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Biomedical subjects

M F Greaves

Publications and source records attributed to M F Greaves.

At least 235 records · Page 13Linked to original sources
PubMed1975

A surface antigen marker for human monocytes.

Antisera have been raised in rabbits aginst human peritoneal macrophages. After absorption with tonsil cells the sera reacted, by direct and indirect immunfluorescence, with phagocytic mononuclear cells from a variety of tissues and, in addition, stained a small population of nonphagocytic non-T, non-B mononuclear cells present in blood, spleen, and marrow but absent or very rare in tonsil and thymus. The antisera may define a human monocyte-macrophage cell surface differentiation antigen (HuMA) and can be used to deplete or enrich reactive cell population.

Animals↗
PubMed1975

Identification of cells with monocyte markers in panhypogammaglobulinaemia.

Nonphagocytic cells bearing receptors for complement and IgGFc in blood samples from four boys with panhypogammaglobulinaemia who lacked B lymphocytes were positively stained for human macrophage antigen (HuMA) and intracellular peroxidase. Similar non-T, non-B cells were found in adult blood preparations but in lower numbers than in the four boys above and in two of three other boys with various immunodeficiencies. Because of their monocyte characteristics, it is improbable that these cells are B-lymphocyte precursors; this is consistent with our view that there is a central failure of B-cell induction in boys with panhypogammaglobulinaemia who lack lymphocytes with surface immunoglobulin.

Adolescent↗