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Biomedical subjects

M Fernando

Publications and source records attributed to M Fernando.

18 recordsLinked to original sources
PubMed2000

CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor.

CEA-related cell adhesion molecule 1 (CEACAM1) exhibits angiogenic properties in in vitro and in vivo angiogenesis assays. CEACAM1 purified from granulocytes and endothelial cell media as well as recombinant CEACAM1 expressed in HEK293 cells stimulate proliferation, chemotaxis, and capillary-like tube formation of human microvascular endothelial cells. They increase vascularization of chick chorioallantoic membrane and potentiate the effects of vascular endothelial growth factor (VEGF)165. VEGF165 increases CEACAM1 expression both on the mRNA and the protein level. VEGF165-induced endothelial tube formation is blocked by a monoclonal CEACAM1 antibody. These data suggest that CEACAM1 is a major effector of VEGF in the early microvessel formation. Since CEACAM1 is expressed in tumor microvessels but not in large blood vessels, CEACAM1 may be a target for the inhibition of tumor angiogenesis.

Adenosine Triphosphatases↗
PubMed1999

CCR5 genotype and HIV-1 infection in perinatally-exposed infants.

The CCR5 chemokine receptor is required by non-syncytium HIV-1 strains to infect target cells. A 32 base pair deletion (delta32) in the CCR5 gene causes a structural CCR5 modification that does not permit HIV-1 entry into cells. The rate of the CCR5 delta32 was investigated in 137 children born from HIV-infected mothers. Overall, five (10.6%) of 47 HIV-infected infants showed the defect in heterozygosis vs. eight (8.9%) of 90 uninfected children. No CCR5 delta32 homozygotes were found. Interestingly, among infected children, five (21.7%) of 23 showing a slow disease progression were heterozygous for the CCR5 delta32, meanwhile none of the 24 infants with rapid disease course had the deletion (P = 0.022). In conclusion, the CCR5 delta32 defect does not protect against vertical HIV-1 transmission, but is associated with a delayed disease progression in HIV-infected children.

Female↗
PubMed1998

Is it HNPCC or HMRDS?

Explore the source record for details and available documents.

Colorectal Neoplasms, Hereditary Nonpolyposis↗
PubMed1997

Malaria in Honiara, Solomon Islands: reasons for presentation and human and environmental factors influencing prevalence.

During February and March 1995, out-patients attending health clinics and the Central Hospital in East Honiara, Guadalcanal, Solomon Islands, were surveyed with the aim of determining factors influencing the differing rates of malaria, the proportion of transmission occurring within the town, and the reasons for presentation. Three hundred and nine adult patients, who were sick and had blood smears taken, were asked about their general knowledge of malaria transmission. Of those interviewed, 120 were visited at their home in East Honiara, to determine variables. EpiInfo 5.1 was used in analysis. A history of fever alone was not a good indicator of parasitemia. Most precautions, including bed nets, window screens and personal precautions were of little benefit. Significant protection was afforded individuals and families with indoor kitchens. Patients not completing their antimalarial treatment fared worse in terms of parasitemia and malaria history. Most malaria/parasitemia was indigenous to Honiara. Many patients had a good knowledge of malaria transmission and mosquitos, but this did not translate into a lower rate of parasitemia or malaria.

Adolescent↗
PubMed1996

Malaria in Honiara, Solomon Islands: vector studies.

Adult and larval specimens of anopheline mosquitos were collected throughout eastern Honiara during a study into risk factors for malaria illness in adults. Species identification was by morphology, DNA probes and by PCR. Only Anopheles farauti s.s. were identified from part-night landing catches carried out from 1900 to 2200 hours. Most mosquitos attracted to humans were culicines. The majority of anophelines (85%) were captured between 1900 and 2000 hours. An. farauti s.s. larvae were most common but one An. farauti No. 7, and ten An. punctulatus larvae were also collected.

Adult↗
PubMed1995

Protective measure use and symptoms among agropesticide applicators in Sri Lanka.

Sri Lankan farmers use large amounts of pesticides to control the pests affecting their vegetable crops. Improper use of pesticides by farmers has resulted in poisoning of occupational origin. This paper examines the use of protective measures by pesticide applicators and its relationship to their illness symptoms. The data were collected by interviewing a stratified random sample of 150 farmers from predominantly vegetable growing areas of the Matale district during 1990/91 using structured questionnaires. These data were supplemented with secondary data and observation of all stages of pesticide application. Scales were constructed to measure the domains of material style of life, awareness and use of protective measures, and illness symptoms experienced by pesticide applicators. It was found that most of the farmers were aware of the protective measures to be used when applying pesticides. There was, however, no significant positive relationship between awareness and use of protective measures. The main reason for not using protective measures was discomfort. The most common symptoms reported by pesticide applicators were faintish feeling, headache and dizziness. A significant negative relationship was observed between use of protective measures and symptoms exhibited within four hours of application. It is recommended that protective materials adapted to the climate and socio-economic conditions of farmers be developed, and that farmers be encouraged to use these protective materials through appropriate educational efforts and incentives.

Adult↗
PubMed1991

Immersion warming of blood before transfusion.

We compared a simple method of warming stored blood by immersion of blood bags in warm water, to the standard method using portex blood warming infusion coils, which are not freely available in Sri Lanka. The mean temperature of blood after warming by immersion of blood bags was 29.5 degrees C and by infusion coil 30.2 degrees C. The values were within the confidence limits of each other. Ten units of blood in each group were compared with regard to changes in free haemoglobin (Hb), packed cell volume (PCV), and hydrogen ion concentration, and no statistically significant difference was observed. We recommend immersion warming as a safe and effective alternative to warming by infusion coil.

Blood Transfusion↗