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Biomedical subjects

M Feinleib

Publications and source records attributed to M Feinleib.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

ABO blood group and cardiovacular disease: the Framingham study.

Following determination of ABO blood type at the sixth biennial examination, the Framingham Heart Study cohort was followed for the occurrence of cardiovascular events for a period of 10 years. A significant association was found between blood type and intermittent claudication, with blood group O showing the lowest rates. Slight but non-significant excesses for certain other CHD events were also found in non-O individuals. Serum cholesterol showed marginally significant but consistent elevations in non-O subjects but the increased risk in non-O individuals was found to occur independently of the known intermittent claudication risk factors. Since the observed relationship between blood type and intermittent claudication occurs independently of the usual atherosclerotic risk factors, blood type, possibily through an effect on clotting, should be considered in the pathogenesis of intermittent claudication.

ABO Blood-Group System↗
PubMedDate not supplied

Joint distribution of lipoprotein cholesterol classes. The Framingham study.

During the period 1971 to 1975, the cholesterol content of lipoprotein density classes were measured in 2415 male and female Framingham Heart Study participants and 4342 of their offspring and offspring spouses who were free of coronary heart disease. In this first of three papers, the univariate and bivariate distributions of high density lipoprotein cholesterol, low density lipoprotein cholesterol, and very low density lipoprotein cholesterol are presented. There are differences in the levels of lipoprotein cholesterols by age, gender, and use of hormone preparations. The bivariate cross-tabulations of the three pairs of lipoprotein cholesterol measurements exhibit properties that cannot be appreciated from univariate summary statistics and suggest the importance of joint consideration of different lipoprotein cholesterol patterns for assessing the risk of coronary heart disease.

Adolescent↗
PubMedDate not supplied

Serum triglyceride and risk of coronary heart disease, stroke, and total mortality in Japanese-American men.

The role of serum triglyceride as a risk factor for coronary heart disease (CHD), stroke, and total mortality was examined in men of Japanese ancestry who were 45 to 78 years old. During the first 10 years following a baseline nonfasting triglyceride determination, there were 490 incidence cases of CHD in 7615 men at risk. Average annual incidence rates were 2.1 times higher in men with nonfasting values above the 75th percentile (279 mg/dl) than in those under the 25th percentile (129 mg/dl, p less than 0.001). This association largely disappeared when associations of triglyceride with other CHD risk factors were accounted for. Fasting triglycerides were measured in a representative sample of 1729 men part-way through the study. With an average follow-up of 5.7 years there were 72 new CHD cases in this group with the risk for men in the top quartile (above 195 mg/dl) being 1.9 times higher than for those in the bottom quartile (below 94 mg/dl). This gradient was of borderline significance (p less than 0.10) and completely disappeared in a multivariate analysis which included HDL and other factors. It appears that the association of triglyceride with CHD in this cohort is of a noncausal nature. Triglycerides were not predictive of stroke or of total mortality in these men.

Aged↗
PubMedDate not supplied

Epidemiology and genetics of hypertension.

The major decline in cardiovascular mortality during the last 20 years may be related to improved hypertension control, but a causal relationship has not been proven. Fundamental epidemiologic associations between age, sex, race, socioecomonic class, and blood pressure (BP) have been well characterized. Risk of coronary heart disease and stroke mortality and morbidity is linearly related to BP or to categorically defined hypertension. Weight is a major correlate of BP at all ages and in most populations. The relationships between hypertension and other nutritionally related factors are not so well defined. The Framingham Study (both cohort and offspring components) provides information about other BP correlates such as heart rate and clinical chemistry values as well as evidence suggesting a genetic influence on BP variability in families. Combined with observations from other studies, it appears that heredity plays a very important role in human hypertension.

Adolescent↗
PubMedDate not supplied

The British-Norwegian migrant study: 5-year mortality differentials due to cigarette smoking.

Cigarette smoking and 5-year survivorship of 20,017 British and 10,016 Norwegian migrants to the United States were compared with 17,696 British and 26,155 Norwegian nonmigrants. The highest mortality ratios for 5-year age-adjusted death rates observed were of cigarette smokers to nonsmokers, ranging from 1.40 to 1.60 for men and from 1.18 to 1.36 for women. Mortality ratios of nonmigrants to migrants ranged from 1.07 to 1.19 for men and from 1.22 to 1.36 for women. Mortality ratios for British to Norwegian groups ranged from 1.13 to 1.27. Some differences in mortality ratios for cardiovascular diseases contrasted with mortality ratios for noncardiovascular diseases were noted. The most important of these differences was the apparent lack of any consistent difference between nonmigrants and migrants in their 5-year cardiovascular mortality rates, although there were consistent differences for noncardiovascular diseases.

Adult↗