Proceedings: Distribution of radioimmunoassayable gastrin, secretin, pancreozymin and enteroglucagon in rat, dog, and baboon gut.
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Animals↗
Biomedical subjects
M G Bryant
Publications and source records attributed to M G Bryant.
Abundance of VIP in duodenal mucosa of coeliacs and duodenal ulcer patients.
VIP levels were determined in gastroduodenal mucosal biopsies of 8 duodenal ulcer patients, of 5 coeliac sprue patients, and of 8 volunteers without upper gastrointestinal disease. In duodenal ulcer patients, mucosal VIP concentrations were significantly elevated in the proximal duodenum (e.g., in the duodenal bulb 225 +/- 48 versus 95 +/- 17 pmol/g in controls), while in coeliac sprue VIP levels tended to be increased in the whole duodenum and upper jejunum (e.g., descending duodenum 409 +/- 161 versus 81 +/- 16, p less than 0.05). In both disease entities, the rise in mucosal VIP may be a reaction of the peptidergic nervous system to chronic mucosal irritation and a reason for enhanced fluid and electrolyte secretion in the affected areas.
Adult↗
Vasoactive intestinal polypeptide in the pituitary pars nervosa.
Vasoactive intestinal polypeptide (VIP) is a widely distributed neuropeptide which has recently been found in the hypothalamus and in hypothalamo-hypophyseal portal blood. We have examined the pituitary of several mammalian species for the presence of VIP by immunocytochemistry and radioimmunoassay and report here that the pars nervosa contains a considerable quantity of VIP (100-250 fmol/mg) which, in the dog, can be shown to be present in nerve fibres. It is possible that neurohypophyseal VIP may be a local releasing agent for vasopressin.
Adult↗