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Biomedical subjects

M G Forest

Publications and source records attributed to M G Forest.

151 records · Page 9Linked to original sources
PubMedDate not supplied

[Proceedings: Effects of metopirone on plasma androgens variations in women (author's transl)].

Blood testosterone (T), androstenedione (A) and dehydroisoandrosterone (DHA) were simultaneously measured, using radioimmunoassay, in six healthy (control) females and eight various subjects, before (J1), during (J2) and after (J3) metopirone administration. The variation pattern of each androgen is different during the test. The mean value of each androgen at each time, point and the percentage decrease between J2 and J3 related to J2 are considered. Each step of the test (increase and decrease) is discussed with reference to published data and variations of response obeserved in the eight non control subjects.

Androstenedione↗
PubMedDate not supplied

[Medroxyprogesterone acetate. Contributive treatment in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency in children].

Among 59 children presenting with congenital adrenal hyperplasia due to 21-hydroxylase deficiency observed between 1976 and 1982, 12 (9 males, 3 females) aged 3 1/2 to 12 years, were treated with medroxyprogesterone acetate (MPA) associated with the usual glucocorticoid and eventually mineralo-corticoid treatment. There were two indications: precocious puberty after the onset of the gluco-mineralo-corticoid treatment; Unbalanced biological status with advancement of bone maturation. After the onset of MPA, a decrease in plasma 17-hydroxyprogesterone (17 OHP) and testosterone levels is observed, the bone maturation speed decreases when growth in height continues. MPA may be a contributive treatment for congenital adrenal hyperplasia due to 21-hydroxylase deficiency, permitting restoration of biological balance by restraining adrenal function and improving the final height prognosis.

Adrenal Hyperplasia, Congenital↗
PubMedDate not supplied

[Value of the assay of urinary gonadotropins in pediatric endocrinology].

An assay for urinary gonadotropins (UG) performed after acetone extraction is presented. This dosage was performed either on a sample of the 24 assay urine, or on the fractionated 12 hr/12 hr urines (night/day) in normal children whose ages ranged from 2 to 20 years and in children presenting with various endocrine diseases (on about 2,000 urine samples). Normal values were established according to sex and stage of puberty. In boys, the lack of overlap between values of LH (UI/24 hr) observed in stage I (prepubescent, 9-13 yrs) and those observed in stage II represents an obvious biological marker of the onset of puberty. The night/day ratio of LH also increases close to puberty, reflecting the onset of the well-known night secretion of LH, at the time of the first stages of puberty. In girls, the preferential increase in FSH is the best criterion for the onset of puberty. In children with endocrine diseases, assay for UG/24 hr is a valuable parameter of the gonadotropic function allowing 1. to separate delayed puberty from hypogonadotropic hypogonadism; 2. to confirm a diagnosis of precocious puberty and 3. to control a treatment with LHRH analogous.

Adolescent↗
PubMedDate not supplied

[Disorders of sexual differentiation in infants and children. Physiopathological studies (author's transl)].

A series of 100 cases is presented : 34 female and 66 male pseudohermaphrodites (MPH). Plasma levels of testosterone (T) and its precursors have been made in basal conditions and in the MPHs after hCG stimulation test. In spite of detailed hormonal, anatomical and chromosomal studies no etiological diagnosis was made in about half the MPHs. In 45% of those, the response to hCG was inadequate suggesting that ambiguous development of the genital ducts, urogenital sinus and external genitalia is associated with a wide spectrum of defective testicular gonadogenesis. The endocrine function of these dysgenetic testes may worsen with age. Determination of T and several of its precursors is essential for the correct diagnosis of inborn errors in testicular biosynthesis which was made thrice by systematic study of so-called simple hypospadias. It is suggested that systematic hormonal study should be made in all children, and preferably newborn, with ambiguous genitalia associated with micropenis or bilateral cryptorchidism.

Child, Preschool↗