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Biomedical subjects

M Fujii

Publications and source records attributed to M Fujii.

At least 721 records · Page 40Linked to original sources
PubMed1986

[Randomized crossover trial of the antiemetic effects obtained with metoclopramide and droperidol versus those obtained with metoclopramide, droperidol and methylprednisolone in patients receiving cis-platinum chemotherapy].

Twenty-four patients with lung cancer receiving cis-platinum chemotherapy were entered in an antiemetic randomized crossover trial. The effects of high-dose metoclopramide and droperidol (regimen I) were compared with those obtained with a combination of high-dose metoclopramide, droperidol and methylprednisolone (regimen II). Three patients (12.5%) treated with regimen I and 10 (43.5%) treated with regimen II had no vomiting at all (p less than 0.05). Patient preference was significantly in favor of regimen II (p less than 0.05). No Severe side effects were observed. A further trial is necessary to determine the optimal dosage and scheduling of the available agents.

Aged↗
PubMed1986

[Two cases of intussusception of appendiceal mucocele: diagnostic value of preoperative ultrasonography].

Mucocele of the appendix was first described and named "Hydrops processus vermiformis" by Rokitansky in 1866. Intussusception of a appendiceal mucocele is very rare and we have been able to find only 14 previously reported cases. We present two cases with preoperative ultrasonography which is valuable for its diagnosis. Case 1: A 5-year-old male was admitted to Kahoku Hospital because of right lateral colic abdominal pain and tumor. Ba-enema examination revealed intussusception to the colon and ultrasonography showed the cystic mass of the appendix. Case 2: A 51-year-old female was admitted because of right lower abdominal pain. Ultrasonography was helpful showing the cystic tumor at the base of the appendix. Recent reports say that ultrasonography is valuable examination for its diagnosis. Also in our two cases preoperative ultrasonography was performed and gave us valid information for its qualitative diagnosis.

Appendix↗
PubMed1986

The phosphorothioite method. Synthesis of deoxyoligonucleotides on polymer supports by using nucleoside phosphorothioites.

The development of a new method, which is called "the phosphorothioite method", for synthesizing deoxyoligonucleotides on polymer supports is described. Nucleoside phosphorothioites were easily prepared and readily activated by iodine or silver acetate. In the case of the use of iodine, the present method did not require the oxidation step, because it could be simultaneously performed during condensation and thereby the reaction time could be shorten. This method was applied successfully to the polymer support synthesis.

Base Sequence↗
PubMed1986

Plasma concentration and peritoneal clearance of oxalate in patients on continuous ambulatory peritoneal dialysis (CAPD).

Accumulation of oxalate, resulting in high plasma levels, is a common finding in end-stage renal disease. We investigated plasma concentration and peritoneal clearance of oxalate in 14 patients on continuous ambulatory peritoneal dialysis. The plasma oxalate levels in these patients (30.2 +/- 11.2 mumol/l) were as high as those in hemodialysis patients before dialysis (31.9 +/- 11.1 mumol/l). There was a significant correlation between plasma oxalate and urea nitrogen appearance (UNA). Dietary protein seems to be an important oxalate source in these patients, because the UNA reflects protein intake in stable patients. The mean peritoneal oxalate clearance was 6.64 +/- 1.56 l/day, close to the creatinine clearance. These results suggest that the plasma oxalate levels in CAPD patients may be sufficiently high to induce calcium oxalate deposition, and that methods of increasing oxalate removal and reducing oxalate burden are necessary for CAPD patients.

Adolescent↗
PubMed1986

[Efficacy of a latex Foley catheter with sustained release of chlorhexidine: 1st report: Clinical trials for the prevention of urinary tract infection].

Seventy five patients requiring urethral catheterization for over 24 hours were treated with a latex Foley catheter with sustained release of chlorhexidine in a closed drainage system. While the catheter was indwelling, urinary concentrations of chlorhexidine were maintained at the level of 1 to 2 micrograms/ml in average in almost all patients. The catheter was highly effective in preventing the acquisition of catheter-associated bacteriuria in patients with initially sterile urine without systemic antimicrobial therapy. The acquisition rate of bacteriuria was 8, 16, 23, 35 and 74% on day 3, 4, 5, 6 and 7 with the catheter indwelling, respectively. The catheter was not effective in eradicating preexisting bacteriuria. Complications of the catheter were minimal.

Adult↗
PubMed1986

[A case of asthma attack induced by high-dose metoclopramide].

A 39-year-old woman was admitted to our hospital for further investigation of an abnormal shadow on chest X-ray film. The chest X-ray film showed mass shadow in the right upper lung field and multiple nodular shadows in the whole lung. Histologic examination of a bronchofiberscopy biopsy specimen revealed bronchioloalveolar carcinoma. A combination chemotherapy with cis-platinum and vindesine was started. After high-dose metoclopramide (2 mg/kg) administration for the prevention of cis-platinum-induced nausea and vomiting, laryngeal obstructive sensation, stridor and expiratory dyspnea appeared. After metoclopramide was stopped, and aminophylline injected, symptoms began to disappear slowly. The above symptoms developed again following a provocation test of high-dose metoclopramide. Arterial blood gas analysis showed hypoxemia. We concluded that the asthma attack in this patient was caused by high-dose metoclopramide therapy.

Adult↗
PubMed1986

[Intrapleural chemotherapy with cisplatin and adriamycin in lung cancer with carcinomatous pleuritis].

Seventeen patients with lung cancer who had malignant pleural effusion were intrapleurally treated with cisplatin and adriamycin. According to Koyama and Saito's criteria, ten patients showed complete response, four partial response and three no change. The overall survival from the beginning of treatment was 6.0 months (2.6+ -21.4 months). The survival in patients with complete response and performance status 2 + 3 was better than that in patients with partial response and performance status 4, respectively. Toxicities were minimal. The pharmacokinetics of intrapleural non-protein-bound platinum showed a mean half-life of 20.45 hours. Intrapleural chemotherapy with cisplatin and adriamycin thus seems to be an effective modality for lung cancer with carcinomatous pleuritis.

Aged↗
PubMed1986

[Abdominal Burkitt's lymphoma developing the tumor lysis syndrome following chemotherapy].

A 16-year-old girl was referred to our hospital complaining of a huge abdominal mass and ascites. Cells from the ascites were morphologically compatible with Burkitt's cells. These cells had surface immunoglobulin (gamma and kappa chain) and were positive for B-cell monoclonal antibody (L21, 24). Small numbers of the same cells were present in the bone marrow. Soon after the beginning of chemotherapy, oliguria, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia caused by "tumor lysis" developed. Peritoneal dialysis was not effective, and the patient died of acute renal failure. Autopsy revealed no tumor cells in her body.

Abdominal Neoplasms↗
PubMed1986

[Clinical experience of methylcobalamin (CH3-B12)/clomiphene citrate combined treatment in male infertility].

Infertile men (excluding azoospermia) were divided into three groups to test methylcobalamin (CH3-B12) + clomiphene citrate (Clomid) treatment. Group M: CH3-B12 (1,500 micrograms/day, daily for 8 to 60 weeks), Group C: Clomid (25 mg/day for 25 days followed by a 5-day rest period, for 8 to 48 weeks), and Group MC: CH3-B12 + Clomid (CH3-B12: 1,500 micrograms/day, daily and Clomid: 25 mg/day for 25 days followed by a 5-day rest period, for 12 to 24 weeks semen analysis was conducted before and after these administrations. Judging by our criteria, 60.0% (24/40) of the cases in Group M, 71.4%(25/35) in Group C, and 66.7% (8/12) in Group MC were improved. However, in patients whose sperm concentrations were over 10 X 10(6)/ml, 61.9% (13/21) of the cases in Group M, 69.2% (9/13) in Group C, and 80.0% (4/5) in Group MC were improved. Therefore, CH3-B12 + Clomid treatment was successful for patients whose sperm concentrations was over 10 X 10(6)/ml.

Adult↗