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Biomedical subjects

M Frenkel

Publications and source records attributed to M Frenkel.

120 records · Page 7Linked to original sources

New global communication process in thermodynamics: impact on quality of published experimental data.

Thermodynamic data are a key resource in the search for new relationships between properties of chemical systems that constitutes the basis of the scientific discovery process. In addition, thermodynamic information is critical for development and improvement of all chemical process technologies. Historically, peer-reviewed journals are the major source of this information obtained by experimental measurement or prediction. Technological advances in measurement science have propelled enormous growth in the scale of published thermodynamic data (almost doubling every 10 years). This expansion has created new challenges in data validation at all stages of the data delivery process. Despite the peer-review process, problems in data validation have led, in many instances, to publication of data that are grossly erroneous and, at times, inconsistent with the fundamental laws of nature. This article describes a new global data communication process in thermodynamics and its impact in addressing these challenges as well as in streamlining the delivery of the thermodynamic data from "data producers" to "data users". We believe that the prolific growth of scientific data in numerous and diverse fields outside thermodynamics, together with the demonstrated effectiveness and versatility of the process described in this article, will foster development of such processes in other scientific fields.

Chemistry↗

Progressive hemifacial atrophy (Parry-Romberg disease).

Hemifacial atrophy (Parry-Romberg syndrome) is characterized by slowly progressive atrophy of one side of the face, primarily involving the subcutaneous tissue and fat. The onset is usually in the first two decades. Ophthalmic involvement is common; the most frequent abnormality is progressive endophthalmos with subsequent changes in the palpebral fissure. Pupillary disturbances, heterochromia, uveitis, and restrictive strabismus have also been frequently reported. We describe six cases that manifest a wide spectrum of ocular and systemic findings. They are noteworthy in that all exhibit pigmentary disturbances of the ocular fundus, a finding rarely reported. Another unusual ocular manifestation in one patient was an acquired partial third nerve palsy on the unaffected side.

Adolescent↗

MCOs' woes.

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Cost-Benefit Analysis↗

Patients' rights.

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Employee Retirement Income Security Act↗

Dynamic visual field testing using the Amsler grid patterns.

An economical and time-sparing technique of dynamic visual field testing employing the Amsler grid patterns and the Berens test targets has been developed. This method accurately detected field loss in all 38 patients and all 63 eyes with neurologic defects tested. In a group of 212 glaucomatous eyes, field defects were determined with 97% specificity.

Humans↗

Cavernous hemangioma of the retina. Genetic and central nervous system involvement.

A 1967 report described retinal "telangiectasia" in a brother and sister. The brother also had concurrent immune deficiency with hypogammaglobulinemia. Several reports have since been published on similar retinal vascular lesions, which have been termed "cavernous hemangioma of the retina." In retrospect, it is likely that this sibling pair also had cavernous hemangioma of the retina and brain, and that the hypogammaglobulinemia was an independent problem. Our report provides a 19-year follow-up on three generations of this family. The affected generations support the diagnosis of a phakomatosis having autosomal dominant inheritance. Cavernous hemangioma of the retina is usually a stable disease, but there is a potential risk of intracranial hemorrhage from cavernous hemangioma of the brain. Family members, with and without fundus findings, should therefore undergo computed tomography or magnetic resonance imaging of the brain, because neurosurgical prophylaxis or treatment may be indicated.

Adolescent↗