Biomedical subjects

M Feran

Publications and source records attributed to M Feran.

3 recordsLinked to original sources

PubMed1987

Coxsackievirus B-3-induced myocarditis. Effect of sex steroids on viremia and infectivity of cardiocytes.

Male and female BALB/c mice were inoculated with various concentrations of coxsackievirus, group B, type 3 (CVB3), ranging from 10 to 10(7) plaque-forming units (PFU). Lower viral doses (greater than 10(2) PFU) induced severe myocarditis in male mice but caused little injury in females. With 10(7) PFU, females also developed severe disease. Females may be relatively resistant to CVB3-induced myocarditis because virus entry into the blood and heart is less effective. Males given 125I-CVB3 show approximately 2-4 and 20-fold more radioactivity in the peripheral blood and heart, respectively, than females. No differences were observed between the sexes in 125I-bovine serum albumin penetration. Sex steroid hormones influence viremia and virus localization; females given exogenous testosterone and progesterone demonstrate ten times more virus in their hearts than animals given estradiol. The hormones may act by increasing virus receptor expression on endothelial cells and myocytes.

Animals↗

PubMed1987

Anomalous 2-deoxyglucose uptake and acetylcholinesterase activity in cat LGN after optic chiasm section.

Sectioning the optic chiasm in young kittens denervates layer A of the lateral geniculate nucleus (LGN) on both sides of the brain. We removed one eye of these split chiasm kittens in adulthood, rendering the ipsilateral LGN devoid of primary retinal input. Nonetheless, one day after the eye removal, consumption of 14C-2-deoxyglucose (2-DG) was much higher in layer A than in layer A1 of the LGN. The anomalous 2-DG uptake was not due to enhanced cortico-geniculate or other visual input to layer A, but instead appears related to a marked increase in acetylcholinesterase activity in this layer following the early chiasm section.

Acetylcholinesterase↗

PubMed1981

[Interhemispheric competition during postnatal development].

The corpus callosum is a bidirectional pathway interconnecting the visual cortices on the two sides of the brain. Rearing kittens with the optic chiasm sectioned and one eyelid sutured during early development results in a functional asymmetry in this pathway. Visual input originating on the side of the brain ipsilateral to the sutured eye looses the ability to influence cells on the other side of the brain. Conversely, visual input originating on the side of the brain ipsilateral to the exposed eye markedly increases its influence in the other hemisphere. These physiologic findings are paralleled by anatomic results indicating that the terminal field of the corpus callosum is markedly expanded in the cortical hemisphere ipsilateral to the deprived eye and reduced in the other hemisphere.

Aging↗