[Hormonal bases for the psychoemotional status of lactating women].
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Adrenocorticotropic Hormone↗
Biomedical subjects
M G Aliev
Publications and source records attributed to M G Aliev.
[Hyperplasia of the thymus gland in children: physiology or pathology?].
A critical analysis of the literature data and of the results of clinicoroentgenological, hormonal and immunological studies in children with thymomegaly makes it possible to regard hyperplasia of the thymus gland at early childhood as a sign of functional incompetence of the thymus and of the secondary immunodeficient state.
Adrenal Insufficiency↗
[Effect of chronic stress during pregnancy on the thyroid status of mother and progeny].
The effect of chronic stress (electric stimulation) in the second half-period of pregnancy on the status of the hypophyseothyroid system of mother and her progeny was studied. Experiments were staged on 100 pregnant rats and their progeny aged 20 days, 1, 2, 3 and 6 mos. The content of thyroxine (T4), triiodothyronine (T3) and thyrotropic hormone (TTH) in the blood of mother (in the midterm and at the end of pregnancy) and progeny was determined by a radioimmunoassay. Chronic stress during pregnancy led to a decrease in the level of thyroid hormones by the end of pregnancy, the decrease being more significant than that in controls. In the progeny of experimental rats higher T4 content (as compared to that in controls) was accompanied by a lowered level of T3 indicating a decrease in the metabolism of thyroid hormones. These changes were most noticeable at early stages of development but were preserved till puberty. Thus chronic stress during pregnancy led to a decrease in the content of thyroid hormones in the mother's blood, an increase in thyroid function of progeny, and a decrease in its general thyroid status.
Animals↗
[Effect of chronic stress during pregnancy on the functional state of the hypothalamo-hypophyseo-adrenal system in the progeny].
A study was made of the effect of a chronic stress on the activity of the hypothalamo-hypophyseo-adrenal system in pregnant rats as well as on the development of its function in the progeny in postnatal ontogenesis. Experiments were made on pregnant Wistar rats and their progeny. A chronic stress in the 2nd half of pregnancy has been shown to have a detrimental effect on function of the hypothalamo-hypophyseo-adrenal system not only of pregnant animals but also of their progeny, particularly in early periods of postnatal development. In prenatally stressed animals a delay in the development of the monoaminergic system of the hypothalamus was observed which, in its turn, had an effect on the level of the main adenohypophyseal hormones (ACTH, STH and prolactin).
11-Hydroxycorticosteroids↗
[Simulation of thymus hypo- and hyperplasia by thymalin in guinea pigs].
Potentialities of the modulation of thymus function with thymalin and the hormonal-immunological status in simulated hypo- and hyperplasia of the thymus. The advisability of the use of the drug was shown.
Adrenal Cortex↗
[Serum lipoprotein levels and milk secretion in different ruminants].
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Animals↗
[Characteristics of adenohypophseal secretory activity in children with thymomegaly].
The radioimmunological method was applied in the study of ACTH, STH, and prolactin content in thymomegaly combined with pneumonia, and in practically healthy children. A comparative analysis of hormonal parameters depending on the functional condition of the thymus demonstrated a directly proportional correlation between the STH, prolactin level, and the thymus hyperplasia; there proved to be a reverse relationship between the ACTH level and thymomegaly. Hypoadrenocorticotropinemia, hypersomatotropinemia, and hyperprolactinemia could be used as diagnostic criteria in thymomegaly.
Adrenocorticotropic Hormone↗
[Changes in the function of the hypothalamo-hypophyseo-adrenal system and the thymus as affected by corticotropin in guinea pigs].
Functional state of the hypothalamic-hypophyseal-adrenal system and the thymus was studied in thymic hypo- and hyperplasia of guinea pigs. It was detected that thymomegalia is accompanied by STH and prolactin hyperproduction in adeno-hypophysis, intensified lymphopoiesis (at the expense of T-lymphocytes) and the adrenal glucocorticoid function inhibition, resultant of the lowered ACTH secretion, as well as by the enhanced catecholamine and serotonin content in the hypothalamus. Reverse changes are seen in thymic hypoplasia following intramuscular ACTH injection in a dose 1 U/kg/day within 5 to 10 days.
Adrenocorticotropic Hormone↗
[Hormonal and immunological status of children with thymus hyperplasia].
The state of the adrenocortical system, cellular and humoral immunity was studied in 152 infants, suffering from thymomegaly, associated with virus-bacterial pneumonia. The results obtained allow one of to consider the hormonal and immunological state of the patients with thymomegaly to be inhibited and the adrenocortical hypofunction to be secondary. Therefore, the infants with thymomegaly should be separated into a special "risk" group, according to their immunodeficient states, respiratory allergies, acute and chronic adrenocortical deficiency.
11-Hydroxycorticosteroids↗