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Biomedical subjects

M Feinsod

Publications and source records attributed to M Feinsod.

At least 55 records · Page 3Linked to original sources
PubMed1995

[Head injuries in the Bible].

3 cases of head injury are described in the Bible: the death of Sisera by the hand of Jael (Judges 4: 21; 5: 25); the skull fractures of Avimelech incurred at the tower of Tevetz, (Judges, 9: 53, 54); and the slaying of Goliath by David, (Samuel I 17: 49-51). The various attempts to understand the mechanisms of these head injuries using philology, knowledge of the art of biblical warfare and modern medical considerations are reviewed. We try to identify the site of the mortal blow to Sisera's head, to understand why Avimelech asked to be killed, and to decide whether the giant from Gath was a rugged warrior or just an endocrinological cripple.

Bible↗
PubMed1995

Motor and somatosensory conduction in cervical myelopathy and radiculopathy.

STUDY DESIGN: Motor and sensory conduction times were measured in patients with cervical myelopathy and radiculopathy. The results were compared with those of control subjects. OBJECTIVE: To evaluate the clinical value of the combined use of motor-evoked potentials with F wave recording and somatosensory-evoked potentials in cervical myelopathy and radiculopathy. SUMMARY OF BACKGROUND DATA: Electromyography and somatosensory-evoked potentials provide only indirect information on the motor pathways. The development of magnetic transcranial stimulation has provided a direct and reliable physiologic insight into the motor system. METHODS: Magnetic stimulation of the motor cortex and nerve roots with F wave recording was used to assess central and peripheral motor conduction times. Somatosensory conduction was evaluated by somatosensory-evoked potentials. RESULTS: Significant prolongation of the central sensory and motor conduction times was found in the group with myelopathy. These findings were much more pronounced in patients who had multiple level spondylotic stenosis of the spinal canal than in those harboring a single disc herniation compressing the spinal cord. In contrast to somatosensory-evoked potentials, motor-evoked potentials combined with F wave recording showed marked impairment of peripheral conduction in patients with radiculopathy. CONCLUSION: Motor-evoked potentials associated with F wave recording was suitable for the evaluation of patients with radiculopathy. The severity of conduction impairment in patients with myelopathy can be assessed by combined motor-evoked potentials and somatosensory-evoked potentials.

Adult↗
PubMed1995

[Microvascular decompression of the trigeminal nerve: electrophysiological changes].

In a 67-year-old woman with trigeminal neuralgia, pressure on the trigeminal nerve of vascular bundle and arachnoidal adhesions was relieved by microsurgery. Short-latency, brainstem, trigeminal evoked-potentials were continuously recorded throughout the operation. The initial response was characterized by prolonged latency, low amplitude and distorted shape. Immediately after decompression the response attained normal latency, amplitude and shape. Pain disappeared within less than 24 hours. Power spectrum analysis showed wide frequency range in the initial evoked potentials, consistent with desynchronization of the afferent impulses. The range of frequencies was reduced to normal as soon as the trigeminal nerve was decompressed.

Aged↗
PubMed1995

[Short-latency, brainstem, trigeminal evoked-potentials].

Short-latency, evoked-potentials were recorded from over the scalp in response to electrical stimulation of the upper lip, using the Microshev 4000 equipment (Microshev Co., Efrat). Normative data were obtained from 35 normal volunteers. The brain-stem, trigeminal evoked-potentials (BTEP) consisted of 4 distinct, well-reproduced waves evoked in less than 10 msec. The waves, named after their respective latencies, are thought to be generated in the preganglionic trigeminal nerve (T1), the postganglionic nerve entry zone (T2), in the trigeminal nucleus (T3) and the upper brainstem (T5). BTEP was recorded in nearly 200 patients suffering from various lesions in the peripheral trigeminal parts, tumors affecting the brainstem (before, during and after surgery) and in varying degrees of post-traumatic coma. BTEP proved to be a reliable tool for evaluating the brainstem trigeminal system; changes in its pattern reliably reflected altered activity of that system. It can be used for diagnosis as well as for intraoperative monitoring of brainstem function.

Brain Diseases↗
PubMed1995

[Head injury in the elderly].

We report 281 consecutive admissions of head-injured patients over 65 years of age. 2/3 were males, as in younger age groups, despite the decreased activity and increased proportion of females among the elderly. The main causes of injury were falls (71.8%; mostly at home) and pedestrian accidents (20.6%). There was a high incidence of cardiovascular disease among the men. The unique set of causes and types of head injuries in this age group (1/3 chronic subdural hematomas, 1/3 cerebral contusions and 1/5 acute subdural hematomas), as well as the grim outcome, justify regarding head injury in the elderly as a special clinical entity. Its special medical, surgical, organizational and ethical aspects should be considered.

Accidental Falls↗
PubMed1995

[Head injuries from falls in children of 2 ethnic groups].

The highly prevalent problem of falls, the main cause of head injury in children, responds to preventive intervention. To aid in designing fall-prevention programs, we defined the pre- and post-hospitalization characteristics of children of 2 predominant Israeli ethnic groups: Jews (Group A) and non-Jews (Group B). In a prospective study conducted over a 10-month period in our emergency room during the morning shift, data from 274 patients aged 0-14 who presented with head injury due to a fall were collected. In Group B falls and damage were significantly more severe. Based on these differences in injury and in referral patterns between the 2 groups, a high-risk profile for head injury from falls in children was compiled to aid in designing an effective prevention program.

Accidental Falls↗
PubMed1994

[Visual hemineglect as presenting symptom of right parietal tumors].

4 patients with malignant right parietal brain tumors (2 with gliomas and 2 with metastases) presented with difficulties in driving due to visual hemineglect, thought at first to be due to absent-mindedness or forgetfulness. Visual neglect is one aspect of the syndrome of unilateral neglect, which is a selective disturbance in the internal representation of the body image and processing of information from the extrapersonal space. The cerebral mechanisms underlying the phenomenon are reviewed.

Aged↗
PubMed1993

A physiological coma scale: grading of coma by combined use of brain-stem trigeminal and auditory evoked potentials and the Glasgow Coma Scale.

Forty-five comatose patients were prospectively studied by means of clinical examination and evoked potentials. In each patient, clinical data included Glasgow Coma Scale (GCS) score, age, pupillary response to light, corneal reflex, and eye movements. Neurophysiological evaluation was based on brain-stem trigeminal evoked potentials (BTEPs) and brain-stem auditory evoked potentials (BAEPs). For each physiological test, a progressive grading system was designed. This system was based on the evaluation of central conduction times along the trigeminal and the auditory pathways within the brain-stem. The accuracy of the clinical and the neurophysiological indicants in predicting "favorable" or "unfavorable" outcome was assessed singly and in combination. Of the clinical indicants, the GCS provided the most accurate prognosis (80%). Similar results were provided by the BAEP and the BTEP, with significant improvement in the confidence of outcome prediction. No significant difference in the accuracy of outcome predictions could be found between combined clinical data and neurophysiological data. However, the combination of clinical and neurophysiological data markedly increased both the accuracy and the confidence of outcome prediction, reaching 86% correct predictions at the over 90% confidence level with only 2% false pessimistic errors. According to these findings, a clinical-physiological coma scale, the trigeminal-auditory Glasgow (Coma Scale) score (TAG score) was designed. The TAG score demonstrated the highest accuracy at each confidence level as compared to other single indicants. We concluded that the TAG score may improve the evaluation of deep comatose patients and assist the physician in the management of such patients.

Adolescent↗
PubMed1993

Real-time monitoring of visual evoked potentials.

Steady-state visual evoked potentials (SSVEP) were recorded in response to flashes from eyepatch-mounted light-emitting diodes during neurological surgery and in the intensive care unit. SSVEP were detected and measured with a microprocessor-based waveform correlator. The system enabled a continuous display, in real time, of SSVEP amplitude and latency. SSVEP amplitude and latency changes were monitored throughout a variety of surgical procedures. Some of these procedures directly affect the central visual pathway, some affect the central nervous system as a whole, while others do not affect central nervous system function. In addition, intensive care unit patients with a variety of intracranial pressures were monitored. The results of this study indicate that SSVEP recorded with this method showed changes in SSVEP within seconds of surgical and/or medical decompression of intracranial pressure and were sensitive to specific changes in the visual pathway. Surgical procedures that directly affected the visual system, or elevation of intracranial pressure, resulted in changes in SSVEP. In contrast, procedures that did not affect the functional integrity of the visual system did not affect the recordings.

Adenoma↗
PubMed1992

[Brain abscess following skull traction].

A case of brain abscess developing after skull traction for fracture of the dens is presented. The abscess was most likely caused by retrograde septic thrombophlebitis via the superficial cortical veins. The abscess was drained and treatment with antibiotics was according to sensitivity on culture. 3 months after surgery there was mild residual paresis of the left hand. The need for close follow-up of patients prone to this complication is emphasized.

Adult↗
PubMed1992

Effect of histamine H2 receptor antagonists on the secretion of cerebrospinal fluid in the cat.

Following a recent report that epithelial cells of the choroid plexus possess histamine H2 receptors, the effect of cimetidine and ranitidine, histamine H2 receptor antagonists, on the secretion and electrolyte content of CSF was examined. Fifty cats were divided into one control (n = 6) and six experimental groups. CSF was collected by puncture of the cisterna magna following pentobarbital anesthesia, and its volume, concentrations of Na+, K+, Cl-, and pH were determined. Cimetidine or ranitidine (50, 20, or 10 mg/kg) was injected intravenously 2 h after the start of the test, and their concentrations were measured in hourly blood samples and in 30-min aliquots of CSF in the 50 mg/kg experimental groups. Whereas the secretion of CSF did not change over 6 h in the control group, it decreased significantly by 30-60 min after injection of cimetidine or ranitidine and remained low for the following 6 1/2 h in all experimental groups except the 10-mg ranitidine group. Peak cimetidine and ranitidine concentrations in CSF in the 50-mg experimental groups were noted 60 and 90 min, respectively, after intravenous injection. CSF electrolyte concentrations and pH did not change during the test in any group. We conclude that intravenous cimetidine or ranitidine can significantly reduce CSF secretion in the cat, possibly by competitive inhibition of the histamine effect on H2 receptors located on the choroid plexus epithelial cell, or by a direct effect on the capillaries of the choroid plexus.

Animals↗
PubMed1991

Development of auditory brainstem evoked potentials in newborn infants: a three-channel Lissajous' trajectory study.

Auditory brainstem evoked potentials (ABEP) were recorded from 50 newborns (35-43 weeks gestational age), using three orthogonal differential electrode pairs, in addition to the widely used vertex-mastoid derivation. Potentials were evoked by alternating polarity, 75 dBnHL clicks presented monaurally at a rate of 10/s. From the records of the three orthogonal electrode pairs (nasion-inion; vertex-spinous cervical process VII; left-right mastoids), Three-channel Lissajous' trajectories (3CLT) were derived and analyzed. 3CLT point-by-point, as well as segmental descriptors were compared with peak latencies of the vertex-mastoid derivation. Point-by-point 3CLT descriptors included apex amplitude, latency and orientation. Segmental descriptors included planar segment beginning latencies, duration and orientation. The interpretation of these results in relation to developmental aspects of the auditory system, as well as to the question of ABEP generators, is enhanced by using 3CLT descriptors of ABEP, which are more comprehensive than their single-channel counterparts. 3CLT apices correlated well with the Vertex-Mastoid defined peaks. Both peak and apex latency changes indicate that at the developmental stages surveyed in this study, development takes place in the more central portions of the pathway, whereas the peripheral portion is already relatively mature. The results also indicate a maturational change in the relative contributions of constituent generators of ABEP components.

Brain Stem↗
PubMed1991

The association between skull fracture, intracranial pathology and outcome in pediatric head injury.

We prospectively studied 653 consecutive head-injured children (less than or equal to 14 years old) treated over a 54-month period (1984-88) at the Department of Neurosurgery of the Rambam Medical Center (Haifa, Israel). Demographic and clinical data were collected, the patients were divided into five age groups (birth to 2 years, 169; 3-5 years, 194; 6-9 years, 164; 10-12 years, 77; and 13-14 years, 49), and the information relative to each was then compared. All patients (except three who died on the operating table) underwent computed tomography (CT) scans; 225 (34.6%) had intracranial pathology, e.g. focal mass lesions, diffuse axonal injury, and subarachnoid haemorrhage. The rate of detected pathology increased with age. Skull fracture was documented in 468 (72%) patients. Craniotomies were done on 114 (17.5%) patients. After 3 months, the patients were classified as having good recovery (84.8%), moderate disability (5.5%), or severe disability (2.3%); 0.9% were in a vegetative state. The mortality was 6.6% (43 patients); of these, 39 (90.7%) had admission Glasgow Coma Scale scores below 8. In our area the annual incidence of neurosurgical hospitalization due to head injury in the pediatric group was 37.6 per 100,000 inhabitants per year. This study substantiates the findings of other series on the effects of prognosis of factors such as associated trauma, admission Glasgow Coma Score, mass lesions with persistent intracranial pressure elevation, or diffuse axonal injury.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1991

Penetrating craniocerebral injuries in civilians.

During a 6-year period (1984-89), 31 patients were treated at Rambam Medical Center with penetrating craniocerebral injuries (PCCI) not associated with military action. Eighteen (58%) patients died during their initial hospitalization; only two of them had admission Glasgow Coma Scale (GCS) above five. The admission GCS coupled with the mode of injury (type of missile and motivation of shooting) were valuable for early accurate prognosis assessment. Patients with admission GCS of 3 and 4 invariably died despite rapid treatment and attempted haematoma evacuation. The neurological status, CT appearance, as well as the motivation of shooting should be considered in order to assess accurately the possible outcome. Compared with our military series of 113 patients with PCCI, there were more extensive injuries, although the mean period until neurosurgical treatment was the same. Long-term complications connected to dural tears remote from the entrance wound occurred in three of the survivors.

Adolescent↗
PubMed1990

[Head and brain injuries in bicyclists].

44 patients were hospitalized for neurosurgical care after bicycle accidents during a period of 50 months. Ten times as many were injured in other types of road accidents. 42 of the 44 cases had brain injury, with a mean hospitalization of 9.7 days. A third needed operation and a fourth were discharged with residual neurological deficits. The low incidence of 0.95 cases per 100,000 per year led us to examine the factors which limit the use of bicycles in our region. The severity of the injuries in our cases was much greater than in those in other countries, with a mean injury severity score of 14.2. None of our cases had worn a protective helmet, and we join in the world-wide plea for an educational campaign for their use.

Bicycling↗