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Biomedical subjects

M Fink

Publications and source records attributed to M Fink.

At least 163 records · Page 9Linked to original sources
PubMed1994

Continuation ECT: relapse prevention in affective disorders.

Relapse rates after the acute treatment of affective disorders with drugs or electroconvulsive therapy (ECT) are high (often 50-95%), despite preventive pharmacotherapy. In practice, some patients receive continuation and maintenance ECT after successful treatment of the index episode with ECT. We reviewed the charts of patients with affective illnesses who received continuation ECT (C-ECT) in our inpatient service from 1985 to 1991. In 33 courses of C-ECT, mean intertreatment interval was 10.1 days and the average duration of treatment was 10 weeks. One-year follow-up was available for 21 patients. Seven (33%) patients relapsed and needed re-admission within 1 year. The relapse rate for the patients with delusional depression was 42%, lower than the 95% reported for patients with delusional depression maintained on continuation pharmacotherapy before the C-ECT program started in our facility. No single factor examined was a significant predictor of relapse except C-ECT, which exhibited a sustained prophylactic effect for the year after the index episode.

Adult↗
PubMed1994

[Innsbruck results of bone marrow transplantation in treatment of hematologic neoplasms and solid tumors].

87 patients underwent bone marrow transplantation (BMT) in Innsbruck between 1983 and 1992. 81 patients were suffering from hematologic malignancies and severe aplastic anemia and six patients had advanced solid tumours/sarcoma. 56% of the patients undergoing HLA-identical sibling BMT were in an advanced or refractory stage of disease at the time of BMT. 19 patients underwent autologous BMT and 5 patients received a graft from an HLA-matched unrelated donor. Patients were treated with standard conditioning regimens according to the underlying disease. Cyclosporine A (CsA) was given prophylactically against graft-versus-host disease (GVHD) either alone or in combination with methotrexate. Probability of survival for patients transplanted in the first chronic phase of chronic myelogenous leukemia (CML) was 85%, whereas the disease free survival (DFS) for patients transplanted in accelerated phase or blast crisis was only 40%. DFS for acute myelogenous leukemia (AML) in first complete remission and acute lymphoblastic leukemia (ALL) standard-risk (i.e., first or second complete remission) was 71% and 60%, respectively. All patients transplanted for non-Hodgkin's lymphoma (NHL) or Hodgkin's disease had refractory or advanced disease. Probability of survival for lymphoma patients was 60%. Acute GVHD > grade II developed in 35% of patients undergoing HLA-identical sibling BMT (46% in the high-risk group vs. 21% in the standard-risk group). Main causes of death in the high-risk group were relapse (31%), severe bacterial or fungal infections (17%), interstitial pneumonia (11%) and acute GVHD (6%).

Adolescent↗
PubMed1993

[History of electroconvulsive therapy in the United States in the last decades].

Despite its acknowledged efficacy and safety in the treatment of patients with severe affective and psychotic illnesses, as well as extensive efforts at professional and public education, electroconvulsive therapy is a neglected treatment, its use in the U.S. being mainly restricted to academic and private hospitals. Widespread use between 1935 and 1960, a rapid decline following the introduction of psychoactive drugs, and a slow resurgence in clinical interest since 1975 characterizes its history. The use of ECT has been encouraged by repeated favorable evaluations and by new procedures which improve both its efficacy and its safety. The experience in the United States provides a lesson for other nations where its use is inhibited.

Depressive Disorder↗
PubMed1992

Case report: liver adenomatosis presenting as multiple calcified masses.

Liver adenomatosis is a rare condition with only 14 cases reported. It is considered to be a distinct entity from liver adenoma. This is the first case in which calcification has been described. The differential diagnosis of multiple calcified lesions in the liver is discussed, and other features of liver adenomatosis.

Adenoma↗