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Biomedical subjects

M F Mozes

Publications and source records attributed to M F Mozes.

68 records · Page 4Linked to original sources
PubMed1976

Orthotopic renal homotransplantation in a patient with thrombosis of the inferior vena cava.

Complete thrombosis of the infrarenal vena cava and the entire iliac venous system is a unique circumstance in a candidate for renal allotransplantation. This condition was created in a patient by the previous use of an inferior vena cava clip. The patient received a kidney transplant in the orthotopic intra-abdominal position, using his own renal vein for renovenous anastomosis. The usual method of urinary drainage was also modified. This approach to transplantation should be considered in the presence of partial clotting or occlusion in the distal vena cava or iliac venous system.

Adult↗
PubMed1976

Immunopathological studies of the ruptured human renal allograft.

The immunopathology of five cases of spontaneous allograft rupture has been studied. All kidneys were edematous on exploration and routine histological sections showed interstitial edema and mononuclear cell infiltration characteristic of acute rejection. Immunofluorescence revealed, at most, scattered vascular deposition of IgM and mild mesangial C3 deposition. These findings are compared with findings in normal kidneys and kidneys which had been hyperacutely rejected. The normal kidney showed focal afferent arteriolar and proximal mesangial stalk deposition of C3 without IgM. The kidneys of patients with hyperacute rejection showed brilliant staining for fibrin and IgM in all arterial and arteriolar walls with lesser amounts of C3 and IgG; IgM and C3 were prominent in the glomerulus. These findings suggest that mechanisms other than circulating preformed antibodies are responsible for the pathogenesis of spontaneous allograft rupture.

Fluorescent Antibody Technique↗
PubMedDate not supplied

Use of perfusion parameters in predicting outcomes of machine-preserved kidneys.

Perfusion parameters (PP) and early transplant outcome data from 332 consecutive ECD type kidneys machine preserved on the Waters RM-3 apparatus were reviewed and analyzed to examine the validity of using suboptimal PPs (renal resistance of .41-.60) as a criterion for discarding kidneys. Overall discard rate was 23.5%, with 55% of these having "poor" PP as part of reason for discard. PP analysis after 4 hours on the RM-3 is presented. This encompasses 280 kidneys with renal resistance </= .60. Sixty-six kidneys were discarded (23.5%). Of the 214 transplanted kidneys, 146 had immediate function (IF; 68%), 63 had delayed function (DGF; 29%), and 5 never functioned (PNF; 2%). Of the 30 transplanted kidneys with renal resistance .40 to .60, 16 (53%) had IF versus 58% in kidneys with renal resistance </= .40 (P = .125). Two of the five PNF kidney had renal resistance > .40. The PP-related discard rate in the renal resistance .41 to .60 kidneys was 51% versus 17% in the renal resistance </= .40 (P </= .01). Based on our observations kidneys with renal resistance </= .60 should not be discarded strictly based on "suboptimal perfusion parameters." This presents an opportunity for a decrease in discard rates of ECD kidneys.

Humans↗
PubMedDate not supplied

Gastrocnemius compression sign in arterial insufficiency of the leg.

A simple bedside diagnostic maneuver, consisting of a bimanual compression of the gastrocnemius muscle and its use in the assessment of lower limb ischemia, are described. The compression evokes a pain response in the ischemic muscles and, when positive, is strongly suggestive of vascular insufficiency and, when absent, suggests a nonvascular etiology. Thus, the test is useful for the differentiation of vascular from nonvascular leg pain and is recommended as a diagnostic screening maneuver. Further diagnosis requires appropriate clinical judgment and the use of confirmatory tests.

Humans↗