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Biomedical subjects

M Ferrari

Publications and source records attributed to M Ferrari.

At least 667 records · Page 37Linked to original sources

Emotional concomitants of childhood epilepsy.

On the basis of the distinguishing features of unpredictability, overt manifestation of symptom, and loss of control in epilepsy, a number of hypotheses about possible emotional concomitants of childhood epilepsy are offered. Comparing fifteen epileptic children with groups of diabetic and healthy children, matched for chronological age, sex, mental age, socioeconomic status, and family variables, the following findings emerged. Epileptic children are more likely than their diabetic or healthy peers to attribute control over even successful events in their lives to external sources. The perception of control by powerful others or by unknown factors was especially pronounced with regard to social events. In addition, epileptic children as a group were found to have lower self-concepts (particularly with regard to their popularity) and to be more anxious than their peers. The clinical and research significance of the findings are discussed.

Child↗

Determination of the anaerobic threshold by a noninvasive field test in runners.

The relationship between running speed (RS) and heart rate (HR) was determined in 210 runners. On a 400-m track the athletes ran continuously from an initial velocity of 12-14 km/h to submaximal velocities varying according to the athlete's capability. The HRs were determined through ECG. In all athletes examined, a deflection from the expected linearity of the RS-HR relationship was observed at submaximal RS. The test-retest correlation for the velocities at which this deflection from linearity occurred (Vd) determined in 26 athletes was 0.99. The velocity at the anaerobic threshold (AT), established by means of blood lactate measurements, and Vd were coincident in 10 runners. The correlation between Vd and average running speed (mean RS) in competition was 0.93 in the 5,000 m (mean Vd = 19.13 +/- 1.08 km/h; mean RS = 20.25 +/- 1.15 km/h), 0.95 in the marathon (mean Vd = 18.85 +/- 1.15 km/h; mean RS = 17.40 +/- 1.14 km/h), and 0.99 in the 1-h race (mean Vd = 18.70 +/- 0.98 km/h; mean RS = 18.65 +/- 0.92 km/h), thus showing that AT is critical in determining the running pace in aerobic competitive events.

Adolescent↗

Vitamins and immunity: II. Influence of L-carnitine on the immune system.

Vitamin A affects the antibody responses and may affect phagocytic function and properdin levels. Pyridoxine deficiency impairs nucleic acid synthesis and depresses antibody formation, delayed hypersensitivity reactions and the ability of phagocytes to kill bacteria. Pantothenic acid deficiency impairs antibody formation. Vitamin C deficiency increases the incidence of infection, primary by a negative influence on reparative processes. Deficiencies of other vitamins either have not been sufficiently studied or have a variable effect. Moreover, even substances which for their biosynthesis require an adequate vitamin supplementation may exert immunomodulatory influences. With this respect the authors report their results on the influence of L-carnitine on the immune system. L-carnitine increases the proliferative responses of both murine and human lymphocyte following mitogenic stimulation and increase polymorphonuclear chemotaxis. Furthermore, L-carnitine, even at minimal concentrations, neutralizes the lipid induced immunosuppression.

Animals↗

[Colorimetric determination of urinary iron, chelated with deferoxamine B, using a single reagent].

A new colorimetric method for the determination of urinary iron chelated with desferrioxamine B is proposed. A single reagent (ferrozine plus thioglycolic acid 1%) is utilized. Analytical range reached about 25 mg of iron/l, while the detection limit was 0.2 p.p.m. The evaluation of imprecision and inaccuracy were within acceptable limits. Moreover, there is good correlation with the atomic absorption spectrophotometric technique. This test shows good reliability.

Colorimetry↗

Reversibility by L-carnitine of immunosuppression induced by an emulsion of soya bean oil, glycerol and egg lecithin.

Experimental and clinical data appear to indicate that Intralipid--an emulsion of soya bean oil, glycerol and egg lecithin--which is usually employed to improve caloric intake of parenteral nutrition regimens, may compromise human host defence mechanisms and therefore expose patients to an increased incidence of infectious diseases. Since from a biochemical point of view it has been suggested that a possible way whereby the somewhat poor reputation of Intralipid--attributable to the liver damage and the persistent lipaemia which attend its use--might be improved is to give supplementary carnitine which acts as a rate-limiting factor in the removal of the fat emulsion from blood, we hypothesized that the addition of carnitine to Intralipid could also result in a improvement of the immune responses both "in vitro" and "in vivo". Our results lend some support to the hypothesis in favour of a metabolic basis for some of the immunosuppressive properties of Intralipid and justify the inclusion of L-carnitine in parenteral nutrition regimens which, by abrogating some co-factor limitation, improves the immune responses of the host.

Carnitine↗

Rat brain monitoring by near-infrared spectroscopy: an assessment of possible clinical significance.

Near-infrared 700-950 absorbance of some chromophores has been measured in different biological tissues, in particular rat and rabbit brain, to assess value of this noninvasive technique for monitoring of the regional functional state. Experiments carried out under different induced circulatory conditions confirmed the possibility of obtaining information on local blood content and hemoglobin oxygenation level as well as an indication of redox state of cytochrome c oxidase, the enzymatic complex that catalyzes about 95% of cellular oxygen consumption. The near IR spectral data were correlated with the result of independent simultaneous measurements of circulatory function: blood pressure, local blood flow, and local blood volume.

Animals↗

Quantitative measurements of tissue blood flow by fast pulse heated thermistors.

Continuous measurements of local blood flow were performed by means of short pulse heated miniature thermistors. Results obtained in rat cerebral cortex or skeletal muscle show good stability of the recordings and the sensitivity of the system to phasic changes in local blood flow. Experiments on perfused rabbit kidney support the possibility of using this method for quantitative measurements.

Animals↗

Arthrogryposis-like signs in trisomy 18.

Two cases of newborn male infants afflicted with trisomy 18 and with signs of arthrogryposis multiplex congenita (AMC) are described. Anomalies occurring in most cases of trisomy 18 such as polyhydramnios, reduced foetal activity, and skeletal muscle hypoplasia decrease articular movements and, thus might cause AMC. Since AMC is rarely associated with trisomy 18, chromosomal aberration is not the only factor involved in these cases.

Arthrogryposis↗