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Biomedical subjects

M G Avdeeva

Publications and source records attributed to M G Avdeeva.

10 recordsLinked to original sources
PubMed1997

[Relationship between cytochemical activity of leukocytes and autorosette formation phenomenon and its clinical significance in patients with leptospirosis].

The content of autorosettes in the peripheral blood forming from red cells round neutrophils and monocytes was found increased during the acute period of icterohemorrhagic leptospirosis. Autorosette-forming cells are characterized by a high activity of alkaline and acid phosphatases and low NBT-test values. The content of autorosettes directly correlates with the disease severity, bilirubin level, and presence of anemia. Assessment of autorosette-forming cells in patients with leptospirosis may be used as an additional test for evaluating the severity of intoxication, disease course, and for predicting the complications and disease outcome.

Acid Phosphatase↗
PubMed1997

[The importance of myoglobin in the pathogenesis of leptospirosis].

Measurements were made of serum and urine myoglobin in 48 patients with leptospiral jaundice (LJ) and 56 patients with various acute infections. At the height of LJ blood myoglobin level reached 28.96 +/- 4.3 micrograms/l (normal concentration 0.315 +/- 0.002 microgram/l). Compared to acute pneumonia, acute viral hepatitis, tonsillitis, erysipelas, diphtheria, health values, the ratio of serum myoglobin to urine myoglobin in leptospirosis made up 45.25 against 5.4, 4.8, 6.8, 3.7, 1.8 and 1.3, respectively. A relationship was found between concentrations of myoglobin, bilirubin, creatinine in the blood and leptospirosis severity. Elevation of serum myoglobin as a manifestation of specific myositis is pathognomic for leptospirosis and contributes to the onset of acute renal failure and disturbance of bilirubin metabolism. Quantitation of blood myoglobin may be helpful as an additional test for leptospirosis severity.

Adolescent↗
PubMed1997

[Leukocyte chromatin anisotropy in patients with leptospirosis].

Chromatin anisotropy is measured and its correlation with the cytochemical activity of leukocytes estimated in 19 patients with icterohemorrhagic leptospirosis. Leukocyte and neutrophil nuclei chromatin anisotropy increases during the acute period of leptospirosis, indicating an increase of cuchromatization and transcription activity. Neutrophil nuclei euchromatization is observed in patients with all forms of leptospirosis irrespective of the disease severity. Lymphocyte nuclei euchromatization is observed only in the patients with a favorable course but not in those with the severe course of the disease. Correlations between neutrophil and lymphocyte nuclei euchromatization and cytochemical activity of lymphocytes and monocytes are detected. The optic anisotropic effect is proposed to be used as an extra diagnostic criterion of leptospirosis severity.

Adult↗
PubMed1989

[Modifications of cytochemical methods of detecting alkaline and acid phosphatase activities of leukocytes].

Wide use of the detection of the leukocytic alkaline and acid phosphatase (AIP and AP) activities by the azo coupling method has necessitated the development of rational modifications of the routine methods. When staining just few smears, it is recommended that the neutrophilic AIP activity be detected by applying the incubation medium onto the filter paper covering the blood smear; such a modification, used for the staining of 1-6 blood smears, reduces the reagent consumption by 5-6 times and is time-saving. The modification of the method for the detection of the leukocytic AP activity involves the use of the diazole blue O stain manufactured in this country; the acetate-veronal buffer (containing sodium diethylbarbital) is replaced by citrate buffer, pH 6.4. The leukocytic AIP and AP activities, determined in the blood smears stained according to the suggested and routine methods, coincide (p greater than 0.05).

Acid Phosphatase↗
PubMedDate not supplied

[Prognostic significance of the NBT test in patients with ichterohaemorrhagic leptospirosis].

The values of spontaneous NBT test significantly rise at the peak of leptospirosis in patients with an uncomplicated course of the disease (p < 0.05). Low values of the spontaneous NBT test with stimulation with Staphylococcus in patients with grave leptospirosis predict the development of life-threatening complications. Leptospirosis vaccine reduced the elevated values of the NBT in leptospirosis. The depressing effect of leptospirosis vaccine is indicative of a high risk of development of late complications.

Adolescent↗
PubMedDate not supplied

[Study of acid lability of DNA in patients with leptospirosis].

Measurements of DNA and study of chromatin status in blood cell nuclei help solve numerous basic problems of biology and medicine. Acid lability of DNA was assessed in 5 patients with grave icterohemorrhagic leptospirosis. The distribution of fluorescence peaks on the curve of neutrophil DNA hydrolysis in patients with grave leptospirosis indicates that functionally low-active acid-resistant DNA fraction predominates in their chromatin. Assessment of acid lability of DNA is proposed to be used for assessing the severity of the pathological process.

Acids↗
PubMedDate not supplied

[Adhesive intercellular interactions].

The process of intercellular interactions during morphogenesis, inflammation and malignant growth are considered from the point of view of possible intercellular contacts provided by cell adhesion molecules. The system analysis of different cell adhesion molecules classes? their structure and influence on functional cell activity is performed. Clinical importance of expression disturbances of cell adhesion molecules at various pathological processes is considered.

Cell Adhesion↗