Biomedical subjects

M F Lerat

Publications and source records attributed to M F Lerat.

At least 37 records · Page 2Linked to original sources

PubMed1981

[Electromicroscopy of the nerve structures in human myometrium at term (author's transl)].

The authors describe the ultrastructure of myelinated and nonmyelinated nerve fibres as seen in human myometrium at the end of pregnancy. The nerve ending looks degenerate and is found in close contact with a structure that is probably muscular. This ultrastructural appearance corresponds to the quantitative levels of noradrenaline found in the tissues at the end of pregnancy which show that the uterus becomes depleted of catecholamines.

Female↗

PubMed1980

[Hydramnios as evidence of Steinert's congenital myotonic distrophy (author's transl)].

The authors describe a case of Steinert's disease. It was tracked down because of three anomalies of pregnancy: a lessening in active movements of the fetus, breech presentation and hydramnios, and it was diagnosed by neurological and electromyography of the mother. The existence of hydramnios should make it possible to avoid maternal trauma during the delivery, knowing that the child will be born with a very severe form of the illness, which is likely to be lethal. Those few cases that survive are severely mentally handicapped.

Adult↗

PubMed1980

[Late alerting signs of abnormalities during pregnancy].

Explore the source record for details and available documents.

Amniotic Fluid↗

PubMed1979

[Plasma hormonal pattern of the late diabetic pregnancy (author's transl)].

Plasma estradiol, estriol, progesterone, H.C.S. and cortisol were measured (RIA methods) every two days, in 20 diabetic pregnancies (classes B, C or D of White), between the 33th week and the delivery, and were compared with normal pregnancies. Estriol was always normal, and progesterone values were at the upper limit of the normal range; estradiol, H.C.S. and cortisol were normal or elevated, with mean values significantly higher than controls. E2 and/or progesterone dramatically decreased in 5 cases before birth, just as the urinary measurements. In this study, the insulin requirements were not correlated with these plasma hormone values. Besides pathogenic hypothesis )glycemic control of H.C.S. and cortisol--abnormalities of metabolic pathways of estrogens ?), this work informs the inferred hormonal deficiency in diabetic placenta. Also, it is unable to determine the practical usefulness of these plasma measurements in the management of diabetic pregnancy.

Adult↗

PubMed1978

[The onset of labour. A reminder of its physiology (author's transl)].

Until recently the onset of labour was considered to be due to changes in maternal hormone levels which were represented by a drop in the progesterone and a rise in the oxytocin levels. Recent work has shown that onset of labour is associated with several phenomena which take place parallel to one another, and they are immunological, haemodynamic, biochemical, mechanical, psychological and hormonal. The last of these are far and away the most important and have three sources: a placental source; a maternal source of sex steroids, oxytocin and prostaglandins and; of fetal origin, adrenal and posterior pituitary hormones. It seems that the prostaglandins and the maturation of the fetal brain are at present considered to be all-important. Better knowledge of the physiology of the onset of labour has led to greater success in pharmaco-dynamically induced labour, but this is not yet truly physiological. Therefore except in cases of pathology it does not seem right to undertake the risks of inducing labour more or less systematically.

Adrenal Cortex Hormones↗

PubMed1975

[Examination of the uterine cervix using the scanning electron microscope].

Scanning by electron microscopy of the cervix of the uterus allows us to study the various aspects, both normal and pathological, as well as the architecture of sections of the organ. All the same, as in all practical examinations carried out using scanning we have to beware of pictures that are but artefacts due to the method of preparation. The views obtained from a normal cervix of from pathological cervices show very different aspects. In the normal cervix the surfaces are more or less smooth and the architecture of the deeper levels shows a thick and regular texture. Infectious lesions of the outer aspect of the cervix show punched-out patterns, like craters, which penetrate more or less deeply into the sub-epithelial plane. While cervical dysplasia shows little except perhaps a more or less bossed-up epithelial surface, cancer of the cervix on the other hand shows a pavement pattern which is irregular. The pavements are formed by buds which are separated by faults which are more or less deep. In section the structures show a degree of disorientation in the texture. After treatment with radium the appearance is rather like ground glass of spiders webs and the architecture of the structures seems to be pock-marked and chaotic.

Cervix Uteri↗

PubMed1973