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Biomedical subjects

M Franchi

Publications and source records attributed to M Franchi.

At least 127 records · Page 7Linked to original sources
PubMed1989

Ultrastructural changes of collagen and elastin in human gingiva during orthodontic tooth movement.

After 15 days of mesializing or distalizing orthodontic treatment, 10 permanent premolars of young patients were extracted with the interdental gingiva. The connective tissues of the compressed or stretched interdental papillae were compared to that of untreated samples by light and transmission electron microscope. Large collagen fibres bundles represented by fibrils with a banding pattern of 64 nm and a mean diameter of 75 nm were observed in compressed interdental gingiva. Several elastic fibres with a mean diameter of 950 nm were also present. In some central areas of compressed gingiva collagen fibrils longitudinally split into widely spaced microfibrils were often observed in proximity to the elastic fibres. In stretched and untreated interdental papillae the collagen fibrils presented a mean diameter of 66 nm and 57 nm respectively. In both groups, few elastic fibres ranging in diameter 600 nm were seen. The increased size of the gingival collagen fibrils undergoing pressure and tension is indicative of remodelling of the fibrous collagen system. The fair increase in number and size of elastic fibres in compressed gingiva suggests that the elastic fibre system takes over the place whenever a collapse of the collagenous framework occurs.

Child↗
PubMed1989

Complications of pelvic lymphadenectomy in patients with endometrial adenocarcinoma.

The complications of surgical treatment in 193 cases of endometrial adenocarcinoma, subdivided into two groups, were analyzed: 58 without lymphadenectomy and 135 with systematic pelvic lymphadenectomy before total abdominal hysterectomy and bilateral salpingo-oophorectomy with vaginal cuff. The only significant differences concern the number of patients requiring transfusions and the length of the postoperative stay. It is suggested that lymphadenectomy should always be performed when an abdominal approach is chosen.

Adenocarcinoma↗
PubMed1989

[Effect of laser light on polymerization of composite materials].

The purpose of this study is to verify the advantages of light Laser Argon Technique on composite resin polymerization. These results have been compared to the normal halogen light technique, used in daily practice the only advantage of Laser Argon Technique is the faster polymerization, compared to the normally employed technique, due to the brightness and monocromaticy of the laser bean.

Composite Resins↗
PubMed1989

Dedifferentiating endometrial adenocarcinoma. Report of a case.

A case of well differentiated endometrial adenocarcinoma in a 70 year-old patient is reported, which evolved to undifferentiated small cell after being treated with chemotherapy for six months. The possible mechanisms of dedifferentiation are briefly discussed.

Adenocarcinoma↗
PubMed1988

Effects of pulsed extremely-low-frequency magnetic fields on skin wounds in the rat.

Rats with skin-wounds surgically created on their backs were exposed immediately after surgery and every 12 h thereafter to pulsed, extremely-low-frequency magnetic fields. The shape of the pulse was a positive triangle (50 Hz, 8 mT peak). The rate of healing of skin wounds was evaluated macroscopically and by light and electron microscopy at 6, 12, 21, and 42 days after the operation. A significant increase in the rate of wound contraction was found in rats treated with magnetic fields. Forty-two days after surgery all treated animals show fully closed wounds, while control rats at the same time intervals still lacked a final 6% of the wound surface to be covered. Treated rats showed earlier cellular organization, collagen formation and maturation, and a very early appearance of newly formed vascular network.

Animals↗
PubMed1988

Glutathione S-transferase in humans: development and tissue distribution.

Glutathione S-transferase (GST) was investigated with benzo(a)pyrene-4,5-oxide (BPO) as substrate in tissue specimens from 26 fetal and 27 adult livers and 27 placentas. The average (+/- SEM) of GST activity in the cytosol was 1.80 +/- 0.18 (fetal liver), 3.05 +/- 0.30 (adult liver) and 1.18 +/- 0.07 (placenta) nmol/min/mg. GST was also investigated in human fetal and adult lungs, kidneys and gut. In these tissues the average (+/- SEM) GST activity ranged between 0.71 +/- 0.12 (adult intestine) and 2.11 +/- 0.18 (fetal lungs) nmol/min/mg. Whereas in the fetal liver the conjugation of BPO was catalyzed at a rate of about two-thirds of the adult rate, similar or higher GST activities were found in the fetal non-hepatic tissues as compared to the adult organs. No correlation was found between the activity of the GST in fetal liver and placenta and the gestational age (11-25 weeks). GST develops before the 11th week of gestation and it does not undergo changes during the mid-gestation. No correlation was found between GST activity in adult liver and age (32-70 years).

Adult↗
PubMed1988

Sulfotransferase in humans: development and tissue distribution.

Sulfotransferase with 2-naphthol as substrate was investigated in the cytosolic fraction of human fetal liver, lungs, kidneys, adrenal glands, intestine and placenta and also in liver, lungs, kidneys, intestinal and urinary bladder mucosa from human adult subjects. All tissue specimens assayed catalyzed the sulfation of 2-naphthol at a significant rate. The activity (expressed as pmole per minute per milligram protein; mean +/- SD) was 211 +/- 197 (n = 46) fetal liver; 22 +/- 12 (n = 29) placenta; 625 +/- 205 (n = 42) human adult liver. In fetal kidneys (576 +/- 177; n = 6) and gut (558 +/- 293; n = 6) the activity was twice as high as in liver. In the lungs (273 +/- 125; n = 6) and in the adrenals (174 +/- 119; n = 19) the sulfotransferase activity was comparable with the hepatic one. In human adult extrahepatic tissues the highest activity was found in the intestinal mucosa (153 +/- 49; n = 4) and the lowest one in the urinary bladder mucosa (16 +/- 4; n = 4). This paper shows that the sulfotransferase has a wide distribution in the human fetus and the distribution pattern of this enzyme is different in the human fetus and adult subject.

Adult↗
PubMed1988

Tissue distribution of drug-metabolizing enzymes in humans.

1. The activities of the ethoxycoumarin O-deethylase (ECOD), epoxide hydrolase (EH), UDP-glucuronyl transferase (GT), glutathione S-transferase (GST), acetyl transferase (AT) and sulphotransferase (ST) were measured in 6 liver, 8 lung, 8 kidney, 8 intestinal mucosa and 22 urinary bladder mucosa specimens from human subjects. EH and GT were studied with styrene oxide and 1-naphthol, respectively, as substrates, GST, AT and ST were studied with benzo(a)pyrene-4,5-oxide, p-aminobenzoic acid and 2-naphthol, respectively. 2. The enzyme activities were detectable at significant rates in liver, lungs, kidneys and gut. In urinary bladder, EH, GT, GST and ST only were detectable. The liver catalyzed the various reactions at higher rates than did other tissues. 3. Of the extrahepatic tissues, the intestinal mucosa contained the highest activities of AT (50% of liver) and ST (30% of liver), whereas kidneys contained the highest activity of GT (50% of liver) and GST (80% of liver). GST was the enzyme with the widest tissue distribution.

7-Alkoxycoumarin O-Dealkylase↗
PubMed1988

Sclerosing stromal tumour of the ovary. Ultrastructural study.

Two typical cases of sclerosing stromal tumours of the ovary are studied ultrastructurally, and the findings are correlated with the clinical data. One of the cases, with predominantly fibroblastic morphology, was asymptomatic. The second case, rich in cells with steroid-secreting features, had polymenorrhoea disappearing after removal of the tumour. The Authors suggest that clinical symptoms of sclerosing stromal tumour of the ovary depend from the degree of differentiation reached by the tumour cells.

Adult↗