Biomedical subjects
M Fowler
Publications and source records attributed to M Fowler.
Ultrasound of polyorchidism: case report and literature review.
We report a case of polyorchidism that was suggested preoperatively by scrotal sonography. A review of the literature on this rare anomaly discloses a previously underemphasized association with malignancy.
Holocord astrocytoma: a two-staged operative approach.
Biopsy or subtotal resection followed by radiation for intramedullary astrocytomas of the spinal cord offer palliation but not cure. A treatment modality using an ultrasonic suction device has revolutionized the treatment of these tumors and has been extended to include the treatment of intramedullary tumors involving the entire length of the spinal cord (holocord tumors) with evident success. An alternative to this technique, a two-staged microsurgical approach, allows complete excision of the tumor and thus offers a chance for cure. Two patients have been treated in this manner, and more than 3 years after the operations, both patients were still improving neurologically without any evidence of tumor recurrence.
Doppler echocardiographic indices of diastolic function as markers of acute cardiac rejection.
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Classical limit of sine-Gordon thermodynamics using the Bethe ansatz.
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Surgical treatment of laryngeal ossification in a tiger.
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Management of a schwannoma in the larynx of a lion.
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Soft modes in the one-dimensional Heisenberg antiferromagnet near saturation.
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Classical limit of Bethe-Ansatz thermodynamics for the sine-Gordon system.
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Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.
We used radioligand binding techniques and measurement of beta-agonist-mediated positive inotropic responses in isolated cardiac tissue to examine beta-adrenergic-receptor subpopulations in nonfailing and failing human left and right ventricular myocardium. In tissue derived from 48 human hearts the receptor subtypes identified in nonfailing ventricle by radioligand binding were beta 1 (77%) and beta 2 (23%), with no evidence of an "atypical" beta-adrenergic receptor. In failing left ventricle the beta 1:beta 2 ratio was markedly different, i.e., 60:38. This decrease in the beta 1 proportion and increase in the beta 2 proportion in the failing ventricles were due to a 62%, "selective" down-regulation of the beta 1 subpopulation, with little or no change in beta 2 receptors. In muscle bath experiments in isolated trabeculae derived from nonfailing and failing right ventricles, both beta 1- and beta 2-adrenergic receptors were coupled to a positive inotropic response. In nonfailing myocardium, beta 1 responses predominated, as the selective beta 1 agonist denopamine produced a response that was 66% of the total contractile response of isoproterenol. In heart failure the beta 1 component was markedly decreased, while the beta 2 component was not significantly diminished. Moreover, in heart failure the beta 2 component increased in prominence, as the contractile response to the selective beta 2 agonist zinterol increased from a minority (39%) to a majority (60%) of the total response generated by isoproterenol. We conclude that failing human ventricular myocardium contains a relatively high proportion of beta 2 receptors, due to selective down-regulation of beta 1 receptors. As a result, in the failing human heart the beta 2-receptor subpopulation is a relatively important mediator of inotropic support in response to nonselective beta-agonist stimulation and is available for inotropic stimulation by selective beta 2 agonists.
Magnon-mass renormalization in (CH3)4NMnCl
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Finite temperature excitations of the quantum sine-Gordon-massive Thirring model: Variation of the soliton mass with coupling constant and temperature.
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Sonographic findings in leiomyoma of postorchiectomy scrotum.
Leiomyomas of the scrotum are unusual testicular masses and a case report reviewing the ultrasonographic findings of this entity comprises this report. The ultrasonographic characteristics of leiomyoma have not been reported previously. The purpose of this case report is to discuss the findings of ultrasound in evaluation of leiomyoma in the area of the scrotum.
Tenckhoff catheter obstruction resulting from invasion by Curvularia lunata in the absence of peritonitis.
A 60-year-old black woman on continuous ambulatory peritoneal dialysis (CAPD) presented with Tenckhoff catheter malfunction. She exhibited no signs or symptoms of acute peritonitis. Darkly pigmented plaques were adherent to the inner wall of the catheter and exchange tubing focally throughout its length. Similar material was adherent to the protein coagulum in the dialysis bag. The Tenckhoff catheter and tubing were removed, and hemodialysis was initiated. Cultures of the catheter and the dialysate protein coagulum grew the saprophytic soil fungus, Curvularia lunata. Histologic examination of the catheter and tubing demonstrated penetration of each by hyphae. Catheter removal alone was sufficient to eradicate the fungus since recurrence of colonization or peritonitis has not occurred following the resumption of CAPD. Peritonitis produced by opportunistic pathogens especially fungi is increasingly common. Although Curvularia species have been implicated in pulmonary and cerebral mycetomas, allergic bronchoalveolar disease, and keratitis, they have not been reported previously to cause peritonitis or catheter malfunction in CAPD patients. Fungal invasion of CAPD catheters can produce mechanical obstruction even in the absence of peritonitis. Such colonization does not preclude resumption of chronic peritoneal dialysis at a later date.
Lymphocytic-plasmacytic colitis in two cheetahs.
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Successful treatment of audycoptid mange in a black bear.
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People and dollars: the experience of one hospice.
The Hospice of the North Shore (HONS) provides home hospice care, using local hospitals when inpatient care is essential. The actual cost of 4,779 patient days of care delivered from May 1, 1980 through Dec 31, 1981 was $14.26 per patient day. The median length of service was 31.5 days, with a mean of 66.4 days. Care was provided to 22.3% of all those dying of cancer during 1981 within the service area of the HONS. It is estimated that each patient receiving hospice care avoids 11.05 days of traditional inpatient care, resulting in a saving of $3,167.06 during the index period of this study. If this saving were extrapolated to a national scope, it is conservatively predicted that approximately $266,000,000 could be saved annually. The experience of the HONS strongly supports further development of outpatient, home care hospice organizations.