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Biomedical subjects

M F Sorrell

Publications and source records attributed to M F Sorrell.

At least 163 records · Page 9Linked to original sources
PubMed1976

Effects of a single intoxicating dose of ethanol on the vitamin profile of organelles in rat liver and brain.

The effects of a single, oral, intoxicating dose of ethanol (EtOH, 9 g/kg body weight) on the distribution of water- and fat-soluble vitamins in various subcellular fractions of eight rat livers and eight rat brains was surveyed. Results were compared to eight other rats receiving a similar dose of saline (controls). Both organs showed redistribution of vitamins among the various organelles after EtOH was given. In saline-treated animals the nucleus and cytosol of the liver contained the highest proportion of all vitamins and the microsomes and lysosomes contained the least. As compared to controls, EtHO ingestion generally caused the mitochondria and microsomes to accumulate vitamins, while vitamins in the lysosomes were decreased. A different pattern was seen in the brain after EtOH administration. Except for thiamin and niacin, the whole brain vitamins were higher than those in controls; they were primarily concentrated in the brain nucleus and mitochondria. It was concluded that changes in the organelle vitamin content of the liver were the result of EtOH injury. The simultaneous attempt to repair the injury was manifested by the by the sequestration of vitamins in the organelles of EtOH-treated animals as compared to controls.

Alcoholic Intoxication↗
PubMed1976

Altered elimination of antipyrine in patients with acute viral hepatitis.

The plasma half-life and clearance of antipyrine was investigated in patients during the acute phase and again during the recovery phase of viral hepatitis. Each patient served as his own control, thereby eliminating genetic factors and minimising environmental factors that cause large interindividual variations in antipyrine elimination rates. Liver function tests, antipyrine, half-life, plasma clearance, and the apparent volume of distribution were determined in the acute and recovery period. It was found that the appaarent volume of distribution of antipyrine did not change in five of six patients as they recovered. Five of the six patients showed prolonged plasma half-lives and decreased plasma clearance of the drug at the time of acute illness and these parameters reached normal values during recovery. The plasma half-life and clearance of the drug did not correlate with biochemical indices of liver function in the recovery phase. This demonstration supports the concept that drug metabolism is frequently impaired in liver disease.

Adult↗
PubMed1976

Hodgkin's disease of the rectum.

In a rare case of Hodgkin's disease of the rectum, plain films of the abdomen revealed splenomegaly, and fluoroscopy demonstrated anterior displacement of the stomach and duodenum, believed to be secondary to enlarged lymph nodes. Fluoroscopic examination of the colon showed a large, annular constricting lesion with nodular-appearing mucosa.

Adult↗
PubMed1975

Inability of selenium to affect creatine metabolism in rat muscle.

1. Two groups of adult rats were placed in a metal-free environment and pair-fed with selenium-supplemented and Se-deficient diets. 2. After 5 months the animals were killed and skeletal muscle concentrations of creatine, creating phosphate, ATP, protein and Se were determined. 3. Se deficiency was indicated by the low Se content of the skeletal muscle from the deficient animals, but no changes were found in the amounts of the other components. 4. These results suggest that Se may not be involved in creatine metabolism and that Se deficiency may not be concerned independently in the development of nutritional dystrophy, where changes are found in the levels of protein, creatine, creatine phosphate and ATP.

Adenosine Triphosphate↗