Search PubMed⌕ Search

Biomedical subjects

M G Deo

Publications and source records attributed to M G Deo.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Insulin secretion and carbohydrate metabolism in experimental protein malnutrition.

In order to study the evolution of endocrine and metabolic changes in protein malnutrition, we created a replica of this human syndrome in a primate model. This model was free from stress factors like infestations, and infections and provided an opportunity to study the details more closely. Our results showed that definite endocrine and metabolic changes are established by six weeks of protein deprivation. The study demonstrated that protein deprivation results in decreased fasting blood glucose levels associated with diminution in fasting, and total insulin output when presented with a glucose load. There is also deterioration of carbohydrate tolerance. It is suggested that decreased fasting blood glucose is a consequence of impaired breakdown and/or depletion of glycogen stores, and hepatic dysfunction secondary to fatty infiltration. The exact cause of decrease in insulin output remains to be clearly elucidated. The carbohydrate intolerance is attributed to insulin lack, hepatic dysfunction and decreased glucose disposal consequent to protein deprivation.

Animals↗
PubMedDate not supplied

Androgenic status of lepromatous leprosy patients with gynecomastia.

The androgenic status of 24 lepromatous leprosy male patients, 12 with and 12 without gynecomastia, was studied in comparison with that of 12 normal healthy males. Plasma testosterone levels were significantly diminished in the gynecomastia group as compared to levels in either of the control groups. The patients without gynecomastia showed values not significantly lower than those of normal males. Histopathologic examination of the leprous testes showed a variable admixture of inflammatory, degenerative anf fibrotic changes which were more severe and more frequent in the patients with gynecomastia than in those without it. Parenchymatous liver function tests showed greater derangement in the gynecomastia group as compared to the controls Histopathology of the liver showed lepromatous infiltration in patients with and without gynecomastia though the changes in liver were minimal in patients who showed total testicular degeneration in the biopsies.

Adolescent↗