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Biomedical subjects

M Fuchs

Publications and source records attributed to M Fuchs.

303 records · Page 17Linked to original sources
PubMedDate not supplied

Alpha-adrenergic vasoconstriction in arterial and arteriolar sections of the canine coronary circulation.

Using a method which allowed the in-situ measurement of segmental coronary vascular resistances, the reaction of arterial and arteriolar sections of the coronary vascular system to alpha-receptor stimulation was studied i anaesthetized dogs. The left coronary artery was cannulated, and the perfusion pressure was kept constant. Allowance was made for extravascular and metabolic influences of alpha-stimulation on coronary vascular resistances. On an average, submaximal alpha-stimulation with xylometazoline increased the arterial resistance by about 60% and the arteriolar resistance by about 90%. The cannulation of the left coronary artery increased the sympathetic reactivity of the arterioles. Moreover, xylometazoline increased the extravascular component of the coronary vascular resistance by about 4%. Thus it can be assumed that under normal in-vivo conditions alpha-receptor vasoconstriction might be less different in coronary arteries and arterioles. Since the arterial resistance ranges from 20% to 50% of total coronary resistance, a sympathetic vasoconstriction of this vascular section might lead even to a critical limitation of coronary blood flow. On the other hand, a predominant constriction in arterioles leads to an increase in peripheral coronary pressure, i.e. to a "reverse coronary steal phenomenon".

Animals↗
PubMedDate not supplied

Influence of the ischemic coronary bed on collateral blood flow.

The purpose of this study was to determine the influence of the resistance of the terminal vascular bed of an occluded coronary artery on collateral blood flow and collateral resistance. In 6 anesthetized dogs, left anterior descending coronary artery (LAD) was ligated, cannulated, and the terminal vascular bed was occluded by latex microspheres (diameter: 25 mu). Retrograde flow was measured using a new technique, which allowed control of outflow pressure of retrograde flow (PRF) at the LAD cannula. When retrograde flow was interrupted, pressure in the occluded vessel represented collateral perfusion pressure (CPP) within the border zone of the ischemic vessel. Collateral resistance was determined dividing the pressure difference across the collateral bed (CPP-PRF) by retrograde flow. Variation of PRF was used as a model for changes in resistance of the ischemic bed. Retrograde flow fell when PRF was increased from 11.0 +/- 3.0 ml X min-1 X 100 g-1 (PRF = 0) to 8.3 +/- 2.4 (p less than 0.01)(PRF = 24.6 +/- 6 mm Hg). For the same PRF range, collateral resistance fell from 9.68 +/- 2.96 to 8.30 +/- 2.50 mm Hg X ml-1 X min X 100 g (p less than 0.01). These results indicate that the vascular resistance of the terminal ischemic bed may considerably influence collateral blood flow and resistance.

Animals↗
PubMedDate not supplied

Incidence of major congenital malformations in offspring of alcoholics and polydrug abusers.

The incidence of major congenital malformations was compared in the offspring of mothers who abused alcohol only (group I), versus mothers who abused alcohol and opiates (group II) during pregnancy. In group I the percent of patients with malformations was 33, where as in group II it was 14. The prevalence of fetal alcohol syndrome was higher in blacks than Hispanics. Independent of race the alcohol-opiate combination seems less teratogenic to the fetus than alcohol alone.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[Migraine and its treatment through functional relaxation].

In contrast to externally manifest behaviour modification, this report deals with the detection and dissolving of unperceptible, unconscious by maladjusted behaviour in patients suffering from headache. This procedure is oriented towards the patient's own personal rhythm, thereby attempting to achieve a balance between relaxation and tension. In the event that unconscious control of the diaphragm by means of relaxation is achieved, it is possible to simultaneously influence the neurovegetative balance. This is crucial for patients with vasomotor cephalalgia. The significance of disturbances in early childhood relations and increase in self-awareness, self-conficence, and self-assurance is demonstrated with the case history of a five year old girl who had suffered severe migraine and was treated successfully by crisis intervention with functional relaxation.

Child, Preschool↗