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Biomedical subjects

M Fisher

Publications and source records attributed to M Fisher.

At least 559 records · Page 31Linked to original sources
PubMed1979

Teaching "street law" to the criminally insane.

A course in "Street Law" was taught to forensic patients by law students, following a format used by Georgetown University Law Center. Although the course has been taught to high school students and inmates of correctional facilities, this was the first time it has been extended to mental patients found not guilty of crimes by reason of insanity. An outstanding feature of the course was marked enthusiasm shown by patients who, through long institutionalization, had become apathetic, indifferent, and despairing. Their readiness and ability to learn brought to mind a couple of old sayings often heard around mental hospitals, "I may be crazy but I'm not stupid," and "Sometimes you can't tell the patients from the staff." The staff of at least one ward has picked up "teaching and learning to use as a central theme in treatment of patients, not abandoning traditional methods, but shifting the emphasis from therapy to teaching as a way of getting the patient's interest in his own rehabilitation. Judges, reviewing cases for release, have looked quizzical when the patients' active participation in a "law course" has been used as evidence of satisfactory progress.

Criminal Law↗
PubMed1978

Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature.

Two cases of hereditary hemorrhagic telangiectasia (HHT) with neurological involvement are presented. One patient had multiple vascular malformations including telangiectasias of the brain, medulla, and spinal cord and a berry aneurysm of the internal carotid artery; she also had a large cerebellar abscess, presumably reflecting the presence of a pulmonary arteriovenous fistula. The second patient had an idiopathic subarachnoid hemorrhage. In more than 200 reported patients with HHT involving the nervous system, 61% had lesions seondary to a pulmonary arteriovenous fistula (cerebral hypoxemia, paradoxical and septic emboli, and brain abscess). The findings emphasize the need for early surgical correction of such fistulas. In 36% of the patients with neurological involvement and HHT, vascular malformations of the brain and spinal cord were documented, and in 3%, portal-systemic encephalopathy was noted. Multiple lesions were frequent. HHT should be considered a generalized vascular dysplasia (universal or systemic angiomatosis), and not simply a benign mucocutaneous disease.

Aged↗
PubMed1978

Background and sexual experience of Israeli medical students.

It is now general professional consensus that to develop a good human sexuality curriculum it is mandatory to first study the future target population, Such a study was done on a national basis at the four medical schools in Israel, concentrating on the senior students. The data on background, sexual experience, knowledge, and attitudes were analyzed and compared to findings of similar studies in other countries. This article reviews the results on background and sexual experience, also trying to analyze logical hypotheses of possible links between variables. Most Israeli senior medical students are unmarried Jewish Ashkenasi males, with a rather small proportion of females, Sephardic-originated Jews, Moslems, and Christians. Their sex education during childhood originated mostly from peers and literature, but was almost completely lacking at school. Masturbation started early, being more frequent for males. The majority of both sexes had dated, had gone steady, and had had sexual intercourse frequently with at least two partners. Only 5.4% of males had never experienced coitus. Intercourse with prostitutes was infrequent. The students' background has direct influence on their early sexual knowledge and experience. This in turn influences self-ratings on sexual matters. This is further correlated with sexual behavior.

Adolescent↗
PubMed1978

Althesin reactions.

Explore the source record for details and available documents.

Alfaxalone Alfadolone Mixture↗
PubMed1978

Significance of blood cadmium concentrations in patients with renal disorders or essential hypertension and the normal population.

Cadmium concentrations in whole blood have been determined in normal control subjects, in patients with untreated essential hypertension or with treated essential hypertension, and in those with acute or chronic renal disorders. High cadmium concentrations were not found in the patients with untreated essential hypertension. Most tobacco smokers were found to have high blood cadmium concentrations. When the mean cadmium concentrations from each group of patients were compared with those of the control subjects no significant differences were found. When the four groups were divided into smokers and non-smokers, however, a significantly higher mean value was found for the non-smoking renal patients in comparison with the non-smoking normal subjects. The marked increases in blood cadmium concentration in the patients with renal disorders may be attributed to impaired excretion.

Acute Disease↗
PubMed1978

Heinz body formation in calf erythrocytes.

Heinz body formation was induced in calf erythrocytes by a daily dose of 8 mg phenylhydrazine/kg body weight. Body weights and feed intakes were not affected, the glutathione content of erythrocytes was reduced, but the hemolysis rate of erythrocytes was not changed. Morphological changes in erythrocytes were shown by light and high resolution scanning microscopy. The appearance of Heinz bodies may have value as an indicator of oxidative stress under conditions such as copper toxicity or deficiency of selenium-vitamin E.

Animals↗
PubMed1978

Hyperglucagonemia in cirrhosis: altered secretion and sensitivity to glucagon.

Plasma glucagon concentration was elevated 2- to 6-fold in cirrhotic patients with spontaneous portal systemic shunting or surgically induced portacaval anastomosis but was comparable to controls in cirrhotics without portal-systemic shunting. The metabolic clearance rate of glucagon (mol wt 3500) was normal in all of the cirrhotic groups, but the estimated basal systemic delivery rate of glucagon was increased 2- to 6-fold in the hyperglucagonemic patients. The blood glucose response to infusion of glucagon (3 ng per kg per min) was reduced in the cirrhotics with portal-systemic shunting or portacaval anastomosis, and correlated inversely with the delivery rate of endogenous glucagon. Administration of ammonium chloride (3 g) failed to elevate plasma glucagon concentration. It is concluded that hyperglucagonemia in cirrhosis is a consequence of hypersecretion rather than decreased hormonal catabolism. A negative feedback signal may exist between hepatic sensitivity to glucagon and the secretion of this hormone.

Adult↗
PubMed1977

Studies of the receptor for phage A25 in group A streptococci: the role of peptidoglycan in reversible adsorption.

Irreversible adsorption of a virulent phage, phage A25, to heat-killed streptococci, groups A, G, and A variant, has been achieved. Adsorption reflected the observed host range for phage A25 in that heat-killed group B cells were not able to inactivate the phage. Broken cells, cell walls, and peptidoglycan prepared from a group A strain K56 failed to adsorb the phage irreversibly, but retained the potential to carry out reversible adsorption. Experimental data including electron microscopy have demonstrated the specificity of reversible adsorption and have identified the peptidoglycan as a necessary cellular component of the receptor. The sensitivity of whole cells and purified peptidoglycan to muralytic enzymes suggests that the cell wall and peptidoglycan must be intact for optimal adsorption. In general the results are explained by postulating that adsorption of A25 phage particles to group A cells occurs by a two-step process; the first step involves recognition and reversible binding of the phage tail to the cell wall peptidoglycan, the second step is an irreversible reaction catalyzed by a yet unidentified cellular component which is destroyed when cells are ruptured.

Adsorption↗
PubMed1977

Syphilitic meningomyelitis. A case report.

A 58-year-old man was admitted with a progressive, subacute asymmetrical paraparesis. The patient denied a previous syphilitic infection, but spinal fluid examination disclosed a lymphocytic pleocytosis, hypoglycorrhachia, and a positive serologic test for syphills. Clinical improvement resulted from a 14-day course of penicillin. Syphilitic involvement of the nervous system appears to be increasing in the United States and should be included in the differential diagnosis of progressive paraparesis.

Humans↗
PubMed1977

Blood volume replacement in acute anaphylactic cardiovascular collapse related to anaesthesia.

In seven patients who suffered anaphylactic cardiovascular collapse during anaesthesia the degree of haemoconcentration was used to assess changes in blood volume. The patients who were resuscitated with electrolyte solutions, or electrolyte solutions with a small volume of colloid, showed haemoconcentration suggesting plasma loss of 20.2-37%. Patients who were resuscitated initially with colloid solutions showed minimal haemoconcentration. In anaphylactic cardiovascular collapse, the reduction of blood volume is a result of loss of plasma and colloid solutions should be used to replace the volume deficit.

Anaphylaxis↗
PubMed1977

Effects of hydrochlorides of amino acids in test meals on gastric emptying.

Four subjects were given test meals containing various concentrations of hydrochlorides of glycine, alanine, arginine, phenylalanine and tryptophan. The gastric contents were recovered after 20 min. The volume of the original meal recovered was assessed from the amount of marker substance aspirated. It was found that the slowing of gastric emptying of amino acid hydrochlorides was consistent with their action as weak acids. However, tryptophan and phenylalanine were slightly more effective than was predicted on the basis of their actions as acids.

Amino Acids↗
PubMed1977

Postoperative intravenous therapy.

The physiology of the post-operative surgical patient is discussed. The reasons for the controversy between high and low volumes of fluid post-operatively are examined and a regime of relative fluid restriction is recommended. The requirements of the post-operative patient are discussed and a regime for post-operative therapy proposed.

Animals↗
PubMed1977

[Possibilities of drug-induced prevention of thrombosis with special reference to pre-, per- and postoperative time of treatment].

According to the postoperative prophylaxis of thromboembolia a review of actual publications is given. The therapeutical problems of Coumarin, Dextran, Acetylsalicylic acid and low dosis Heparin were discussed. A final answer to the various questions can not be given. Concerning the prophylaxis low dosis Heparin seems to become the anticoagulant of choice.

Aspirin↗