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Biomedical subjects

M Frank

Publications and source records attributed to M Frank.

At least 253 records · Page 14Linked to original sources
PubMed1978

[Growth and development in normal puberty].

Puberty is a period of life with a great number of closely correlating aspects. For early recognition of pathological puberty, for rational assessment and effective treatment, interrelations and normal course of the stages are to be considered. Early or late appearance of puberty is mainly due to genetic factors. Therefore, the developmental history of the parents is of great importance. Considerable dispersion in the development of pubertal characteristics must be borne in mind. Recording of clinical data and measurements in percentile graphs permits clear and complete demonstration of the individual development pattern and offers immediate judgment of the growth process. Being familiar with the normal developmental stages and growth physiology, particularly growth velocity, and use of known clinical courses as simple techniques allows exact recognition of abnormal events in growth and development. These methods can often replace expensive hormonal assessments.

Adolescent↗
PubMed1978

Uterine luminal prostaglandin F in cycling mares.

Prostaglandin F was measured by radioimmunoassay in uterine flushings of cycling mares on days 4, 8, 12, 14, 16, 18 and 20 post-ovulation. Prostaglandin F was significantly (P less than .05) affected by day of the estrous cycle and reached maximal levels on day 14. Least squares means for days 4, 8, 12, 14, 16, 18 and 20 were: .66, .81, 4.77, 14.31, 5.48, 3.68 and 2.97 ng/ml, respectively.

Animals↗
PubMed1978

Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner height predictions in normal children and in patients with various pathologic conditions.

Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner height predictions at various chronologic ages were compared with final adult height in 56 normal subjects and in 34 patients with abnormal growth pattern (11 with familial tall stature, 7 with idiopathic precicious puberty, 6 with Turner syndrome, and 10 with primordial small stature or Silver-Russell syndrome). The two recent methods (Roche-Wainer-Thissen and Tanner) gave very accurate results and were superior to the Bayley-Pinneau method in normal subjects and in patients with familial tall stature. However, they overestimated adult height grossly in precocious puberty and moderately in Turner syndrome and in primordial small stature. It is concluded that calculations based on coefficients and regression equations obtained from normal children (as in the Roche-Wainer-Thissen and Tanner methods) can only be used in normal children or in patients with normal growth potential under adequate treatment. Calculations based on percentages of adult height (as in the Bayley-Pinneau method) are preferable in conditions in which the growth potential in relation to bone maturation is inherently reduced and cannot be corrected by treatment.

Adolescent↗
PubMed1978

A study of prostaglandin F2alpha as the lutbolysin in swine: IV An explanation for the luteotrophic effect of estradiol.

This study evaluated effects of estradiol valerate on synthesis, secretion and direction of movement of immunoreactive prostaglandin F2alpha (PGF) in swine. Gilts were randomly assigned to provide uterine flushings representing days 11, 13, 15, 17 and 19 of the estrous cycle (three gilts/day). The same gilts then were allowed one estrous cycle for recovery. During the second postoperative estrous cycle they were treated with estradiol valerate (EV) (5mg/day, SC) on days 11 through 15 and uterine flushings again were obtained on the same respective days with the same gilts represented within each day. Total recoverable PGF per uterine horn increased from day 11 (X - 1.98 ng) to day 17 (X = 210.20 ng) and then declined to day 19 (X = 66.20 ng) during the control period. Following EV treatment average total recoverable PGF was the control period. Following EV treatment average total recoverable PGF was 1.9, 4,144.3 and 4,646.7 ng on the same respective days. EV treatment also resulted in maintenance of elevated levels of total protein and acid phosphatase activity in uterine flushings. These data suggest that estradiol may exert its luteotrophic effect by preventing the release of PGF from the uterine endometrium into the uterine venous system (endocrine secretion) while maintaining the movement of endometrial secretions into the uterine lumen (exocrine secretion).

Acid Phosphatase↗
PubMed1978

Preliminary investigation into a new method of assessing the quality of anaesthesia: the cardiovascular response to a measured noxious stimulus.

It is suggested that the autonomic response to noxious stimulation may be measured during anaesthesia. The response may be marked despite considerable depression of cortical activity as measured by the cerebral function monitor. Preliminary results suggest that large doses of narcotic analgesics reduce the autonomic response to noxious stimulation and this may be used as a test to compare the potency and duration of action of narcotic drugs during anaesthesia. It is possible that the measurement of beat-to-beat variation in heart rate may be used to monitor autonomic nervous system activity and, indirectly, the degree of stress during surgery, provided that the efferent limb of the reflex arc remains intact. With the aid of the cerebral function monitor and with an index of reflex response to noxious stimulation it should be possible to monitor the effect of anaesthesia on the central nervous system more precisely.

Alfaxalone Alfadolone Mixture↗
PubMed1978

Effects of 2,4,6-triaminopyrimidine on the electromechanical properties of guinea-pig myocardium.

The effects of 2,4,6-triaminopyrimidine (TAP) were studied in vitro on transmembrane potential and contractility in guinea-pig myocardium. In electrically driven Langendorff-perfused hearts, the addition of 1 and 5 mM TAP produced an initial dose-dependent positive inotropic response with no change in resting tension. The activation process was studied by means of microelectrode and tension recording from isolated electrically driven guinea-pig left atrial preparations. TAP (1-10 mM) produced dose-dependent changes in both electrical and mechanical properties of the tissue. In particular, 1,5 and 10 mM TAP increased the action potential duration by approximately 20, 40 and 60% while also increasing contractile strength by approximately 30, 60 and 90%, respectively. The mechanical effects of TAP were also observed in the presence of 10 muM propranolol. Experiments on catecholamine-restored hearts which were depolarized by potassium indicated that the inotropic action of TAP was associated with slow calcium influx channels. The inotropic effects of TAP were reduced by D600, a calcium antagonistic agent. These data are consistent with a hypothesis that the inotropic actions of TAP result from a decrease in potassium conductance as a result of the inhibition of Ca++-K+ interactions at the inner surface of the myocardial membrane.

Animals↗
PubMed1978

[Hyperosmolar nonketotic diabetic coma. Treatment with continuous low-dose insulin infusion (author's transl)].

We report the case of a boy aged 9 1/2 years with hyperosmolar, nonketotic diabetic coma. He was not known to be diabetic prior to the onset of coma. Pathogenetic aspects of this rare manifestation of juvenile diabetes are discussed. It is dangerous to decrease osmolarity too rapidly during infusion of very hypotonic solutions. Treatment with continuous low-dose insulin infusion may cautiously be tried.

Child↗
PubMed1977

The nucleocytoplasmic distribution of 3-O-methylglucose in the amphibian oocyte.

Ultra-low temperature microdissection was employed to determine the in situ nucleocytoplasmic distribution 3-O-methylglucose in the amphibian oocyte. The nucleocytoplasmic partition ratio, Kn/c, for this non-metabolizable monosaccharide was 1.54 +/- 0.08. The observed asymmetry could be explained by the differential solubility of the solute in the water of the nucleoplasm and the cytoplasm.

Animals↗