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Biomedical subjects

M Fodor

Publications and source records attributed to M Fodor.

At least 73 records · Page 4Linked to original sources
PubMed1989

[Nausea and vomiting induced by chemotherapy: bases to a rational treatment].

Nausea and vomiting are a serious side effect of chemotherapy, frequently leading to failure of treatment compliance. Chemotherapeutic agents act preferentially on the chemo-receptor trigger zone located at the floor of the 4th ventricle. Vomiting may develop at initiation of therapy or several days later. Phenotiazine derivatives, butyrophenones or methochlopramide are particularly useful by their anti-dopaminergic effects. Canabinoids or steroids may be also useful. Combinations of drugs are frequently required.

Antiemetics↗
PubMed1988

Localization of corticotropin-releasing factor, somatostatin, and vasoactive intestinal polypeptide in the parabrachial nuclei of the human brain.

The immunocytochemical localizations of corticotropin-releasing factor (CRF), somatostatin (SRIF), and vasoactive intestinal polypeptide (VIP) were studied in the human parabrachial nuclei (PBN) using the avidin-biotin complex (ABC) technique. The brains were obtained from seven adult male human subjects of 38-74 years. In three cases, the brains were fixed within 2 hr, in four cases within 5 hr, postmortem. All of these peptides were detected in fibers through the orocaudal extent of the lateral PBN, whereas the medial nucleus contained only CRF immunoreactive fibers. Immunoreactive fibers were distributed unevenly within the lateral nucleus with the highest density in the dorsal and much fewer in the ventral part of the lateral subdivision. The highest to lowest density of immunostained processes were detected using CRF, SRIF, and VIP antisera, respectively. Since NPB is known as an important relay nucleus for the central autonomic pathway, the presence of the above noted neuropeptides in nerve fibers in this area may suggest a neurotransmitter or neuromodulatory role of CRF, somatostatin, and VIP in certain autonomic nervous mechanism of the human brain.

Adult↗
PubMed1988

Bilateral renal tumours with reference to the reoperation of a solitary kidney resected for tumour.

A case of bilateral renal tumour is reviewed, where the disease was detected by sonography performed for screening. On one side, nephrectomy, while on the other, partial resection of the kidney were performed in two sessions. Due to occlusion and a resultant renal fistula produced by scar tissue following the second operation as well as to progressive azotaemia, reoperation of the solitary kidney resected for tumour became necessary. As a result of the failure of both cytostatic and radiotherapy, the authors believe that, in similar cases, every surgical method possible should be used for prolonging the patient's life. In the available literature no reference has been found on the reoperation of solitary kidney resected for malignant tumour.

Adenocarcinoma↗
PubMed1981

Effect of tracheal suction on oxygenation, circulation, and lung mechanics in newborn infants.

Transcutaneous PO2, heart rate, and aortic blood pressure were measured i 10 mechanically-ventilated newborn infants to assess the degree and course of hypoxaemia, and to monitor the cardiovascular and respiratory changes during tracheal toilet. Five infants weighed less than 1250 (mean 994), g and 5 infants weighed greater than 1750 (mean 2216) g. During tracheal suction the TcPO2 fell from 68 +/- 27 (mean +/- SD) to 43 +/- 23 mmHg, and the heart rate from 144 +/- 8 to 123 +/- 25 beats/minute, but the blood pressure increased from 44 to +/- 24 to 49 +/- 24 mmHg. Hypoxaemia (TcPO2 less than 50 mmHg) occurred in 7 of 8 initially well-oxygenated infants when suctioned. The decrease in TcPO2 was similar for both groups of infants. It was greater in infants with controlled ventilation and an F1O2 greater than or equal to 0.8 than in infants with intermittent mandatory ventilation and an F1O2 less than 0.8. The TcPO2 fall correlated well with the TcPO2 during the control period but not during the time that the infants were disconnected from the respirator. A critical re-evaluation of routine tracheal toilet is needed.

Blood Pressure↗