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Biomedical subjects

M F Poirier-Littre

Publications and source records attributed to M F Poirier-Littre.

8 recordsLinked to original sources
PubMed1997

Amisulpride versus placebo in the medium-term treatment of the negative symptoms of schizophrenia.

BACKGROUND: Amisulpride is a substituted benzamide with high selectivity for dopamine D2 and D3 receptors. The purpose of the study was to evaluate the effect of 100 mg amisulpride in patients with predominantly negative symptoms of schizophrenia. METHOD: This was a multi-centre, randomised, parallel-group, double-blind study. Patients received either amisulpride (100 mg/day) or placebo over a six-month treatment period. RESULTS: A total of 141 patients were included, 69 received amisulpride, 72 placebo. Fifty-eight patients (41%) had received neuroleptic treatment prior to inclusion. The percentage of amisulpride patients completing the study (55%) was significantly higher than that with placebo (32%), and drop-out rates due to lack of efficacy were 27% with amisulpride and 47% with placebo. All efficacy assessments were statistically in favour of amisulpride compared with placebo. The overall incidence of extrapyramidal symptoms was comparable in both groups; only five patients started anti-Parkinsonian treatment during the study (one in the placebo and four in the amisulpride group). CONCLUSION: Amisulpride is effective in the medium-term treatment schizophrenic patients with predominantly negative symptoms.

Adult↗
PubMed1995

Factorial structure of the 17-item Hamilton Depression Rating Scale.

The Hamilton Depression Rating Scale was applied to 60 depressed inpatients diagnosed using the Composite International Diagnostic Interview. The information to rate the scale was obtained with a semistructured interview to standardize the scale administration method. Items were factorized using principal components analysis with Varimax rotation. Three factors were obtained with the simulation method, accounting for 47% of variance. The first includes the core symptoms of depression. The symptoms of patients having an isolated mood disorder were compared with those having comorbidity with other diagnoses. The comorbidity did not affect the first factor but modified the second factor (anxiety) and the third factor (insomnia).

Adult↗
PubMed1986

Decrease in plasma levels of 3,4-dihydroxyphenylethyleneglycol in major depression.

Plasma levels of free and sulfoconjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were measured in a group of 45 hospitalized patients presenting a major depression and a group of 45 healthy subjects, matched for sex and age. Compared to healthy subjects, depressed patients had significantly lower plasma levels of free and sulfoconjugated DOPEG. The ratio of free over conjugated DOPEG was not statistically different in the two groups. The reduction of plasma DOPEG levels in the depressed patients did not appear to be related to the duration of drug-free period and was similar in males and females. There was no statistically significant correlation between plasma DOPEG levels and total score on the Hamilton Rating Scale for Depression. Finally, plasma DOPEG levels did not differ in unior bipolar patients. The present data provides further evidence for a reduced CNS noradrenergic transmission in major depression.

Adolescent↗
PubMed1982

[The value of the measurement of intra-erythrocytic lithium in the bio-clinical surveillance of lithium therapy (author's transl)].

THe correlation between red cell lithium concentration and signs of neurotoxicity have been reported in the literature by a great majority of authors. A deficiency in the lithium-sodium counter-transport mechanism may be responsible. Measurement of blood lithium levels only is not always sufficient to identify in the laboratory patients showing signs of intolerance. The three cases reported here indicate the limitations of the measurement of plasma lithium levels and the perfect correlation between neurological signs and erythrocyte levels. In vitro studies of transmembrane ion exchanges should make it possible to undertake an investigation before starting treatment in order to identify the risks of cellular toxicity.

Adult↗
PubMed1980

Influence of route of administration on haloperidol plasma levels in psychotic patients.

Haloperidol plasma concentrations were determined in psychotic patients to whom the drug was given by three different routes of administration (i. v. perfusion, intramuscularly and orally). When measured 15 hours after the last administration, a significant difference (p < 0,001) was found in the steady state plasma concentration between the oral and the i.m. route. The values were higher after intramuscular administration and were subject to less interindividual fluctuation than after the oral. The reduction in plasma levels after oral administration in respect to i.m. were in accordance with the bioavailability of haloperidol. The opportunity of switching from oral to intramuscular treatment is discussed.

Administration, Oral↗