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Biomedical subjects

M Friedman

Publications and source records attributed to M Friedman.

824 records · Page 46Linked to original sources
PubMedDate not supplied

Needle aspiration of metastatic melanoma.

Needle aspiration of nodal and extranodal metastases of malignant melanoma was evaluated in 74 patients. All patients had the initial diagnosis of malignant melanoma established on surgical biopsy and histologic sections. A 20-cc glass syringe and an 18-gauge needle were used, and the material obtained was stained by the Wright-Giemsa technique. Adequate material was obtained, and a cytologic diagnosis of malignant melanoma was made in 67 patients (90.5%). In seven patients (9.5%) the specimens contained nondiagnostic material. The diversity of cell types, cytoplasm staining affinity and pigmentation is described. Despite the high variability of the cytologic features encountered, malignant melanoma usually can be diagnosed on cytologic smears. Difficulties in recognizing the nonpigmented varieties are emphasized. The procedure was well tolerated, and no complications were seen.

Biopsy, Needle↗
PubMedDate not supplied

The cytology of metastatic balloon cell melanoma.

We describe the cytologic presentation in fine needle aspirates of two examples of metastatic balloon cell melanoma. These hypervacuolated cells may be misinterpreted as adenocarcinoma or liposarcoma. Intermediate forms between the classic nonvacuolated round melanoma cell and the ballooned melanoma cell are described.

Adult↗
PubMedDate not supplied

Inter- and intra-laboratory variability in rat growth assays for estimating protein quality of foods.

Protein efficiency ratio (PER), relative PER (RPER), net protein ratio (NPR), relative NPR (RNPR), and nitrogen utilization (NU) methods were investigated in an interlaboratory rat growth study. Six collaborating laboratories studied 7 protein sources (ANRC casein; minced beef; soya assay protein, SAP; pea flour; whole wheat flour, WW; rapeseed protein concentrate, RPC; and egg white solids, EW), and their 10 supplementary or complementary mixtures (casein + Met, SAP + Met, pea flour + Met, WW + Lys, WW + casein, WW + beef, WW + SAP, WW + pea flour, WW + RPC, WW + EW). Test protein(s) were added at the 8% level (N X 6.25). Casein + Met was used as the reference protein. Interlaboratory variation (estimated as between-laboratories coefficients of variation) of PER (up to 17.2%) was greater than that of RPER (up to 14.9%), NU (up to 9.5%), NPR (up to 7.0%), and RNPR, which had the lowest variability (up to 4.7%). In most cases, intralaboratory variation (estimated as within-laboratories coefficients of variation) for all the methods was less than 5%.

Animals↗
PubMedDate not supplied

Parathyroid adenoma diagnosed as papillary carcinoma of thyroid on needle aspiration smears.

Needle aspiration of a neck mass was performed on a 55-year-old white female with hypercalcemia. The cytologic material showed cohesive clusters of monomorphic hyperchromatic cells resembling follicular cells. Papillary formation and follicle-like arrangements suggested papillary carcinoma of the thyroid. The histopathologic section of the excised mass, however, revealed a parathyroid adenoma. The diagnostic difficulties in differentiating parathyroid adenoma from well-differentiated thyroid carcinoma are discussed. Data published in the literature emphasize similar difficulties, and it is concluded that a final diagnosis can be established only on histopathologic sections.

Adenoma↗
PubMedDate not supplied

Pulmonary microangiography. A comparison of in vitro versus in vivo perfusion techniques in dogs.

Because of a need to correlate pulmonary microvascular changes with physiologic data during lung injury, in vitro and in vivo pulmonary capillary microangiography was performed on normal dogs and those subjected to oleic acid injury and glass bead microembolization. During these studies, no significant differences were found between microangiograms obtained after in vitro and in vivo perfusion techniques. This work therefore suggests that in vitro microangiography yields reliable morphologic information more conveniently than more expensive and difficult in vivo techniques. In vitro pulmonary capillary microangiography can provide reliable structural information which can be correlated with physiologic data.

Angiography↗
PubMedDate not supplied

Diagnosis of chronic lymphocytic thyroiditis (nodular presentation) by needle aspiration.

Needle aspiration was performed on 40 patients with a diagnosis of chronic lymphocytic thyroiditis, and the cytologic findings are described. Clinically, 32 patients had a nodular lesion or lesions, and 8 had diffuse enlargement of the thyroid. A 20-ml glass syringe and an 18-gauge needle were used to aspirate the lesions, and smears were stained according to the Wright-Giemsa technique. Diagnostic material was obtained in 36 patients, and in 4 the aspirate was unsatisfactory. There was good correlation between cytologic findings and antibody tests. Thirteen patients underwent surgical excision of the lesions, and the diagnosis was confirmed histologically. In one patient, the histopathologic diagnosis was chronic lymphocytic thyroiditis and thyroid adenoma. The latter component was not recognized initially on the cytologic specimen. The abundant cellular material obtained in the early nodular forms may correspond to a cellular phase of the disease as opposed to a later fibrotic phase. The evaluation of the epithelial-lymphoid ratio is stressed, and substantial alteration of this ratio may suggest an association of chronic lymphocytic thyroiditis with other thyroid lesions, benign or malignant.

Adolescent↗
PubMedDate not supplied

A portable datalogger to evaluate recall-based time-use measures.

Self-completed recall diaries have become a common tool in epidemiology and exposure assessment to determine the location and/or activities of subjects during study periods. Unfortunately, little effort has been made to determine the accuracy of such an approach for providing information without significant bias. It is usually assumed that subjects are truthful and complete in their recall. An electronic datalogger has been designed to allow subjects to record location changes as they occur in real time. Subjects carried the datalogger for 3-5 days and completed recall diaries at the end of each day. The concordance between the two records was found to be relatively good for the most commonly visited locations, e.g., bed/bath, workplace, etc. Poorer agreement was found for locations of short or infrequent visits, e.g., cellar or vehicle. The merits and shortcomings of the datalogger approach are discussed. While having external validation for recall diary records is clearly necessary, reliance on subject input to the datalogger presents its own problems related to subject compliance. Electronic approaches which do not require active subject input are recommended to aid in the evaluation of recall diaries.

Data Collection↗