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Biomedical subjects

M Feinmesser

Publications and source records attributed to M Feinmesser.

At least 55 records · Page 3Linked to original sources
PubMed1993

Progressive hearing loss in hard-of-hearing children.

A group of 92 children with bilateral sensorineural hearing loss has been followed up over a period of up to 15 years from the time that an initial reliable audiogram was obtained. This group was studied in order to determine the frequency of occurrence of progressive hearing loss and the relationship of the progressive to the presumed etiology of hearing loss. Progression of hearing loss was demonstrated in 21 children out of the 92 children studied. This progression of hearing loss was either bilateral or unilateral, and no evident relationship could be found between the presumed etiology of hearing loss and its progressivity.

Audiometry, Pure-Tone↗
PubMed1993

A monomorphic adenoma of the minor salivary glands presenting at the base of the tongue: a case report and review of the literature.

A case of a monomorphic adenoma of the minor salivary glands situated at the base of the tongue in a 49-year-old female is reported. The patient had a prolonged clinical course of eight years' duration. The histopathologic, immunohistologic and ultra-structural findings are described. A review of the literature concerning minor salivary gland tumors and their location in the oral cavity is presented. This is the first case, to our knowledge, of a monomorphic adenoma presenting at the base of the tongue. The difficulties in its diagnosis are discussed specifically in regard to its location.

Adenoma↗
PubMed1992

Detection of occult nasopharyngeal primary tumours by means of in situ hybridization.

Detection of nasopharyngeal carcinoma primaries in patients presenting with neck node metastases may sometimes demand considerable efforts. By using the 'in situ hybridization' technique, we manage to identify the Epstein-Barr virus in neck metastases secondary to nasopharyngeal carcinomas. We propose that such identification in neck node metastases where the primary lesion is unknown indicates a nasopharyngeal primary.

DNA, Viral↗
PubMed1992

Fine structure of adrenal cortex in rats harbouring a medullary thyroid carcinoma transfected with a corticotrophin-releasing hormone cDNA expression vector.

We report the light microscopic, transmission and scanning electron microscopic features of the adrenal cortices in rats bearing a medullary thyroid carcinoma cell line transfected with a corticotrophin-releasing hormone (CRH) cDNA expression vector. The animals had elevated CRH, ACTH and corticosterone blood levels, involuted thymuses and markedly enlarged adrenal glands with prominent lipid-depleted cortices and dilated congested capillaries, similar to those of animals treated with ACTH. Using electron microscopy it was found that the enlarged fasciculata and reticularis zones were composed of large, compact cells with abundant smooth endoplasmic reticulum, prominent Golgi complexes, increased number of large mitochondria with focal loss of cristae and cavitation of the internal compartments, numerous lysosomes and prominent elongated microvilli. In addition, small cytoplasmic fragments were seen within the capillary lumina; these structures resembled microvilli that were apparently detached from adrenocortical cells and entered the blood stream via discontinuous endothelium of dilated capillaries. By scanning electron microscopy it was found that the cells had bulging surfaces with scattered pits and numerous long microvilli pointing in different directions. This animal model allows analysis of the effects of protracted CRH excess resembling tumoural CRH-dependent Cushing's syndrome in human patients. Our findings call attention to the role of microvilli in adrenocortical secretion. The increased number and size of microvilli has been thought to lead to an increase in the surface area of adrenocortical cells, thereby facilitating hormone discharge. The detachment of microvilli from adrenocortical cells may represent a form of apocrine secretion and may contribute to hypercorticosteronaemia in CRH excess.

Adrenal Cortex↗
PubMed1991

Central effects of cycloheximide alone and of its combination with T-2 toxin.

The antibiotic cycloheximide inhibits protein synthesis in eukaryotic cells. This overall effect is similar to that of T-2 toxin, but the mechanism of intoxication by these two inhibitors are different. This is shown here by intracerebral injections of mixtures of T-2 toxin and cycloheximide, leading to potentiation of their toxic effects. The histopathology of cerebral intoxication by the two compounds is similar, but after cycloheximide the lesions appear earlier, and repair is faster.

Animals↗
PubMed1991

Liposarcoma of the nasopharynx: a case report.

We present a case of liposarcoma of the nasopharynx in a 28-year-old woman. The tumor was incompletely resected through an intraoral approach and supplementary radiotherapy of 50 Gy in a restricted field was therefore administered. Eleven years of follow-up show the patient to be disease free.

Adult↗
PubMed1990

Decline in the prevalence of childhood deafness in the Jewish population of Jerusalem: ethnic and genetic aspects.

A longitudinal study was performed on 147 Jewish children with bilaterally sensorineural hearing loss of moderately severe to profound degree, born in Jerusalem during the eighteen years 1968-85. The prevalence rate of these children declined during the years 1977-85, and at the same time the rate of consanguinity of their parents decreased; this decline was more evident in the genetic group among children with non-Ashkenazi ethnic origin. No such decline was found among the Ashkenazi children and no consanguinity among parents of these children was recorded. Our study supports the assumption that restriction of consanguineous matings may affect the prevalence of genetic deafness in children in a well-defined population. We have tried to remain unbiased and concede certain shortcomings in our present study.

Consanguinity↗
PubMed1989

The long-term predictive value of the zona-free hamster ova sperm penetration assay.

Three hundred sixty-nine infertile couples were followed for 2 to 5 years in a study designed to determine the clinical long-term predictive value of the zona-free hamster ova sperm penetration assay (SPA). Semen analysis (SA), SPA, and a full infertility workup were done in all cases, and only couples in whom the female had no evident cause of infertility were included in the study. During the follow-up period, 106 couples (29%) achieved a pregnancy. Sixteen percent of 131 men who had an SPA of 0%, 23% of 120 men with 1% to 19%, and 48% of 118 men who had a penetration of greater than 19% impregnated their wives 2 to 5 years after the assays. Significant difference in fertility prognosis was found between those who had an SPA greater than 19% and those with an SPA less than 20% (48% versus 20%). Sperm penetration assay greater than 19% was predictive of higher pregnancy rates in both oligospermic (41% versus 17%) and unexplained infertile couples (52% versus 24%). The specificity and positive predictive values of the SPA were higher than those of the SA (77% versus 57% and 48% versus 37%). These findings emphasize the value and importance of the SPA in determining the long-term fertility potential of men.

Animals↗
PubMed1989

Consanguinity among parents of hearing-impaired children in relation to ethnic groups in the Jewish population of Jerusalem.

A longitudinal study was performed on Jewish children with moderately-severe to profound hearing impairment born in Jerusalem during a period of 15 years (1967-1982), and the data on consanguineous matings among their parents were analyzed. These data were estimated in relation to the records obtained in an earlier survey performed on Jewish deaf children during the years 1955-1964. The rate of consanguinity among the parents of hearing-impaired children was much lower in the present survey than in the earlier one in both the Ashkenazi (Central and Eastern European origin) and the non-Ashkenazi (Asian-African origin) group. It is assumed that there is a better understanding of the genetic risk in consanguineous unions, especially when a disability such as hereditary deafness is involved.

Consanguinity↗
PubMed1986

Etiology of childhood deafness with reference to the group of unknown cause.

A systematic follow-up of children diagnosed as deaf may reveal additional pertinent information which may be instrumental in ascertaining the cause of deafness. 107 deaf children were detected by a prospective study of 62 000 children screened for deafness during 11 years. The cause of deafness could be determined in 63 children while in 44 no etiology was apparent. Investigation of the 44 children revealed a genetic origin of deafness in 12 additional children. Consanguinity was evident in the children whose deafness was of genetic origin. Identification of the cause of deafness in children contributes to prevention of this handicap.

Consanguinity↗
PubMed1983

Early detection of hearing loss in infants by auditory nerve and brain stem responses.

Auditory-nerve and brain-stem-evoked responses (ABR) have been used alongside standard behavioral hearing tests for the early detection of hearing loss in infants and young children. Two comparisons are presented. The first concerns a group of 65 hearing-impaired children for whom we now have complete pure-tone and speech audiograms. There is a good correlation between the two types of hearing tests in 61 children; the lack of correlation in 4 children is discussed. The second comparison was conducted on neonates. Because ABR testing provides information which is far more accurate than behavioral testing, it is recommended for use in high-risk neonates, especially when mass behavioral screening is not feasible.

Audiometry↗
PubMed1982

Follow-up of 40,000 infants screened for hearing defect.

During a 7-year period beginning in 1967, approximately 40,000 infants born in Jerusalem were screened for hearing impairment. The hearing of all infants who visited the well-baby clinics at the age of 7-9 months (85% of the child population) was tested and a set of selective criteria was applied to them to detect the children at risk of hearing impairment. Those children suspected of having a hearing impairment were followed up at the Speech and Hearing Center of the Hadassah University Hospital. 69 children were identified as having substantial hearing impairment (moderate to profound); the distribution of risk factors among them is presented. Rehabilitation was carried out from infancy to preschool age, at which time the children were enrolled in suitable educational frameworks. The role of the parents was crucial. At the age of 6 years, many of the hearing-impaired children were integrated into the elementary school system; others attended the School for the Deaf or special institutions. The distribution of the hearing-impaired children in the various school systems is discussed.

Child, Preschool↗
PubMed1977

Screening for hearing impairment in early childhood.

Hearing screening for early detection of deafness in children was carried out in the Jerusalem area during 5 years (1967-1972). Approximately 27,000 infants 5-7 months old, representing 85% of the children population at this age, were screened in baby clinics and a selective 'at risk' register was applied to them. Testing hearing in baby clinics was easy to implement and economical but not infallible. About 50% of the 43 hearing-impaired children were identified during the 1st year of their life at an audiology center. A careful and efficient screening and follow-up could identify 70% of the deaf children. We recommend to apply the hearing screening and selective 'at risk' register to children 7-10 months old. It is suggested to expand hearing screening to 2- to 3-year-old children.

Deafness↗
PubMed1976

Neonatal screening for detection of deafness.

To assess various methods of early detection of deafness, a longtudinal study of infants born in the Jerusalem area was performed. The 17,731 newborns were tested by an acoustic signal generator hearing test (Apriton), and the "at risk" for deafness register was applied to them. Twenty-five children were identified as deaf, 14 with severe or profound hearing loss and 11 with moderate or moderately severe loss. The screening hearing test did not prove to be sensitive enough for detection of deafness in newborns, and, therefore, is not considered valid for screening purposes. The at risk for deafness register, which in our program covered 20% of the entire newborn population, proved to be to expensive and impractical; a restricted register, including approximately 7% of the newborns, is suggested.

Acoustic Stimulation↗