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Biomedical subjects

M G Bousser

Publications and source records attributed to M G Bousser.

At least 271 records · Page 15Linked to original sources
PubMed1981

[Polyradiculoneuritis associated with plasmocytoma. Recovery following radiotherapy (author's transl)].

A new case of extensive subacute polyradiculoneuritis associated with a costal plasmocytoma secreting IgG lambda is reported. Radiotherapy of the rib, resulted in remarkable neurological improvement and haematological cure, which have now persisted for more than 5 years, though treatment was discontinued 3 years ago. By its distinctive haematological features, this case illustrates the lack of clear-cut distinction between "solitary" plasmocytoma and multiple myeloma. It also emphasizes the need for systematic testing for plasma cell proliferation when confronted with a subacute or chronic neuropathy of obscure origin.

Adult↗
PubMed1981

Noninvasive tomographic study of cerebral blood flow and oxygen metabolism in vivo. Potentials, limitations, and clinical applications in cerebral ischemic disorders.

The non-invasive continuous inhalation technique of C15O2 and 15O2 coupled with positron emission tomography (PET) provides brain images that are thought to represent local cerebral blood flow (CBF) and oxygen extraction fraction (OEF). Experimental studies in baboons have confirmed that C15O2 inhalation allows tomographic measurement of CBF. The numerous difficulties involved in PET absolute quantitation are stressed, as well as some limitations inherent to the 15O inhalation model. However, the values for local CBF, OEF and CMRO2 obtained in normal young subjects are satisfactory in view of the above-mentioned limitations. The clinical application to recent cerebral infarction has allowed two opposite types of flow-metabolism uncoupling to be identified, which appear to be often predictive if tissue prognosis. The time course of spontaneous changes in CBF and OEF within the infarct is also described. Our studies have, in addition, revealed the previously unknown phenomenon of "crossed cerebellar diaschisis" in supratentorial infarction. Lastly, a state of chronic watershed ischemia, potentially reversible by surgical revascularization, has been identified as presumably involved in the progression of watershed necrosis. The clinical potentials of this method appear considerable.

Adolescent↗
PubMed1981

[Oculomotor nerve nucleus syndrome: report of two clinical cases (author's transl)].

Two clinical cases are reported of similar oculomotor disorders presenting as a paralysis of the oculomotor nerve (III) on one side and isolated paralysis of the superior rectus on the other side. Previous reports of this clinical picture have not been found. Recent experimental studies have established that all the superior rectus motoneurons decussate and pass through the opposite II nucleus before entering the radicular portion. Therefore it is suggested that the reported syndrome results from an unilateral lesion in the III nucleus.

Female↗
PubMed1981

[Transient loss of consciousness in ischaemic cerebral events. A study of 557 ischaemic strokes and transient ischaemic attacks (author's transl)].

A study was done of 31 episodes of transient loss of consciousness occurring at the onset of 557 cerebral ischaemic events selected on the basis of a well known mode of onset, excluding prolonged comas. The following conclusions can be drawn: Transient loss of consciousness is uncommon in ischaemic strokes (6.5 p. cent), occurring twice as often in cardiac emboli (13.2 p. cent) as in a atherothrombotic brain infarction (6.2 p. cent), and more often in carotid (8.4 p. cent) than in vertebro-basilar (5.7 p. cent) territory. The incidence is however similar in both territories (4.6 p. cent and 4.8 p. cent) when epilepsy is excluded. Epilepsy accounts for nearly half (3.8 p. 100) of all losses of consciousness in hemispheric strokes, but was encountered neither in lacunar strokes nor in transient ischaemic attacks (T.I.A.). Transient loss of consciousness is uncommon in basilar TIAs, and extremely rare in lacunar strokes (1.5 p. 100) and in carotid TIAs (0 p. 100). Presumed mechanisms and practical implications are discussed.

Aged↗
PubMed1980

[Cerebral venous thrombosis, complication of the nephrotic syndrome (author's transl)].

The occurence of arterial and, more frequently, venous thrombosis in patients with the nephrotic syndrome is well documented. Several factors are involved among which the fall in plasma albumin, the rise of several coagulation factors, platelet hyperreactivity, decrease of antithrombin III. We report here the first case, to our knowledge, of a dural sinus thrombosis, complicating a nephrotic syndrome with minimal glomerular changes. The difficulties of such a diagnosis and the key value of carotid angiography to establish it are emphasized. The use of anticoagulants can prevent this complication.

Cerebral Angiography↗
PubMed1980

[Gamma-heavy chain disease with autoimmune abnormalities and peripheral neuropathy (author's transl)].

The authors report the case of a 72 year old woman affected by gamma heavy chain disease in whom the heavy chain was detected in the serum and the urine as well. Further study of the paraprotein showed that it belonged to the gamma 1 subclass. This observation was unusual because of the presence of a 15 year-long peripheral neuropathy and the existence of various auto-antibodies, especially intrinsic factor antibody.

Aged↗
PubMed1980

[Cerebral venous thrombosis in Behçet's disease (author's transl)].

Two patients with Behcet's disease and angiographically demonstrated cerebral venous thrombosis are described. Dural sinuses were involved in one patient and an internal cerebral vein in the other. Cerebral venous thrombosis was the first manifestation of the disease and occurred in the absence of other signs of "Neuro-Behçet". The outcome was favorable. The unusualness of such localisations, their unknown mechanism, and difficulties in their diagnostic and treatment are emphasized.

Adult↗
PubMed1980

[Migraine or transient ischemic attacks in a patient with essential thrombocythaemia. Treatment with ticlopidine (author's transl)].

Ischemic cerebrovascular symptoms occuring in patients with essential thrombocythaemia are usually attributed to platelet or platelet-fibrin emboli. A patient is described in whom transient ischemic attacks (TIA) had some features - namely the presence of headache and the progressive onset of symptoms - unusual for an embolic phenomenon but suggestive of a migrainous event. No further attack occured when the patient was treated by an antiplatelet drug ticlopidine, though platelet count was unchanged. The relationship between platelets, TIA and migraine are discussed.

Blood Platelets↗
PubMed1979

Perhexiline maleate and peripheral neuropathy.

Peripheral neuropathy has been noted as a complication of therapy with perhexiline maleate, a drug widely used in France (and in clinical trials in the United States) for the prophylactic treatment of angina pectoris. In 24 patients with this complication, the marked slowing of motor nerve conduction velocity and the electromyographic changes imply mainly a demyelinating disorder. Improvement was noted with cessation of therapy. In a few cases the presence of active denervation signified a poor prognosis, with only slight improvement. The underlying mechanism causing the neuropathy is not yet fully known, although some evidence indicates that it may be a lipid storage process.

Adult↗