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Biomedical subjects

M Figueroa

Publications and source records attributed to M Figueroa.

At least 55 records · Page 3Linked to original sources
PubMed1993

Clinical determinants of dementia related to stroke.

Among 251 patients examined 3 months after the onset of acute ischemic stroke, we diagnosed dementia in 66 (26.3%) by using modified DSM-III-R criteria based on neuropsychological, neurological, functional, and psychiatric examinations. We used a logistic regression model to derive odds ratios (ORs) for clinical factors independently related to dementia in this cross-sectional sample. Dementia was significantly associated with age, education, and race. A history of prior stroke (OR = 2.7) and diabetes mellitus (OR = 2.6) was also independently related to dementia, but hypertension and cardiac disease were not. Stroke features associated with dementia included lacunar infarction compared with all other subtypes combined (OR = 2.7) and hemispheric laterality in relation to brainstem or cerebellar location. There was a predominance of dementia in patients with left-sided lesions (OR = 4.7), an effect not explained by aphasia. Dementia was especially common with infarctions in the left posterior cerebral and anterior cerebral artery territories. A major dominant hemispheral syndrome (reflecting size and laterality) was also independently associated with dementia (OR = 3.9). We suggest that dementia after ischemic stroke is a result of multiple independent factors, including both small subcortical and large cortical infarcts especially involving the left medial frontal and temporal regions, with additional contributions by demographic and vascular risk factors.

Age Factors↗
PubMed1990

[Clinical use of chlorhexidine].

There is a wide variety of literature regarding chlorhexidine, so we have tried to put together the most recent studies in order to apply them to our clinical reality. Chlorhexidine is an excellent alternative which should be considered as the best chemical collaborator available in the market. In order to obtain the best therapeutic effects, chlorhexidine should always be used within a plaque control program administered by a professional. It's the best way to get the best advantages offered by this medicine.

Chlorhexidine↗
PubMed1986

Localization of alkaline phosphatase activity at microbody membranes of Neurospora crassa and Aspergillus nidulans.

Hyphal cells of Neurospora crassa and Aspergillus nidulans, grown in Sabouraud glucose broth or in a defined medium with xanthine or its catabolites as the nitrogen source, contained single membrane-bound organelles cytochemically identified as microbodies. Modified Gomori procedures at the ultrastructural level revealed putative alkaline phosphatase activity sites in thin sections of cells of both species of fungi. Microbody membranes displayed electron opaque deposits (lead phosphate) which were absent in control preparations either lacking the substrate (beta-glycerophosphate) or the lead capture ion. Inhibition of this enzymic activity was achieved in parallel incubations fortified with the inhibitor levamisole. Cells grown in media containing limiting levels of inorganic phosphate revealed additional alkaline phosphatase activity at and along the nuclear membrane and endoplasmic cisternae. Hexagonal inclusions found in the cytoplasm of N. crassa (but not A. nidulans) and believed to arise from microbody precursors were without demonstrable cytochemical staining for microbody marker oxidases.

Alkaline Phosphatase↗
PubMed1984

Post-trial injection of atropine into the caudate nucleus interferes with long-term but not with short-term retention of passive avoidance.

One-trial passive avoidance training was given to Wistar rats and retention of the task was measured 30 min and 24 h later. Atropine (60 micrograms) was injected into the anterior caudate nucleus 2 min after training. Excellent retention was evident 30 min after training, whereas a significant deficit in memory was found when retention was tested 24 h after training. These results suggest that blockade of cholinergic activity of the caudate nucleus induced shortly after training interferes with the consolidation of long-term memory but not with short-term memory processes.

Animals↗
PubMed1981

Time-dependent retention deficits induced by post-training injections of atropine into the caudate nucleus.

Rats were trained on a one-trial passive avoidance task, and retention of the task measured 24 hr later. Atropine was injected bilaterally into the anterior caudate nuclei (ACN) of rats from independent groups at one of several intervals after training. Application of atropine 2 min after training produced a lack of retention of passive avoidance. An intermediate degree of impairment was seen when the treatment was given 3 min 45 sec after the learning experience, and interference with retention was still noted when an interval of 7 min 30 sec was studied. In contrast, no deficits were observed in groups of animals injected with atropine 15 or 30 min after training. Rats injected with atropine into the parietal cortex 2 min after training showed only a minimal reduction of retention, and a group injected with saline solution into the ACN performed as well as non-treated animals. These results suggest that there is a time-dependent process that mediates the retention of passive avoidance, and that this process requires the activation of cholinergic synapses within the anterior caudate nucleus.

Animals↗
PubMed1978

Identification of a herpesvirus isolated from cytomegalovirus-transformed human cells.

Human cells transformed by cytomegalovirus and transplanted to athymic nude mice yielded a cytopathic virus, Hershey Medical Center virus, following prolonged in vitro passage of the tumor cells. The virus is a double-enveloped herpesvirus, is sensitive to ether, and is inhibited by iododeoxyuridine. No significant antigenic relationship to herpes simplex virus was detected using herpes simplex virus-immune sera in neutralization and immunofluorescence tests, but indirect immunofluorescence tests revealed cytomegalovirus-related antigenicity. Further immunological tests revealed that Hershey Medical Center virus is antigenically indistinguishable from infectious bovine rhinotracheitis virus. Thus, it appears that Hershey Medical Center virus is infectious bovine rhinotracheitis virus, which presumably appeared in the cell culture as a contaminant from fetal calf serum.

Animals↗
PubMed1977

[Angiographic study of the vascularization of primary malignant tumors of the liver: histological correlation].

During the last seven years 118 patients with histologic diagnosis of malign tumor in the liver were examinated by selective angiography, amongst other diagnostic recourses: 14 patients had primitive tumors: 12 hepatoma, 1 cholangiocarcinoma and 1 hepatocholangiocarcinoma. In 12 patients resection was contraindicated preoperative by the angiographic demonstration of the extension of the tumor to both lobes. In 1 patient with cholangiocarcinoma, the tumor was resected with an outlive of 4 years. In 1 patient with hepatoma very vascular a hard league of the right hepatic artery was done. Two months later angiography demonstrated a rich revascularisation of the tumor with development of the colateral circulation. In our experience the hiper or hipovascularization is related with the degree of fibrosis which accompanies the tumor and no so much with the histologic type, the degrees of differentiation or the existence of intratumoral necrosis. Emphasis is been done to show the diagnostical difficulties of hipovascularized tumors and the importance of angiography in the preoperative evaluation of hepatic tumors.

Adult↗