Biomedical subjects

M Evers

Publications and source records attributed to M Evers.

21 records · Page 2Linked to original sources

PubMed1988

Effect of a segregated-care system on patients' length of stay in intensive care.

The Internal Medicine Residency Program of the Raritan Bay Medical Center's Perth Amboy Division was changed in July 1987 from a full continuity-of-care system to a unit-isolation one. The authors compared patients' data from the first two months of the academic years 1986-87 and 1987-88 and were unable to observe any impact of the change on length of stay in intensive care. However, informal interviews with the house staff members indicated that the change had a positive impact on their education, because of their closer observation of the pathophysiology of individual disease states and greater enjoyment of the time spent in critical care.

Adolescent↗

PubMedDate not supplied

Evaluation of advanced cardiac life support in a community teaching hospital by use of actual cardiac arrests.

OBJECTIVE: To determine the retention of Advanced Cardiac Life Support training of internal medicine residents as a function of the time since successfully completing ACLS training. DESIGN: Prospective, consecutive sample of patients who underwent a cardiopulmonary resuscitation effort directed by physicians who successfully completed ACLS. SETTING: Eastern community teaching hospital. PATIENTS: 180 consecutive patients over the age of 18 years who sustained a cardiopulmonary arrest and whose resuscitation efforts were directed by physicians who successfully completed ACLS. Forty-five additional resuscitative efforts hospital wide were led by non-ACLS-trained physicians during the study period. OUTCOME MEASURES: Correctness of the diagnosis of rhythms and treatment of the rhythms diagnosed were assessed, as per ACLS protocols in effect at the time of the study, in 1991. INTERVENTION: None. RESULTS: Chi-squares were used for analysis. Seventy-six of the resuscitative efforts were run by medical residents with a 13.2% error rate. The error rate in the first 6 months after ACLS completion among residents was 5.1%, as compared with 21.6% in the next 6 months (p = 0.033), with no impact on actual survival rate. During the study period, error rates among other groups were 8.8% in Emergency Department physicians and 17.8% among non-ACLS-trained physicians. CONCLUSIONS: The error rate found was lower than in previous studies evaluating retention of ACLS education. It is important to have regular updates in ACLS to ensure proper protocol use.

Adult↗

PubMedDate not supplied

Microsomal metabolism of 2-(methylseleno) benzanilide.

2-(Methylseleno)benzanilide, a metabolite of ebselen, was oxidatively demethylated by rat liver microsomes to regenerate the parent compound, ebselen. The rate of this novel reaction exceeds that of ring hydroxylation, and it was inhibitable with metyrapone. The sulfur analogue, 2-(methylthio)benzanilide, was oxidized to the corresponding sulfoxide. The regeneration of ebselen from 2-(methylseleno)benzalide is suggested to result from an intermediate selenoxide and hydrolysis with formation of methanol, since only very small amounts of labeled formaldehyde were detected in incubations using 2-[(14C)methylseleno]benzanilide. In an analogous reaction, 2-(benzylseleno)benzaldehyde yielded ebselen upon oxidation with hydrogen peroxide and, as detected by gas-liquid chromatography, benzyl alcohol.

Anilides↗