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Biomedical subjects

M Fontaine

Publications and source records attributed to M Fontaine.

223 records · Page 13Linked to original sources
PubMedDate not supplied

[Improvement of blood filtrability with a purified extract of black currant anthocyanosides in cynomologus monkeys on a fat diet].

A fat diet has been administered for 3 months to Cynomologus monkeys treated with blackcurrant anthocyanosides as compared with others receiving no treatment. Blood filtrability of animals given a fat diet alone was significantly lowered (20.8%; p less than 0.01) as compared with that of animals receiving a standard diet. Blood filtrability of animals receiving a fat diet plus blackcurrant anthocyanosides was not significantly different from that of animals given a standard diet. Emphasis is laid on a new approach to the action of this type of product on blood vessel contents as compared with the known action on the container.

Animals↗
PubMedDate not supplied

[Substances contained in the coelomic fluid of Lumbricus terristris having functions in common with those of some human complement components].

In the present work, it was demonstrated for the first time that the coelomic fluid of Lumbricus terrestris contained a substance recognized by human classical convertase. This substance permitted an immune, complement-dependent agglutination response of sheep erythrocytes carrying C3-convertase (EAC142). In addition, substances secreted by coelomic leukocytes possessed an inhibitory activity against human complement: the component C3 was cleaved into a C3b fragment. This result suggests the presence of a system the function of which is C3-convertase-like. We have thus shown that some complement functions, with their natural inhibitors, appear early in evolution. Certain of these functions and structures might be preserved throughout evolution.

Animals↗
PubMedDate not supplied

Evidence that an autoantibody of IgG3 subclass against C3b discloses a C3 Nef activity in a pateint with partial lipodystrophy and glomerulonephritis.

Immunoglobulins of IgG3 subclass were purified from the serum of a patient with partial lipodystrophy and glomerulonephritis. The immunochemical data clearly showed that the immunoglobulins were directed against newly-formed determinants on C3 molecule when activation of complement occurred. This autoantibody property was related to the C3 nephritis factor activity present in the serum of the patient. Furthermore, this serum was unable to destroy cell bound C3b. This result suggested that this patient would presented a deficiency of C3b inactivation system.

Adult↗
PubMedDate not supplied

Selective deficiencies in complement component : a family with hereditary C2 deficiency.

We report herein a new case of C2 deficiency in a patient with systemic lupus. The subject and one of her brothers, who shows no clinical manifestations, are hymozygous C2 deficient. All other family members are heterozygous for the C2 deficiency. Gene for C2 deficiency (C2d) was shown to be inherited with HLA-A9, B7/Bfs and HLA-A10, B27/Bfs haplotypes. This association has not previously been described.

Adolescent↗