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Biomedical subjects

M Frank

Publications and source records attributed to M Frank.

At least 199 records · Page 11Linked to original sources
PubMed1985

Intravenous cholecystography and ultrasonography in the diagnosis of acute cholecystitis. A prospective comparative study.

In a consecutive series of 120 patients with clinically suspected acute cholecystitis, intravenous cholecystography and gray scale sonography were performed for comparative evaluation in a prospective study. Acute cholecystitis was diagnosed in 71 patients and gallstones without signs of acute cholecystitis in 12, while in 37 patients no gallstone disease could be detected. Intravenous cholecystography could not be performed in 28 cases because of jaundice, iodine allergy or pregnancy, and in ten other patients there was no proof of hepatic excretion of the contrast medium. Though the results in the cases with interpretable cholecystograms were excellent, the clinical usefulness was only 68%. Ultrasonography was feasible in all cases and the accuracy was 93%. Ultrasonography has the additional advantages of noninvasiveness and no irradiation problems. Sonographic findings such as thickening of the gallbladder wall, distension, and tenderness on compression of the gallbladder were diagnostically helpful in acalculous cholecystitis and in distinguishing between acute and chronic gallbladder disease. Ultrasonography is recommended as the initial screening procedure in suspected acute cholecystitis.

Acute Disease↗
PubMed1985

One hundred cases of anaesthesia for extracorporeal shock wave lithotripsy.

One hundred cases of anaesthesia for Extracorporeal Shock Wave Lithotripsy (ESWL) are described. Epidural or general anaesthesia was used. Anaesthetic complications were mainly cardiovascular, namely hypotension and bradycardia. With increased experience, it was noted that the use of minimal concentrations of general anaesthetic agents, or epidural anaesthesia supplemented with ephedrine, decreased the incidence of these problems. There was a low incidence of nausea or vomiting or analgesic requirements postoperatively, and the average length of stay in hospital postoperatively was 3 days.

Adolescent↗
PubMed1984

Changes in cerebral electrical activity measured by the Cerebral Function Analysing Monitor following bolus injections of thiopentone.

Seven premedicated patients were anaesthetized with thiopentone administered incrementally every 180 s while cerebral electrical activity was recorded with the Cerebral Function Analysing Monitor (CFAM). Arterial blood samples were collected at 40, 90 and 165 s after each bolus of thiopentone for the measurement of plasma total and bound thiopentone concentrations. The correlation between free thiopentone concentration and the CFAM representation of mean electroencephalogram (EEG) amplitude was -0.78 (P less than 0.001), excluding values following the first two boluses. Beta band percentage activity was inversely related (r = 0.70-0.90; P less than 0.05- less than 0.001) and delta directly related (r = 0.76-0.86; P less than 0.05- less than 0.001) to log of free thiopentone concentration, including all values. The closest correlations (beta, r = 0.88, P less than 0.001; delta r = 0.80, P less than 0.001) were found at 90 s after each bolus.

Adolescent↗
PubMed1984

Comparison of the prophylactic use of magnesium trisilicate mixture B.P.C., sodium citrate mixture or cimetidine in obstetrics.

The effects of magnesium trisilicate mixture B.P.C., sodium citrate mixture or cimetidine on gastric pH and aspirated gastric volumes were compared in 78 obstetric patients during elective (a), or emergency (b) surgery. Magnesium trisilicate mixture B.P.C. was associated with the most alkaline values of gastric pH (mean (a) 7.9, (b) 7.3; range 2.9-9.1). Sodium citrate 0.3 mol litre-1 mixture resulted in the narrowest range of pH values of gastric contents (mean (a) 5.4, (b) 5.9; range 3.9-7.7). The ranges of aspirated gastric volumes were wide with both antacid regimens (magnesium trisilicate 12-172 ml, sodium citrate 9-290 ml). Cimetidine increased gastric pH to greater than 2.5 in 82% of patients (mean (a) 6.2, (b) 5.0; range 1.6-7.3), and was associated with significantly smaller volumes of aspirated gastric contents (range 0.5-44 ml). When gastric pH and volume were considered together, the groups of patients who received cimetidine were found to be closest to the defined "safe limits", of pH greater than 2.5 and volume less than 25 ml.

Anesthesia, Obstetrical↗
PubMed1984

Use of atracurium in caesarean section.

Following induction of anaesthesia with methohexitone, and tracheal intubation facilitated by suxamethonium, atracurium 0.3 mg kg-1 was administered to 53 patients undergoing Caesarean section. Surgical relaxation and cardiovascular stability were good. On completion of surgery, recovery from neuromuscular blockade occurred spontaneously in 45 patients and in the remaining eight patients, neostigmine and atropine produced rapid and effective antagonism. There was no evidence of recurarization in any patient. In the neonates there were no adverse effects on Apgar scores or on the time to sustained respiration attributable to the use of atracurium . The drug concentration in the umbilical vein measured in 15 patients indicated that atracurium did not cross the placenta in amounts likely to be of clinical significance.

Adult↗
PubMed1984

PC emergency.

Explore the source record for details and available documents.

Computers↗
PubMed1983

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.

We have constructed a recombinant bacterial library containing cDNA prepared from mRNA of adipose 3T3 cells. We have screened this library by several methods and isolated colonies containing sequences complementary to mRNAs for glycerophosphate dehydrogenase, two other major differentiation-dependent proteins of Mr = 28,000 and 13,000, and actin. These recombinants were identified by hybrid selection of total adipocyte mRNA, translation in vitro and subsequent immunoprecipitation, and two-dimensional electrophoresis of translated proteins. Three of the four cloned cDNAs hybridized to single adipocyte mRNA species of size close to that expected from the size of the polypeptide it specifies, but the mRNA for glycerophosphate dehydrogenase contained 3,550 bases, far larger than necessary to code for its polypeptide (Mr = 34,000). The increase in amount of mRNA during differentiation was 150-fold for the protein of Mr = 13,000 and considerably greater for glycerophosphate dehydrogenase and the protein of Mr = 28,000. The time course of mRNA accumulation was different for each of these mRNAs, indicating they do not respond synchronously during differentiation.

Adipose Tissue↗
PubMed1983

A simple technique for securing tubes.

The brief task of inserting a tube, such as a central venous catheter or a chest tube, is usually followed by the longer task of ensuring that the tube will not be inadvertently pulled out. Various methods for securing tubes have been described, and yet these tubes continue to be pulled out with frustrating predictability. The author describes a technique for securing tubes which is simple, effective, requires no special equipment or assistance, and which is applicable to any flexible tube or catheter inserted at a site suitable for placement of an anchoring suture. After the anchoring suture is secured to the skin, an easily mastered knot is performed which, because it will not slip when tightened, allows an indentation to be made in the tube. Once this indentation is further secured with a square knot, it will not allow the tube to slip through it.

Humans↗
PubMed1983

The cerebral function analysing monitor (CFAM). A new microprocessor-based device for the on-line analysis of the EEG and evoked potentials.

A description is given of a new microprocessor-based device for EEG analysis. The Cerebral Function Analysing Monitor (CFAM) analyses the EEG amplitude and frequency distribution. It produces a detailed plot of amplitude trends and separate traces of the percentage activity in each of the classical EEG frequency bands. Its clinical application was studied in five patients anaesthetized with thiopentone, and nitrous oxide and halothane in oxygen. During maintenance of anaesthesia, there was a gradual decrease in EEG amplitude and shift towards lower frequency EEG activity. Discontinuation of nitrous oxide resulted in a marked increase in EEG amplitude and an increase in alpha and beta band activity. Discontinuation of halothane resulted in smaller alterations in the CFAM trace. This device provides easily interpreted processed EEG data and merits further investigation.

Adult↗