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Biomedical subjects

M F Leonard

Publications and source records attributed to M F Leonard.

15 recordsLinked to original sources
PubMed1987

Inhibitory effect of Azone (1-dodecylazacycloheptan-2-one) on herpes simplex viruses. In vivo and in vitro studies.

Enhanced activity of antiviral agents, when mixed with a penetration enhancer like Azone (1-dodecylazacycloheptan-2-one) in topical preparations, is well-recognized. These studies were undertaken to investigate whether Azone, per se, has any activity against herpes simplex (HSV) type 1 and type 2 viruses. When HSV-1 and HSV-2 were mixed with 5, 10 and 20% Azone, there was a 1-4.5 log10 decrease in virus titers. The efficacy of 5 and 10% Azone applied topically was evaluated during the treatment of HSV-1 cutaneous infections in guinea pigs. HSV-1 infection was produced by intradermally inoculating guinea pigs with 10(7.7) HSV-1/ml. The mean number of lesions per site was reduced by more than 50% in Azone-treated sites as compared to no treatment (control) sites (p less than 0.01). Similarly, the surface area of each lesion in the Azone-treated sites was only 40% of that seen in control sites (p less than 0.001). More than 80% of the lesions on Azone-treated sites healed by day 4 as compared to only 3% on control sites (p less than 0.001). These data indicate that Azone, a lipophilic chemical, may have antiviral properties when used topically.

Animals↗
PubMed1982

A prospective study of development of children with sex chromosome anomalies - New Haven study III. The middle years.

This is the third report of a prospective study of children with sex chromosome anomalies identified at birth in New Haven, Connecticut. Previous reports in 1974 [1] and 1979 [2] summarized data from the first 2 1/2 years and the first 9 years of the children's lives, respectively. The present report will focus on progress and evaluations in the years 9-13, concluding with an Appendix of Case Summaries which provide an overview of 6 of the cases. Accumulation of data from such children is increasingly important to assist in genetic counseling. Because of the rarity of sex chromosome aneuploidy (about 1 in 400 newborns), no one center sees enough of these children to feel confident about the validity of results. However, the periodic meeting, sharing of data, and joint publication of results by investigators in several centers, made possible by the March of Dimes provide large enough numbers of children with each karyotype for valid conclusions about range of expected growth and development through the preadolescent years. Therefore, this report is published together with those from other centers, as in the 1979 report [2].

Achievement↗