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Biomedical subjects

M Franke

Publications and source records attributed to M Franke.

At least 73 records · Page 4Linked to original sources
PubMed1978

Effectiveness of topically applied antibiotics on anaerobic bacteria in the pilo-sebaceous duct.

An unspecific cream vehicle containing 1% erythromycin base was applied once a day for 10 days to one side of the forehead of 16 healthy subjects and the same vehicle without the active agent to the other side. Using the same procedure a solution containing 1.19% clindamycin phosphate (corresponding to 1% clindamycin base) and the corresponding unspecific vehicle was administered to another group of 17 healthy males. Prior to the treatment and after the end bacteria were obtained from the pilosebaceous ducts by means of a special sampling technique. Both ointments containing the antibiotics lead to a significant reduction of the bacterial growth in the pilosebaceous ducts regardless of whether evaluation is made of the total bacterial count or of Propionibacteria. Thus, it could be demonstrated that topical application enables some antibiotics to penetrate into the pilosebaceous duct in an adequate concentration to ensure antibacterial effectiveness if a suitable vehicle is used.

Administration, Topical↗
PubMed1978

[The change of the weight of the pineal gland by formalin-fixation (author's transl)].

The weights of 94 human pineal glands were submitted a 3-day-fixation in 10 per cent neutralized formalin, resulting in a loss in weight in one half of the pineal glands and in an increase in weight in the other. After fixation of 4 weeks the difference between actual and initial weight had diminished, only 10.6 per cent of the pineal glands showed a difference larger than +/- 10 per cent. Therefore, the weights of formalin-fixated pineal glands may be used in statistical comparisons. The question why the weights change differently cannot be answered by us.

Adult↗
PubMed1975

Distribution of benorylate in plasma, synovial fluid and tissue in rheumatoid arthritis.

Six patients, not previously treated, with classical seropositive rheumatoid arthritis and highly active synovitis of one or both knee joints were treated with 4 g of 40% benorylate suspension twice daily for a period of 9--14 days prior to synovectomy. Blood samples were taken at scheduled times during administration of the drug. At operation, synovial fluid and tissue samples were taken and their salicylate, paracetamol and benorylate content measured. Plasma levels of salicylate and paracetamol were, in general, significantly higher than the concentration of these metabolites in the synovial fluid. Benorylate was found in the synovial tissues concentrated especially in the highly inflamed synovial villi. It is probable that benorylate and its metabolites penetrate the synovia but further studies are needed to determine if the metabolites are concentrated in the different synovial cell layers in the same way as benorylate itself. It is possible that part of the clinical effect of benorylate is due to its presence in the synovial tissue and that it has a direct effect in vivo on the synovial membrane. It is also possible that the pharmacokinetic properties of benorylate permit it to enter cell layers inaccessible to its metabolites.

Acetaminophen↗
PubMed1975

[Postvacccinal encephalomyelitis after protective antirabic innoculation, combined with polioencephalomyelitis (lyssa?)].

By means of two cases of postvaccinal encephalomyelitis following antirabies vaccination has been demonstrated the meaning of these complications. In one of these cases has been presumed a simultaneous illness of quiet rabies. The difficulty of an aetiological diagnostic by the morphological effigy of the encephalomyelitids has been referred. An improvement of the dispensaire-system and of the diagnostic of complications following antirabies vaccination is postulated.

Adult↗