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Biomedical subjects

M Freedman

Publications and source records attributed to M Freedman.

At least 145 records · Page 8Linked to original sources
PubMed1984

Amnesia after anterior communicating artery aneurysm rupture.

We studied 11 patients with amnesia and personality change after surgical repair of ruptured anterior communicating artery ( ACoA ) aneurysm. CT and clinical evidence suggested that infarction in the territory of the ACoA was responsible for amnesia and personality change. The medial septal nuclei, the paraventricular nucleus of the anterior hypothalamus, and the medial forebrain bundle are the primary areas of potential interest in these cases. Gross infarction in the frontal lobes is not a requirement for the syndrome.

Adult↗
PubMed1983

Macro--creatine kinase 2: a possible marker of gastrointestinal cancer?

Creatine kinase (CK) is an enzyme found in many body organs. It is used clinically in the diagnosis of myocardial infarction. Recently an atypical isoenzyme, macro-CK2, not found in the sera of healthy individuals, has been reported in patients with gastrointestinal malignancies. This study is a report of our findings in serum samples obtained from 200 patients from November 1981 until December 1982. Twenty-eight patients had gastrointestinal complaints but did not have malignant disease. One hundred seventy-two patients had malignancy. Samples of serum were studied for macro-CK2 with a standard laboratory agarose gel electrophoresis technique. The tests were done without knowledge of the patients' diagnoses. The results show no detectable macro-CK2 in sera from patients without malignancy. It was present before operation in nine of 13 patients with colorectal cancer and 16 of 21 patients with metastases from colorectal cancer or gastric cancer. This preliminary study suggests that the presence of macro-CK2 in serum may be an indicator of malignancy of the gastrointestinal tract and in particular of colorectal cancer.

Adult↗
PubMed1982

Functional retrograde amnesia: a quantitative case study.

The memory impairment of a patient suffering from functional retrograde amnesia was assessed both during the amnesic episode and after its termination. The patient's performance on a task tapping semantic memory was nearly identical on the two test occasions, but his performance on a task tapping episodic memory substantially changed across test sessions. Cueing procedures revealed that in spite of the patient's restricted access to episodic memory during the amnesic period, a relatively intact "island" of episodic memories could be uncovered. The distinction between episodic and semantic memory, as well as the relation between organic and functional retrograde amnesia, are discussed in light of the case study.

Adult↗
PubMed1982

Hodgkin's disease in children: treatment results with MOPP and low-dose, extended-field irradiation.

Combined therapy with MOPP and extended-field irradiation for all children with Hodgkin's disease (except those with favorable clinical stage [CS] 1) was effective in disease control. Overall 5-year survival and relapse-free survival rates were 92% and 82%, respectively. Only one of 27 CS 2 and 3 patients has relapsed (median followup, 4.3 years). Two patients in complete remission died of viral infection. The cost-benefit ratio for such treatment remains to be determined. Morbidity was decreased by the omission of staging laparotomy with splenectomy and by reduction in radiation dose and to a lesser extent volume, but it was increased by the addition of MOPP. In such combined treatment, the smallest number of cycles of MOPP, the lowest radiation dose, and the smallest radiation volume that may be used without loss of treatment effectiveness remain to be determined.

Adolescent↗
PubMed1979

Hodgkin's disease in children: treatment with low dose radiation and MOPP without staging laparotomy: a preliminary report.

Twenty-seven children with previously untreated Hodgkin's disease (CS I-2, II-13, III-3, IV-9) were given three cycles of MOPP to induce a remission which was consolidated with extended field radiation (2000--3500 rad) and three cycles of MOPP. Surgical staging was discontinued. Twenty-five of 27 children have not relapsed (range 15+--64+ months; median 39+ months); two children have died, one of uncontrolled Hodgkin's disease and one of acute infection while in complete remission. Actuarial 3 and 5 year survival rates and relapse-free rates are 91%. The merits of this treatment approach are discussed.

Antineoplastic Agents↗
PubMed1979

Videotaping epileptic attacks during stereoelectroencephalography.

Relating the onset of clinical attacks as recorded on a videotape to surface and depth electrographic events improves our ability to define the local or diffuse origin of seizures. In two patients with complex partial seizures, all 14 attacks appeared 3 to 6 seconds after focal discharges began in the amygdala or hippocampus. This meant that the spread of focal electroencephalographic (EEG) paroxysms caused the eventual clinical seizure. In two other patients with 392 generalized seizures and secondary bilateral synchronous paroxysms, a significant number of clinical attacks preceded the first depth or surface electrographic event. This suggested that the attacks originated from brain regions remote from the recording electrodes.

Adult↗
PubMed1978

Analyses of glucans from cariogenic and mutant Streptococcus mutans.

The extracellular, water-soluble and cell-associated, 1 N NaOH-soluble glucans from cariogenic Streptococcus mutans 6715-13 "wild type" (WT) and glucan synthesis-defective mutants with diminished virulence have been quantitatively and qualitatively analyzed by methylation analysis and gel chromatography. The mutants synthesized more of a highly branched alpha-(1 --> 6)-rich extracellular polymer than WT, and some of this glucan was also found to be cell associated in all but one case. WT, in distinction to the mutants, also synthesized a highly branched, alpha-(1 --> 3)-rich, cell-associated polymer. Treatment of these two distinct polymer types with dextranase or an alpha-(1 --> 3)-hydrolyzing enzyme indicated they were composed of both alpha-(1 --> 3) and alpha-(1 --> 6) linkages and of alpha-(1 --> 6) with branches at the 3-position, rather than of separate alpha-(1 --> 3) and alpha-(1 --> 6) homopolymer mixtures. Gel chromatography before enzymatic hydrolysis disclosed a high degree of polydispersity in both glucan classes. After hydrolysis polydispersity was reduced, again without resolution of two glucan populations. These findings suggest that (i) there are two distinct glucan classes, one alpha-(1 --> 3) rich and the other alpha-(1 --> 6) rich in WT, (ii) diminution of virulence in the mutants is probably ascribable to a failure to form the alpha-(1 --> 3)-rich component, (iii) both alpha-(1 --> 6)- and alpha-(1 --> 3)-rich glucans are found in association with the cell, and (iv) both highly branched glucan types are dextranase and alpha-(1 --> 3)-hydrolase sensitive, and methylation analysis and gel chromatography suggest polymers with highly polydisperse molecular weights which contain mixtures of linkage types.

Chromatography, Gas↗
PubMed1977

Ribonuclease activity in renal failure: evidence for toxicity.

The normal level of serum or plasma poly C-avid ribonuclease activity is 1047 +/- 247 U/mL. Serum levels increase proportionately with elevations in serum creatinine, reaching levels of 9,500-35,000 in patients undergoing dialysis. The levels can be normalised by successful renal transplantation but not by dialysis. Purified human urinary ribonuclease, a glycoprotein enzyme similar to the serum ribonuclease, was capable of: 1) inhibiting the incorporation of 3H-thymidine into mitogen-stimulated lymphocytes; 2) inhibiting the proliferation and growth of bone marrow red cell colonies; and 3) adversely affecting the growth and viability of precursor fat cells.

Cell Division↗
PubMed1976

Sonography of the Page kidney.

We used sonography to investigate 3 patients with hypertension owing to a Page kidney phenomenon. In 2 cases a perinephric cystic collection was compressing the kidney, while in 1 case there was a large perinephric organized hematoma. When a Page kidney is suspected in a hypertensive patient sonography is a reasonable next step in the evaluation, after the excretory urogram, and may obviate the need for angiography.

Adult↗
PubMed1976

Patch graft urethroplasty for urethral stricture disease.

The results with 34 cases of patch graft urethroplasties for urethral stricture disease were compared to the results in other series and found to be significantly worse. Various factors that might have influenced the surgical results were analyzed. Patients dilated least frequently had the best results.

Dilatation↗