvanic skin resistance (GSR). After taking initial recordings all the subjects practised Nadi-Shodhana Pranayama for a period of 4 weeks. At the end of 4 weeks same parameters were again recorded and the results compared. Baseline heart rate and blood pressure (systolic and diastolic) showed a rendency to decrease and both these autonomic parameters were significantly decreased at breaking point after pranayamic breathing. Although the GSR was recorded in all subjects the observations made were not conclusive. Thus pranayama breathing exercises appear to alter autonomic responses to breath holding probably by increasing vagal tone and decreasing sympathetic discharges.
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Rats were fed with food of different caloric densities by addition of kaolin or groundnut oil to the normal food powder. The food intake, caloric intake and body weights were noted. These observations were compared before and after bilateral destruction of mid-dorsal caudate nucleus. The food intake before caudatal lesion varied appropriately with the caloric density of food thus maintaining caloric intake and body weight. After mid-dorsal caudatal destruction this feedback mechanism of maintaining body weight was operative with low caloric density diet but not with high caloric diet.
Though relative dominance of photic/non-photic cues on rodent circadian running activity is known, the exclusive role of non-photic entrainers in rats deprived of photic entrainers is not demonstrated and hence present work using retino-hypothalamic pathway blocked male rats (n = 10) was initiated. Blocking is done by enucleation of eyeballs. Circadian running activity is studied before enucleation and after enucleation towards instinctual social cues, food, water and sexual cues provided in activity cage. Twenty four hour activity of rats was recorded kymographically for a fifteen day period before enucleation and for a similar period after enucleation. Analysis of the records revealed that eight animals had predominant diurnal rhythm whereas two animals had predominant nocturnal rhythm. Enucleation of diurnal rats neither altered total running activity pattern nor caused any significant change in the goal compartments thus showing absence of entrainment by photic cues. In contrast nocturnal rats showed gradual shift of activity towards day time on enucleation thus indicating that nocturnal animals were entrained by photic cues. The overriding influence of non-photic entrainers on photic entrainers is discussed.
Effects of mid-dorsal caudate nucleus on sensorimotor changes were studied in rats. After electrolytic lesion of this area of brain there was impairment in sensory functions and decline in motor component was observed to be statistically significant.