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Biomedical subjects

M G Davey

Publications and source records attributed to M G Davey.

At least 37 records · Page 2Linked to original sources
PubMed1976

Routine freezing of red blood cells for transfusion in Western Australia.

Experience with preservation of red cells for transfusion since 1971 has shown that refrigeration with liquid nitrogen is simple and reliable. It allows the use of a concentration of glycerol (20%) which can reasonably be removed by batch-washing if automated washing is not possible. It is possible to transport cells frozen in liquid nitrogen over long distances. This appears the method of choice for preserving rare blood, and once adopted for this purpose it is logical to use it for storage of red cells for other patients. Red cells so stored are similar in many respects to fresh cells, and more than 600 units have been transfused since 1971 without any adverse reaction.

Australia↗
PubMed1975

Prevention of rhesus immunization in Australia. The first seven years.

After seven years' general use of anti-Rh (D) immunoglobulin in Australia, it is clear that the rate of Rh immunization by pregnancy can be reduced to 1% or less by giving anti-D to women at risk soon after delivery. All Rh-negative women who have miscarriages or terminations of pregnancy should also be given anti-D. The Australian standard dose of 250 mug of anti-D is also much more than the minimum effective dose for most cases, and few more failures would occur if it were reduced to 100mug of antibody. Some of these may be prevented by screening maternal blood for the presence of fetal cells and giving further anti-D when large numbers are found. A trial has been conducted since 1970 to discover whether giving anti-D during pregnancy as well as at delivery will further reduce the rate of rhesus immunization. Results are still inconclusive. While giving anti-D during pregnancy appear to have no serious hazard for mother or infant, it will prevent few cases of rhesus immunization, and may not be justifiable. There has so far been little change in the incidence or mortality of haemolytic disease of the newborn in Australia that cen be attributed to the use of anti-D.

Abortion, Spontaneous↗
PubMed1973

Infectious mononucleosis complicated by acute haemolytic anaemia with a positive Donath-Landsteiner reaction.

A patient with infectious mononucleosis complicated by acute haemolytic anaemia is described. The patient had, in addition to non-specific cold agglutinins in the serum, a positive Donath-Landsteiner reaction in the absence of syphilis. The association of a positive Donath-Landsteiner reaction with haemolytic anaemia in infectious mononucleosis has been described only once before.

Adolescent↗
PubMed1969

The isolation of a component of the venom of Trimeresurus okinavensis that causes the aggregation of blood platelets.

1. A substance has been isolated from the venom of the Okinawan pit viper (Trimeresurus okinavensis) that causes the aggregation of human blood platelets. The reaction resembles that between platelets and thrombin or connective tissue, in that the platelets release ADP. 2. The purified venom fraction is a protein-polysaccharide, and after Pronase digestion had mol.wt. 4x10(6), containing 10% peptide, 85% neutral sugars and 5% hexosamines. It is distinct from the proteolytic, esterolytic and coagulant materials also present in the venom, and has not been shown to possess any enzymic activity. How it reacts with platelets is not yet known.

Adenine Nucleotides↗