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Biomedical subjects

M Farina

Publications and source records attributed to M Farina.

134 records · Page 8Linked to original sources
PubMedDate not supplied

[Extemporaneous examination of the sentinel lymph node in breast cancer: is the glass half full or half empty?].

Intra-operative examination of sentinel LN is controversial. Concordance with definitive exam of SLN in this series was 81%, though only 54% of positive cases were diagnosed. Micrometastases and ITC were usually lost intraoperatively, accounting for 14% of cases. Frozen section and touch prep of the SLN were approximately equivalent. The latter has the advantage of preserving tissue for step-analysis of SLN. The ultimate method of intraoperative analysis of SLN which can combine cost-effectiveness and accuracy needs to be determined.

Aged↗
PubMedDate not supplied

[Experience in prevention of risks caused by manual movement of patients in a health institution].

In its hospitals, the local Reggio Emilia Division of the National Health Service has introduced beds and stretchers with up-and-down movement systems, electrical lifters for patients, and highly mobile trained more than one thousand workers in the correct execution of maneuvers for moving patients manually platforms and litters for transferring patients from stretcher to bed. The Division has also. The risk evaluation models available in the literature have proved to be inadequate for instituting a program of improving service or for adequately supporting the doctor in charge. To overcome these limitations, a standard of risk evaluation called SpoSo ("Spostamenti Sollevamenti"--"Moving and Lifting") has been experimentally adopted.

Humans↗
PubMedDate not supplied

[Locally advanced and recurrent pelvic colorectal carcinoma: results of aggressive surgical treatment].

Pelvic exenteration has been described as a formidable procedure in cases of advanced or recurrent pelvic cancers for a variety of primary tumors, including colorectal, gynaecologic and urologic. We report our 14-year experience in a community hospital with 37 cases who underwent pelvic exenteration for recurrent (n = 15) or locally advanced (n = 22) colorectal cancers. At a median follow-up of 36 months, the median survival was 24 and 36 months, respectively, and the 5-year actuarial survival was 18% and 44%.

Adult↗
PubMedDate not supplied

[Hormone-dependence and C-ERBB2: relationship between estrogen receptor expression, estrogen-regulated proteins, and C-ERBB2 in breast carcinoma].

We reviewed 1491 consecutive cases of operated breast cancer between 1999-2004, and found that hormone-dependence, particularly if evaluated with functional markers of the estrogen receptor (estrogen regulated proteins, ERP), is inversely proportional to antigen neu expression. Our data confirms that ERP can give additional information on the probability of response to hormonal therapy.

Breast Neoplasms↗
PubMedDate not supplied

[Predictive variables of lymphatic metastasis in breast carcinoma with a diameter below 2 cm].

The axillary lymph node status of patients with newly diagnosed breast cancer remains the most important prognostic information available at the moment. However, only a minority of patients presents with such node metastases at diagnoses. We reviewed our database and studied 500 consecutive patients with early breast cancer, and found that age inferior to 50 years, high grade, diameter superior to 1 cm, elevated Ki-67, and expression of oncogene p-53 are all factors associated with lymph node metastases.

Breast Neoplasms↗
PubMedDate not supplied

[Towards the standardization of sentinel lymph node analysis in women with breast cancer].

Sentinel lymph node biopsy allows enhanced pathology through serial sections and immunohistochemical analysis of the retrieved node, with detection of micrometastases and isolated tumor cells not otherwise recognized. We present our experience with a simple, effective, pathology protocol requiring six couples of sections at three different sentinel lymph node levels. Additional micrometastases or ITC were diagnosed in 51/416 patients (14.6%).

Breast Neoplasms↗
PubMedDate not supplied

[Does incidence of sentinel lymph node metastasis increase after diagnostic manipulation in women with breast cancer?].

503 patients were retrospectively evaluated to assess whether a previous needle or core biopsy, or surgical surgical excision of the primary tumor are associated with passive dislodgment of tumor cells in the sentinel lymph node, as reported in recent publications. We could not identify any increased incidence of sentinel lymph node micrometastases or isolated tumor cells after diagnostic manipulation of the primary tumor.

Breast Neoplasms↗