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Biomedical subjects

M Frey-Wettstein

Publications and source records attributed to M Frey-Wettstein.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Tetanus antibody screening in blood donors].

Two ELISA test methods for detection of tetanus antibodies are presented which are suitable for routine screening. Administration of the tests to blood donors shows good average immunization of the Swiss population against tetanus. Due to compulsory immunization during military service, men exhibit markedly higher antibody levels against tetanus than women. Some of the tested blood donors have rather high tetanus antibody titers, and it would be worth collecting plasma from these donors by plasmapheresis for production of a high-titred antitetanus hyperimmunoglobulin.

Adult↗
PubMed1979

[Anti-D hyperimmunoglobulin, a study of Swiss requirements].

Owing to the introduction of postpartum Rhesus prophylaxis with anti-D hyperimmunoglobulin, a very small number of Rh-negative women become sensitized against the Rhesus factor at birth. Accordingly, the number of naturally immunized women suitable for the collection of anti-D plasma is decreasing. Currently, the demand for anti-D plasma in Switzerland is covered by plasma donations of spontaneously immunized women. The relation between production of and demand for anti-D hyperimmunoglobulin is expected to improve in the coming years due to better registration of anti-D-carrying women. Large areas of Switzerland are poorly exploited with regard to female anti-D donors and represent substantial reserves with regard to anti-D hyperimmunoglobulin production. It is expected that anti-D production from plasma collected from naturally sensitized women will cover demands up to the year 2000 without difficulty. Active immunization of Rh-negative volunteer donors will not be needed before the end of the century.

Erythroblastosis, Fetal↗
PubMed1979

[Pathogenesis of bone marrow necrosis in a patient with cancer].

Bone marrow necrosis was observed in a 23-year-old pregnant woman with severe anemia and thrombocytopenia due to bilateral ovarian carcinoma. After removal of the primary tumors, the hematological findings returned to normal, but the progression of the metastasis lead to respiratory insufficiency and death. The possible mechanisms leading to bone marrow necrosis are discussed. In our case, it could be shown that emboli of tumor cells into the vessels of the bone marrow lead to the necrosis of the marrow. The embolization was temporarily stopped after removal of the ovaries.

Adult↗
PubMed1978

[Erythrocyte concentrates as substitutes of whole blood; changes in transfusion methods in a regional hospital (author's transl)].

In Switzerland the amount of blood donations is determined by the demands for plasma; as a result there is a surplus of erythrocyte concentrates for which more uses should be found. Trials in a regional general hospital proved that these concentrates can be advantageously employed in the field of surgery and anasthesia: due to close cooperation between the clinical department and the blood donor sevice the demand for erythrocyte concentrates rose from 5 per cent to 80 per cent within 5 years.

Blood Transfusion↗
PubMed1977

[Post-transfusion hepatitis 1973 and 1974 in the Zürich region].

More than 100 000 units of blood were tranfused during the years 1973-74 in the region of Zurich. 30 cases of posttransfusion hepatitis (PTH) reported in this period were investigated with regard to the origin of the tranfused blood, and 24 (71%) proved to be hepatitis B antigen (HBS-Ag) positive. Despite the use of a sensitive method for HBS-Ag screening, transfusion of HBS-Ag positive blood was found to be responsible for PTH in 4 cases only. In 88% of the cases there was no proof that the PTH was caused by blood transfusion. Hepatitis A virus, EPstein-Barr virus and Cytomegalovirus do not appear to be important causative factors in PTH syndrome. Reasons for failure to detect hepatitis virus in donor blood are discussed. There appear to be other sources of hepatitis-virus infection than blood transfusion.

Hepatitis↗
PubMed1977

[Hepatitis B antigen (HBSAG) in hospitalized children].

Blood samples of 1940 hospitalized children aged 0--18 years were investigated for presence of HBs-Ag by counter-electrophoresis, haemagglutination and radioimmunoassay, HBs-Ag was found in 1.34% of all patients, being distributed evenly amongst boys and girls. The incidence was 1.7% in patients from a large University children's hospital and 0.6% in patients from a group of regional hospitals. Of 26 samples positive by radioimmunoassay, 1 only was found positive by insensitive counter-electrophoresis. In addition to diseases known to be correlated with HBs-antigenaemia in adults, there was an accumulation of inborn deformities as well as perinatal and neurologic disorders in HBs-Ag positive children. Vertical transmission of hepatitis-B virus from pregnant or nursing mothers to their children could not be found. The incidence of HBs-antigenaemia increases little with age, thus infection in early childhood appears probable at least in a part of the cases.

Abnormalities, Multiple↗
PubMed1976

[Microaggregates in preserved blood].

Today it is generally accepted that microaggregates contained in stored blood may be deleterious to the pulmonary circulation if large volumes of blood are transfused. These microaggregates can be eliminated from blood with the help of microaggregate filters. Such filters are expensive and their efficiency and safety has not been tested thoroughly as yet. Alternatively, the use of microaggregate-free blood is advocated to prevent pulmonary complications in massively transfused patients. Fresh blood, fresh frozen plasma and buffy-coat free red cell concentrates do not contain significant numbers of microaggregates and can be used for massive transfusion without microaggregate filtration.

Blood Platelets↗
PubMed1975

[Proceedings: Transfer factor--a preliminary report].

Experience with the production, physicochemical analysis and clinical application of transfer factor (TF) from 1971 to 1975 is briefly reviewed. Standardized TF preparations were given to over 100 patients in controlled studies. Clinical results are discussed and the present position of TF therapy is evaluated.

Clinical Trials as Topic↗
PubMed1975

[Use of erythrocyte sediments in a regional hospital].

At a medium sized hospital, efforts were made to economize therapeutic use of blood by replacing whole blood by cell concentrates with a hematocrit of 75%. Transfusion of red cell concentrates was increased from 5 to 30% within one year. The number of blood units transfused to individual patients was generally very small and it should therefore be possible to increase the use of red cell concentrates substantially above this figure without creating problems. The clinical advantages of transfusing red cell concentrates containing a negligible amount of plasma are discussed.

ABO Blood-Group System↗
PubMed1975

[Transfer factor. Properties and possible therapeutic applications (author's transl)].

Transfer factor (TF) is a dialysable and ultrafilterable extract from human leukocytes. It contains only substances with a molecular weight of less than 10 000. Several biological activities of TF are so far known. These refer to the transfer of specific cellular immunity from one individual to another and a stimulating effect, probably of an unspecific nature, on the cellular immune system. So far, favorable therapeutic results have been obtained in chronic candidiasis and a few other chronic infectious diseases, in the Wiskott-Aldrich syndrome and possibly also in some special malignant tumors. The small number of treatments does not permit any firm conclusions to be drawn.

Arthritis, Rheumatoid↗