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Biomedical subjects

M F Woodruff

Publications and source records attributed to M F Woodruff.

At least 55 records · Page 3Linked to original sources
PubMed1971

Synergistic inhibition of mammary carcinoma transplants in A-strain mice by antitumour globulin and C. parvum.

It has been confirmed that the growth of intrastrain transplants of a mammary carcinoma in A/HeJ mice is inhibited to a moderate extent by giving the prospective recipient an intravenous injection of killed C. parvum 2 days before tumour inoculation. Intraperitoneal injection of C. parvum gave similar results but subcutaneous injection was less effective. Incubation of tumour cells with heterospecific antitumour globulin (ATG) in the absence of complement before inoculation sometimes but not always resulted in moderate inhibition of tumour growth. When pre-incubation of tumour cells with ATG and treatment of the host with C. parvum were combined the inhibitory effect was much greater than that produced by either procedure alone, and was roughly equivalent to reducing the dose of viable cells in control animals by a factor of 100. Since A/HeJ mice lack the fifth component of complement (C'5) it was expected that this serum would be ineffective as a source of C' in in vitro cytotoxic tests but effective in opsonisation tests. This has been confirmed. The possible significance of this finding in relation to the synergistic effect of ATG and C. parvum is discussed.

Animals↗
PubMed1968

Paraquat poisoning--lung transplantation.

A 15-year-old boy ingested a mouthful of paraquat and developed severe respiratory distress. Treatment included the transplantation of one lung, but subsequently changes developed in the graft which are thought to have been due to paraquat, and the patient died two weeks after the operationThe dangers of keeping poisonous substances in incorrectly labelled bottles has once again been demonstrated, while the pattern of paraquat poisoning, especially the development of proliferative alveolitis and terminal bronchiolitis, is confirmed.Immediate forced diuresis followed by haemodialysis is necessary to remove paraquat, thereby perhaps avoiding initiation of the changes in the lungs. The technical feasibility of human lung transplantation has again been demonstrated. It has also been shown that infection does not necessarily pose an insuperable problem, at any rate if, as in the case described, there was no preoperative pulmonary infection in either recipient or donor.

Adolescent↗