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Biomedical subjects

M F Spittle

Publications and source records attributed to M F Spittle.

85 records · Page 5Linked to original sources
PubMed1973

Hodgkin's disease. A clinico-pathological study of 250 cases with a 5-year follow-up.

Two hundred and fifty cases of histologically proven Hodgkin's disease have been reviewed. These cases were classified according to the Rye Conference histological classification (Lukes et al., 1966a) and according to the Cross classification (Cross, 1969). Overall, both classifications were reasonably effective in predicting prognosis but that of Cross with its seven sub-groups proved more difficult to use than the simpler Rye classification. In all cases the follow-up period exceeded 5 years. A study was made of the influence of clinical symptoms on survival with particular reference to night sweats, fever, pruritus, anorexia, lassitude, weight loss, haematological abnormalities and splenic enlargement. The presence of these abnormalities adversely affected prognosis. The spread of the disease from one group of nodes to the next was also documented. Considering all cases the 5-year survival was 54%. The 5-year survivals according to histological type were: lymphocytic predominance 69%, nodular sclerosis 57%, mixed cellularity 41%, lymphocytic depletion 40%. The 10-year survival was 23% which, when corrected by the actuarial method (Berkson and Gage, 1950), rose to 36%. The importance of symptomatology as well as histological grading in the prognosis of Hodgkin's disease is confirmed.

Adolescent↗
PubMed1970

Liposarcoma. A review of 60 cases.

Sixty cases of liposarcoma are presented. The pathological appearances, clinical features and methods of treatment are described. The overall 5-year survival was 64%.

Adolescent↗
PubMedDate not supplied

Primary breast cancer. Complications of axillary management.

The complications following surgery and postoperative radiation therapy in the management of the axilla in 187 patients with primary breast cancer treated between 1978 and 1982 have been studied. Although no difference in complication rate could be detected between the three different postoperative radiation schedules utilised there was a strong and positive correlation between complication rate and increasing extent of surgical intervention. When the groups were sub-divided according to the extent of surgery performed, no differences in regional recurrence rates were observed but complication rates (defined as significant lymphoedema of the arm and/or restriction of shoulder movements) were significantly different (p less than 0.001) at 30 months between those who had no surgical intervention (25%), those who had had 'sampling' performed (50%) and those who had had formal dissection performed (84%).

Arm↗
PubMedDate not supplied

AIDS-related lymphoma: an emerging epidemic.

Acquired immunodeficiency syndrome-related lymphoma is a serious opportunistic complication of human immunodeficiency virus (HIV) infection which is predicted to increase in frequency over the next few years. The presence of this malignant process in HIV-related individuals, who are already immunocompromised, constitutes a major cause of morbidity and mortality, determining both therapy and prognosis.

Acquired Immunodeficiency Syndrome↗