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Biomedical subjects

M G Anderson

Publications and source records attributed to M G Anderson.

At least 73 records · Page 4Linked to original sources
PubMed1983

Recurrent meningitis due to round-window fistula in Klippel-Feil syndrome. A case report.

Hearing is impaired in 30% of patients with Klippel-Feil syndrome, owing to a variety of anatomical deformities of the inner and middle ear cavities. Recurrent meningitis due to a stapedial footplate fistula associated with this syndrome is rare. A case of Klippel-Feil syndrome, deafness and recurrent meningitis due to a round-window fistula is described. Surgical sealing of the defect prevented further meningeal infections.

Cochlea↗
PubMed1981

Enzyme-linked immunosorbent assay (ELISA) for antibodies to human myelin and axolemma-enriched fractions.

The Enzyme-Linked Immunosorbent Assay (ELISA) is a well established procedure for antibody determination which has gained wide acceptance, particularly in diagnostic virology. We have adapted the method for use with the lipid rich antigens of human myelin and axolemma enriched fractions. Adsorption of the antigen onto the assay plates was rapid and relatively independent of pH. Antibodies to myelin and axolemma cross-reacted extensively. Little antibody reaction was noted using human liver microsomes, indicating the antibodies were specific but that myelin and axolemma shared at least one strong common antigen. With further purification of the antigen, this method should be useful in evaluating immunogenicity and antigenic purity of these membrane fractions.

Animals↗
PubMed1979

Prothrombin time after heparin removal. Application to monitoring simultaneous anticoagulation with heparin and coumarins.

Coumarin-anticoagulated plasmas from 31 subjects comprising two study groups were passed through epichlorohydrin triethanolamine cellulose (ECTEOLA) chromatography columns. Group I plasmas, which were run with nothing added, had mean prothrombin times of 21.6 +/- 5.4 sec prior to and 22.4 +/- 5.6 sec following exposure to these columns (r = 0.9449; t = 1.8307, P less than 0.100). The mean prothrombin time for Group II, 18.2 +/- 4.9 sec, lengthened with 5 u/ml heparin to 35.5 +/- 16.2 sec, and returned to 19.2 +/- 5.0 (r = 0.9763) after chromatography. Therefore, it appears that coumarin anticoagulation had no significant influence upon the capacity of ECTEOLA effectively to remove heparin in therapeutic doses. This means that virtually all prothrombin time reagent systems can be employed to monitor concurrent heparin and coumarin anticoagulation. In addition, quality control of the combined technic is simpler, and the technic more sensitive to low levels of fibrinogen and factor V.

Cellulose↗
PubMed1977

Biochemical and physiological effects of catecholamine administration in the horse.

Adrenaline was given intramuscularly to resting horses. It increased heart rate, sweating, blood levels of lactic dehydrogenase, aldolase, creatine kinase, glucose, lactate, free fatty acids and glycerol. Responses to isoprenaline, to noradenaline and to adrenaline after pretreatment with propranolol indicated that beta receptors were involved in stimulation of tachycardia, sweating, lipolysis and muscle glycogenolysis, and alpha receptors in stimulation of liver glycogenolysis and leakage of intracellular enzymes. The time course and relative magnitude of the effects on different enzymes was not identical to that produced by exercise.

Animals↗
PubMed1976

The effect of exercise on the lactic dehydrogenase and creatine kinase isoenzyme composition of horse serum.

The distribution of lactic dehydrogenase, aldolase and creatine kinase in various horse tissues was determined. Using polyacrylamide gel electrophoresis the lactic dehydrogenase and creatine kinase isoenzyme composition of horse serum, taken before and after exercise, was studied. Horse tissue isoenzyme patterns were also obtained. By comparing tissue and serum patterns, skeletal muscle was found to be the tissue of origin of the increase in serum lactic dehydrogenase and creatine kinase observed after exercise.

Animals↗
PubMed1975

Aberrant left pulmonary artery: a rare cause of congenital stridor.

Aberrant left pulmonary artery is a rare cause of stridor and respiratory difficulty in infancy and childhood. Diagnosis can be made on oesophagram, and is confirmed conclusively on angiography. Surgery can be curative, especially in cases without severe associated cardiovascular anomalies. A case report is presented of the condition occurring in a South African Black infant.

Esophageal Stenosis↗
PubMed1975

The effect of exercise on blood metabolite levels in the horse.

The effects of exercise of different intensities on blood concentrations of glucose, lactate, pyruvate, free fatty acids and glycerol were studied in a group of clinically normal horses. Blood lactate, pyruvate and lactate/pyruvate ratio increased during exercise, particularly during galloping. These changes occurred within the first 12-15 seconds of exercise indicating that anaerobic metabolic pathways are brought into use very quickly in the strenuously exercising horse. Since blood glycerol levels were significantly increased during exercise body lipids were also mobilised. At the same time, free fatty acid levels increased during cantering but decreased during galloping indicating increased fat oxidation during strenuous exercise. It was concluded that both lipids and carbohydrates are as important energy sources in the exercising horse as in other species.

Animals↗