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Biomedical subjects

M Flannery

Publications and source records attributed to M Flannery.

27 records · Page 2Linked to original sources
PubMedDate not supplied

Midgestational exposure of pregnant BALB/c mice to magnetic resonance imaging conditions.

The potential for producing reproductive toxicity or teratogenesis in mice by exposure to magnetic resonance imaging (MRI) conditions was evaluated by means of reproduction studies and the homeotic shift test. Embryos from pregnant BALB/c mice were exposed in vivo for 16 hours beginning on gestation day 8.75 to MRI conditions of modest field strength (static field, 0.35 tesla (T); pulsed gradients, 2.3 X 10(-4) T/cm for 2.5 to 10 msec; and radio frequency, 15 MHz at an average of 61.2 mW). Unexposed, sham-exposed (both MRI and X-ray) and X-irradiated (0.5 Gy) animals were the control groups. Neither placental resorptions nor stillbirths were increased by MRI. Fetal weight at birth and crown-rump length were proportional; however, crown-rump length was significantly less (p less than 0.001) in the MRI-exposed fetuses (respective mean values for MRI-exposed fetuses were 21.8 +/- 0.2 mm compared to 22.4 +/- 0.1 for sham-exposed fetuses). Both crown-rump length and fetal weight were significantly reduced after X-irradiation. The percentage of homeotic skeletal shifts was scored for each of eight anatomic sites. Only X-radiation produced significant increases in skeletal shifts. Prolonged midgestational exposure of mice to MRI conditions currently used for human clinical imaging, therefore, failed to reveal overt embryotoxicity (resorptions, stillbirths) or teratogenicity (homeotic shifts), consistent with the non-ionizing properties of MR. However, the slight but significant reduction in fetal crown-rump length after prolonged exposure justifies further study of higher MRI energy levels and consideration of other endpoints for establishing with greater confidence the safety of MRI during pregnancy.

Animals↗
PubMedDate not supplied

Nursing care by telephone: describing practice in an ambulatory oncology center.

Ambulatory oncology nursing care focuses on providing patients and families with the knowledge and resources needed to manage the symptoms of disease and the side effects of treatment. Nurses practicing in ambulatory care settings have limited face-to-face interaction with patients and families. As a result, telephone contact is used to give information, provide encouragement, and assess the patient's condition. To develop and test methods of delivering care to oncology patients by telephone, current practices must be documented. This study describes the use of the telephone in ambulatory oncology nursing in one patient care setting. Over a six-month period, nurses reported on 1,844 patient calls. Data collected on these telephone calls included: duration, initiator, purpose, nurse's assessment of urgency level, impact on the nursing care plan, and changes made in the use of healthcare services. The Outcome Standards for Cancer Nursing Practice of The American Nurses' Association and the Oncology Nursing Society most frequently addressed during the calls were information, comfort, and coping. Nurses in this setting functioned independently, handling 91% of the calls they received and using consultation for 52% of the calls.

Adaptation, Psychological↗
PubMedDate not supplied

Developing clinical program guidelines for subacute care.

Providers of subacute care are now faced with the reality of demonstrating their claims that they offer cost-effective programs. Developing internal standards or guidelines from an organizational and clinical perspective can help to assure and validate quality service delivery.

Cost-Benefit Analysis↗