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Biomedical subjects

M Ertürk

Publications and source records attributed to M Ertürk.

9 recordsLinked to original sources
PubMed2001

Management of military vascular injuries.

BACKGROUND: Vascular injuries caused by high-velocity military missiles during war present large and extensive defects of tissues and bones, are often associated with other injuries. In this study we will discuss the surgical strategy and results of military vascular injuries. METHODS: A retrospective review of records of 63 patients treated between January 1995 and December 1999 was undertaken. RESULTS: The mean age of the wounded was 22.3 years (range, 20 to 37 years). The mean time for evacuation from the place of injury to the hospital was 2.3 hours (range, 15 min to 10 hrs). There were 58 (76.3%) arterial and 18 (23.7) venous injuries. Vascular injuries concomitant with 28 (36.9%) bone fractures, six (7.9%) nerve injuries, nine (11.8%) hemopneumothorax and one (1.3%) abdominal injuries. The treatment of the injured arteries were 39 (51.3%) saphenous vein interposition grafting, 13 (17.1%) end to end anastomosis, 12 (15.7%) primary suture, seven (9.2%) synthetic graft replacement. Three patients (3.9%) died because of hypovolemic shock. Five patients underwent amputation (6.6%) and fasciotomy was performed after vascular repair in 11 cases (14.5%). CONCLUSIONS: At the military vascular injuries, the right timing, and also prompt treatment save the life of the patients and give better qualified living to the patient.

Adult↗
PubMed1997

Evaluation of the Amor and ESSG classification criteria for spondylarthropathies in a Turkish population.

This study evaluated the Amor and European Spondylarthropathy Study Group (ESSG) classification criteria for spondyloarthropathies in Turkish patients seen from October 1990 to August 1993 at the Physical Medicine and Rehabilitation Department of the GATA Haydarpasa Training Hospital. The Amor and ESSG criteria were evaluated in 157 patients with spondylarthropathies and in 124 controls with a variety of other rheumatic diseases. The sensitivity, specificity, positive predictive value, and negative predictive value of each criteria set were calculated, as well as the sensitivity and specificity of each of the 24 criteria used in these sets. For Amor's criteria, sensitivity was 88.5%, specificity was 91.9%, positive predictive value was 93.3% and negative predictive value was 86.4%. For the ESSG criteria, sensitivity was 86.6%, specificity was 91.1%, positive predictive value was 92.5% and negative predictive value was 84.3%. No significant differences were found between the two criteria sets. Our data show that the Amor and ESSG criteria are of similar value for the classification of spondylarthropathies and are comparable in terms of sensitivity and specificity. They also demonstrate the need for monitoring patients with equivocal clinical patterns using both sets of criteria as tools that complement each other.

Adolescent↗
PubMed1996

An anatomical study of the sigmoid sulcus and related structures.

Variations in the shape and size of the sigmoid sulcus were investigated in 561 temporal bones (438 isolated temporal bones, 49 skull bases and 25 half skull bases) and measurements of related structures were made. Right-left differences were analysed. The sigmoid sulcus was significantly wider (12 mm) and longer (38 mm) in the skull bases, while no differences were observed in the isolated temporal bones. The distance from the most prominent point of the mastoid process to the Frankfort horizontal plane (FHP) was 33 mm; no right-left difference was found. The distance from the genu of the sigmoid sulcus to the external acoustic meatus was 24.06 mm on the right side and 24.74 mm on the left side and this difference is significant, being considerably longer on the left side. The jugular foramen diameter was 7.8 mm; no right-left difference was observed. The relationship of the mastoid air cells to the sulcus was analysed and air cells were found just behind the sulcus in 66% and behind and posterior to the sulcus in 5% of temporal bones.

Cranial Sinuses↗
PubMed1989

Effect of influenza A on phagocytic cell function.

The effect of various strains of influenza virus on polymorphonuclear leucocyte (PMNL) function were studied by chemiluminescence (CL) and bacterial killing assays. All virus strains induced PMNL CL and peak CL correlated with haemagglutination (HA) but not neuraminidase (NA) activity of virus pools. Heat-treatment of virus pools generally had little effect on HA activity or ability to generate a PMN CL response but almost completely destroyed NA activity. Exposure of PMNL to each of the six virus strains resulted in loss of surface-associated sialic acid and a marked depression in both zymosan-induced PMNL CL and PMNL bactericidal capacity. However, there was no correlation between the degree of PMNL functional impairment and virus NA activity and, furthermore, heat treatment of virus pools removed NA activity but generally had little effect on their ability to reduce PMNL function. NA does not appear to play a primary role in impairment of PMNL function by influenza virus.

Adult↗
PubMed1989

Protection and serum antibody responses in guinea-pigs and mice immunized with HSV-1 antigen preparations obtained using different detergents.

Guinea-pigs immunized with a zwitterionic detergent-extracted HSV-1 antigen preparation responded with EIA and NT serum antibody titres that were significantly greater than those elicited by a non-ionic detergent-extracted antigen preparation inoculated using a similar dosage schedule. Following intravaginal challenge of the guinea-pigs with HSV-2 (strain SH/B), there was no statistically significant difference in the protection afforded to these animals by the two antigen preparations, although the results indicated the zwitterionic detergent-extracted HSV-1 antigen preparation to be slightly superior in this respect. In mice, the zwitterionic detergent-extracted HSV-1 antigen preparation elicited an EIA antibody response and partial protection against homologous virus challenge. The relevance of these animal models to determination of immunogenicity and efficacy of HSV vaccines prepared for use in man, and the reasons for the differences in immunogenicity of these HSV-1 antigen preparations in guinea-pigs, are discussed.

Animals↗
PubMed1989

Antibody responses and protection in mice immunized with herpes simplex virus type 1 antigen immune-stimulating complex preparations.

The formation of immune-stimulating complexes (iscoms) obtained by mixing the glycoside Quil A with an antigen preparation derived from herpes simplex virus type 1 (HSV-1)-infected cell cultures using a zwitterionic detergent is described. The HSV-1 antigen preparation incorporated into iscoms elicited significantly greater antibody responses in mice than the same preparation administered together with aluminium hydroxide gel, and provided complete protection against HSV-1 or HSV-2 lethal, systemic challenge infection in animals given a single dose containing 5 micrograms of protein. The HSV-1 iscom preparation also provided significant protection in mice against local reactions following challenge with HSV-1 by skin scarification.

Adjuvants, Immunologic↗
PubMedDate not supplied

Prostaglandin-independent decrease of sheep ureter contractility induced by bradykinin.

The mechanisms that mediate the actions of bradykinin on ureteral motility are poorly defined and mediation via prostaglandins has not been examined. Therefore, the effects of bradykinin on contractility and the possible mediator role of prostaglandins have been investigated in sheep ureter. At the concentrations of 10(-8), 10(-7) and 10(-6) M, bradykinin elicited marked reductions in contractile force. When ureteral strips were treated separately with 10(-6) M indomethacin, 2 x 10(-6) M sodium salicylate and 10(-5) M aspirin, each drug produced a significant decrease in contractile force. In strips in which prostaglandin synthesis was inhibited by the above concentrations of indomethacin, sodium salicylate and aspirin, 10(-7) M bradykinin significantly decreased the contractility. From these data, we concluded that in ureter bradykinin decreases contractility via a mechanism not involving prostaglandin generation.

Animals↗
PubMedDate not supplied

Lung-volume reduction in parallel with coronary heart surgery: a case report.

For patients with severe disabling emphysema, lung-volume reduction surgery has recently been introduced as an alternative to transplantation. Performing parenchyma resection from appropriate areas can improve pulmonary functions in selected patients having severe emphysema with a flattened diaphragm. We report the case of a patient, who urgently needed coronary revascularization and was otherwise inoperable because of severe chronic obstructive pulmonary disease (COPD). We carried out lung-volume reduction surgery at the same time as the coronary bypass.

Colitis, Ischemic↗