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Biomedical subjects

M F Oliver

Publications and source records attributed to M F Oliver.

At least 217 records · Page 12Linked to original sources
PubMed1971

Free fatty acids during acute myocardial infarction.

Free fatty acids (FFA) are elevated in plasma soon after the onset of symptoms associated with developing myocardial infarction. Levels above 1200 mu Eq./L. are associated with a significantly increased incidence of serious ventricular arrhythmias, heart block and sudden death. Evidence is presented from experimental myocardial infarction in dogs to show that high levels of FFA can themselves cause arrhythmia, although catecholamines are mainly responsible for the mobilization of FFA during clinical episodes of acute myocardial ischemia. It is postulated that high concentrations of FFA irrespective of the mode of elevation have a deleterious effect on the function of the heart during hypoxia. These observations offer a new therapeutic approach to the management of arrhythmias and of acute myocardial infarction. Attention should be directed to blocking FFA release from adipose tissue and to providing the hypoxic myocardial cells with a concentration of glucose which will provide adequate substrate for all energy requirements of the heart.

Animals↗
PubMed1970

Oral contraceptives and myocardial infarction.

During 1965-9 22 women aged 41 years or less have been seen with myocardial infarction. Eleven had been taking oral contraceptives. This prevalence of oral contraception (50%) is appreciably greater than that estimated for women of the same age in the general population.Nine of these 11 women had an independent increased risk of developing ischaemic heart disease because of hyperlipidaemia, hypertension, or excessive cigarette smoking. Ten of the 11 not taking an oral contraceptive also had a readily identifiable predisposing factor. None of the 22 showed carbohydrate intolerance. The similarity of the two groups is the striking finding. Details of 15 women of comparable age seen during 1960-4 before oral contraceptives were widely used are also presented, and they had similar characteristics.Oral contraceptives do not appear on their own to increase the risk of developing myocardial infarction, but they may do so in women otherwise prone to ischaemic heart disease. Suggestions are made for the identification of these women.

Adult↗
PubMed1970

Clofibrate, serum enzymes, and muscle pain.

Serum creatine kinas (C.K.), aspartate amino-transferase (G.O.T.), and alkaline phosphatase (A.P.) activities were measured in 211 men with serum cholesterol concentrations in the upper one-third of the normal distribution. Of these, 110 were receiving clofibrate and 101 were given identical capsules containing olive oil. These investigations were also carried out on 85 healthy men with low serum cholesterol levels not receiving clofibrate.No differences were observed in C.K. and G.O.T. activities between any of these groups; A.P. was significantly lower in the clofibrate-treated group. No significant alterations in C.K. occurred during serial observations made in 15 patients with ischaemic heart disease over a period of five months. No instance of myalgia or muscle stiffness was recorded in 452 men who had received clofibrate for one year.It is concluded that raised C.K. and G.O.T. concentrations and the occurrence of myalgia are uncommon accompaniments of clofibrate treatment.

Adult↗