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Biomedical subjects

M Feely

Publications and source records attributed to M Feely.

64 records · Page 4Linked to original sources
PubMed1977

The effects of toxic and non-toxic serum phenytoin levels on carbohydrate tolerance and insulin levels.

The effect of toxic and non-toxic phenytoin levels on carobhydrate tolerance and insulin levels was studied in 18 patients with epilepsy and 17 control subjects. Toxic levels were defined as a serum level greater than 20 microgram/ml. Toxic levels occurred in 11 patients and nontoxic levels in seven patients. Blood glucose and insulin levels were measured at 30-min intervals for a period of 3 h following the ingestion of 50 g glucose. Blood glucose levels were measured by the ferricyanide method, and serum insulin levels by immunoassay of insulin with insulin antibody precipitate. Serum phenytoin levels were measured by gas liquid chromatography. The insulin profiles were the same for all three groups, but there was a significant delay in reaching peak glucose concentrations in patients with toxic levels of phenytoin. It was therefore confirmed that non-toxic levels of phenytoin do not affect carbohydrate tolerance or insulin levels when phenytoin is used in the routine treatement of epilepsy, and it has also been shown that toxic levels of phenytoin do not affect carbohydrate tolerance when the high levels are detected at an early stage.

Adolescent↗
PubMed1977

Relapsing neurological disorder associated with rubella virus infection in two sisters.

A disseminated relapsing neurological disorder presented simultaneously in two sisters. Encephalitic features were present in one case. The illness was associated with a significant increase in rubella specific IgM in both sisters. Despite the absence of a rubella rash, this increase would be compatible with a recent infection by the rubella virus as a basis for the illness, and the persistent elevation, with active antigenic stimulation. It is suggested that both patients might represent the clinical manifestations of perivenous demyelination caused by the rubella virus, which, in view of the relapsing nature of the illness, has progressed to plaque formation.

Adolescent↗
PubMed1976

Experimental carotid-basilar bypass.

A procedure for anastomosing the carotid to the vertebrobasilar circulation in the dog is described. A total of 20 experiments (10 acute and 10 chronic) were performed on dogs. The grafted vessel was found to be patent in 2 out of 4 dogs at 3 months after operation. The flow through the grafts, recorded by electromagnetic flowmeter, was 5-9 ml/min.

Animals↗
PubMedDate not supplied

Use of 'very low-dose phenobarbital' to investigate compliance in patients on reducing doses of methadone (detoxification).

Incorporation of very low doses of phenobarbital into a methadone linctus has enabled us to monitor the compliance of 7 patients receiving a reducing dose of methadone (detoxification) for treatment for opioid addiction. By measuring both plasma phenobarbital and methadone we detected 4 patients who consumed extra illicitly obtained methadone during the detoxification regime. Treatment outcome was poor; 11 of the original 18 patients dropped out of treatment within 14 days and of those who remained, 4 patients relapsed and reabused illicit drugs and 2 returned to a fixed dose of methadone. Laboratory measurements were successfully used to detect poor methadone compliance.

Adult↗
PubMedDate not supplied

Studies on the clinical pharmacokinetics of imidazopyrazole.

Plasma decay kinetics were analyzed for seven patients (400-5700 mg) during a Phase I clinical trial of imidazopyrazole. A two-compartment open pharmacokinetic model was able to account for the data. The median alpha-phase half-life was found to be 0.65 hour, with a median beta-phase half-life of 23.1 hours. Twelve per cent of the administered drug was excreted unchanged in 72 hours, whereas the total amount of imidazopyrazole equivalents excreted in that period was 38.6%. The median plasma equivalent space was found to be 15.9 l./m2, and volume of distribution at steady state was 40.2 l./m2. Renal and plasma clearance for imidazopyrazole was found to be 0.2 and 1.7 l./m2/hr, respectively.

Antineoplastic Agents↗
PubMedDate not supplied

[Using Peplau's theory in the nurse-patient relationship].

In caring for a person suffering from depression, Peplau's theory of "Interpersonal Relations" was found to be both effective and representative of what psychiatric nurses do. Peplau's work, initially published in 1952, continues to offer a major contribution to nursing knowledge and deserves the significance ascribed to it in the 1990s. Below, a report on the learning experience for both the patient and the carrier.

Depression↗
PubMedDate not supplied

Using Peplau's theory in nurse-patient relations.

In caring for a person suffering from depression, Peplau's theory of "Interpersonal Relations" was found to be both effective and representative of what psychiatric nurses do. Peplau's work, initially published in 1952, continues to make a major contribution to nursing knowledge and deserves the significance that it is being given in the 1990s. Below, a report on the learning experience for both the patient and the carer.

Depressive Disorder↗