[Notes on diet during the time of Cervantes].
Explore the source record for details and available documents.
Diet↗
Biomedical subjects
M Farriol
Publications and source records attributed to M Farriol.
[Preoperative chemotherapy and total parenteral nutrition in colon cancer].
AIM: The objective of this study was to determine the effect of TPN after surgery in patients with colon carcinoma and preoperative chemotherapy. MATERIAL AND METHOD: The study included 27 patients, 16 men and 11 women, with a mean age of 62.1 +/- 11.2 years. The patients were divided into two groups according to whether they had undergone chemotherapy (Group A; n = 11) or not (Group B, control; n = 16) prior to surgery. Almost two thirds of the patients were in stage III of the disease. Among those receiving this treatment, 60% were given 5-fluorouracil plus leucovorin at a dose of 5.5 +/- 2.7 cycles/patient and the others received different regimens. TPN was established early with a mean of 11.7 +/- 9.2 days. The clinical and nutritional assessment was performed before surgery and at the end of TPN administration. RESULTS: The mean body mass index (BMI) was 24.1 +/- 2.2 kg/m2. Comparison between the groups before the start of TPN showed statistically significant differences in red blood cell and platelet counts (P = .013 and P = .02, respectively). These differences had disappeared at completion of TPN, suggesting that this treatment can reverse the hematological changes induced by chemotherapy. CONCLUSION: In patients who receive chemotherapy before surgery and in whom TPN it was indicated the combination of these two treatments could be beneficial.
Colonic Neoplasms↗
Past and current trends in soy supplementation: a bibliographic study.
The aim was to determine in what areas the therapeutic application of soy predominates in clinical trials and to assess the emerging fields of its use by means of an analysis of bibliographic resources. A search was performed in the MEDLINE database up to 31 december 2004, limited to the Title/Abstract field, and Clinical Trials as the type of publication. The abstracts from the publications selected (n=86) were reviewed and different variables were assessed. A total of 3280 subjects were included: 15% men and 59% women (71% postmenopausal). The studies were performed basically in healthy individuals (71%). Twenty five percent of the studies investigated plasma levels of different metabolites and 21% determined hormone or lipid profiles. After the year 2000 a new population focus was detected, with the publication of two studies in elite gymnasts and judoists, with positive results. The present observations indicate that soy supplementation in the competitive sports elite may be an emerging application.
Adult↗
[Nutritional support in liver transplantation].
Given the malnutrition present in patients suffering from advanced hepatic illness, as well as the implications of this in the post-hepatic transplant period, a study was made of various biochemical parameters (prealbumin, retinol-bound protein, zinc, magnesium, cholesterol and amino acid pattern) as indicators of the nutritional condition of a series of 15 patients who underwent hepatic transplants and required total parenteral nutrition (TPN) during the first 10 post-transplant days. Before the transplants were carried out, all the patients studied showed a decrease in all evaluated parameters. Ten days after the transplant, and having been fed parenterally during this time, the different parameters corrected themselves, with the exception of cholesterol. TPN, administered with enrichment of branched amino acids by 35%, practically normalized the plasma amino acid pattern.
Adult↗
[The use of immunologic parameters to assess the effectiveness of parenteral nutrition. Preliminary study].
Malnutrition leads to cellular and humoral immunological response disorders. A study protocol on malnourished patients has been designed in order to assess immune response mechanisms that may be altered due to malnutrition and may or may not recover once normal metabolic conditions have been restored prior to starting the patient on parenteral feeding and control. The immune response was assessed especially regarding immunoglobulin, lymphocyte subsets and mitogen response levels. It is important to know the different malnutrition-related immunologic disorders, disorders secondary to diseases that hinder correct oral feeding, and immunologic tests may be used to assess nutritional parameters. The malnourished patients included in this trial has to be free of any other immunologic or neoplastic disease, and not receive immune response suppression therapy. The trial patients showed lower total and relative CD3 and CD4 lymphocyte values at the onset of the study, although the former lymphocyte subset recuperated sooner at the expense of increasing CD8 lymphocytes, while CD4 lymphocytes still remained low after 15 days of parenteral nutrition. Immunoglobulin levels remained within normal limits. The mitogen response capacity, which was sensibly low at the beginning, recuperated in 50% of the cases treated with parenteral nutrition. This parameters may be used as an index to assess the nutritional status of these patients. The cases studies allowed us to conclude that there was a decrease in CD4 cells and mitogen response in malnourished patients. After 15 days of parenteral nutrition, the cells did not recuperate but their function measured in terms of phytohemagglutinin, was normal in 50% of the cases.
Humans↗
[Epidermal growth factor: is its application in nutrition feasible?].
Epidermal growth factor (EGF) was isolated in 1969 by Stanley Cohen in the submaxillary gland of the rat, and its structure was described by Taylor and Cohen in 1972. EGF is a 53-residue polypeptide, weighing 6372 daltons. It is synthesized in a precursor form, as Prepro-EGF, and is secreted into the saliva, intestine and urine. The degradation of EGF takes place primarily in the liver and secondarily in the digestive tract and kidney. EGF is a powerful mitogen, acting upon several types of cells. The epidermal growth factor receptor (EGF-R) is a 170,000 dalton glycoprotein which binds equally to EGF and transforming growth factor alpha (TGF-alpha), a constituent closely homologous to EGF. Presently, published studies concerning the use of EGF in parenteral and enteral nutrition are limited to experimental animals, in which clear effects on cellular proliferation have been observed. It has an important function in the digestive tract, protecting the gastric mucosa from stress and necrotizing agents. Thus, it might be useful in a new nutritional strategies, serving to combine the clearly beneficial effects provided by protein intake (non amino acid with those of the intestinal trophic and growth factors, in both parenteral and enteral nutrition.
Drug Synergism↗
[Total abdominal irradiation. Choice of experimental dosage].
Radiation therapy induces morphological and functional changes in small intestine leading to nutrient malabsorption. The aim of this study was to determine the effect of total abdominal irradiation on body weight in rats. The study was performed in four groups of animals treated at increased levels of radiation: 400, 600, 800 and 1,000 cGy. The decrease in body weight observed was similar at the caloric and nitrogen intake and were more pronounced as the dose of radiation increased.
Animal Feed↗