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Biomedical subjects

M Ericsson

Publications and source records attributed to M Ericsson.

At least 91 records · Page 5Linked to original sources
PubMed1981

Lack of suppression of insulin secretion by exercise in patients with insulinoma.

Serum glucose, insulin and glucagon concentrations were measured in three patients with insulin-producing tumours of the pancreas while performing an exercise test. In contrast to the normal adrenergic inhibition of insulin release in response to exercise, plasma insulin concentration remained at a constant and high level during exercise in patients with insulinomas. Their plasma glucose concentrations fell during exercise and in the post-exercise period. No significant changes occurred in plasma glucagon concentration. An exercise test may be a useful new diagnostic tool in organic hyperinsulinism.

Adenoma, Islet Cell↗
PubMed1981

Evaluation of the continuous thermal dilution technique for measurement of coronary blood flow.

A continuous thermodilution technique has been used in a flow model. It has been difficult to determine the exact flow, but alterations of the flow have been reliably determined. For in vivo measurement the catheter is inserted into the vein of the actual organ. The indicator is injected against the bloodstream with a constant speed. The temperature of the indicator and the fall of blood temperature during the injection of indicator are measured with thermistors located at the catheter. The inability to measure the exact flow was mainly due to three factors; it turned out to be difficult to obtain the total and uniform mixing between the "blood" of the flow model and the indicator. Heat leakage occurs within the catheter as well as to ambient structures. The Wheatstone bridge was found not to be suitable, and a new type of instrument for determination of changes of resistance in the thermistors was used.

Catheterization↗
PubMed1980

VIP occurs in intrathyroidal nerves and stimulates thyroid hormone secretion.

Vasoactive intestinal polypeptide (VIP) is known to have powerful effects on the secretion from several endocrine and exocrine glands, and occurs in nerves with a ubiquitous distribution in the body. This infers that neuronal VIP may be a regulator of such secretion, and there is evidence that it is involved in the regulation of exocrine pancreatic function. Previous studies have shown that adrenergic and cholinergic nerves participate in the regulation of thyroid hormone secretion. We describe here combined immunohistochemical and immunochemical studies which show that the thyroid of several species is supplied with VIP-containing nerve fibres that surround blood vessels and run between and along thyroid follicles and that in the mouse neuronal VIP participates in the regulation of thyroid hormone secretion through a mechanism that is mediated by cyclic AMP.

Animals↗
PubMed1980

A gas chromatographic technique for determination of blood flow and metabolism in individual organs (with special reference to the heart).

A method for determining blood flow, oxygen uptake and carbon dioxide release in individual organs is presented. For blood flow measurement an inert gas (N2O) technique was used. Blood contents of O2, CO2 and N2O were measured by a gas chromatographic method with use of a special vacuum chamber for extracting the gases from blood. There was a strong correlation between the contents of O2 determined by the gas chromatographic and a spectophotometric method (correlation coefficient 0.953). Good agreement was found between CO2 in gas samples analysed by the Scholander technique and by the gas chromatographic method. A correlation coefficient of 0.998 was obtained between the N2O content calculated theoretically and that determined by the gas chromatographic technique. The new technique presented makes it possible to calculate blood flow in ml/100 g tissue/min, O2 uptake and CO2 production in an individual organ, whereby the predominant type of metabolism in the organ can be ascertained.

Blood Gas Analysis↗
PubMed1979

On the relation between peripheral atherosclerosis and serum lipoproteins.

The occurrence and degree of peripheral atherosclerosis in 30 male patients with symptoms of intermittent claudication were studied by arteriography. The changes observed in the angiograms were codified. In all patients the concentrations of triglycerides and cholesterol were determined in whole serum and in the three major lipoprotein classes--very low density, low density and high density lipoproteins. These data were compared with those of a control material and were also correlated to the codified angiographic findings in each individual patient. Positive significant correlation was not found between the arteriographic changes and the serum concentrations of lipids and lipoproteins, which might be explained by an advanced stage of the disease where such relationships might not appear.

Adult↗
PubMed1979

Hyperparathyroidism--a life-threatening disease in 1978. A case report.

In a patient with hyperparathyroidism (HPT) two neck explorations with identification of three normal parathyroid glands were carried out. Cervical and mediastinal vein catheterization with blood sampling for determination of parathyroid hormone (PTH) confirmed drainage of large amounts of PTH to a mediastinal vein. Two thoracic explorations were negative anterior and posterior mediastinum). The operations were performed during 1971 and 1978 and extensive, progrediating decalcification with brown tumour formation was radiologically demonstrated during that time. Diminished renal function, skeleton pain and mental depression necessitated a last exploration, at which a 2 cm large parathyroid adenoma was found in the left carotid sheath just below the left mastoid process. The adenoma was drained into mediastinal veins through long anastomotic branches.

Adenoma↗
PubMed1978

Relation between triglycerides in human skeletal muscle and serum and the fractional elimination rate of exogenous plasma triglycerides.

Muscle triglycerides, serum lipid and lipoprotein concentrations and an intravenous fat tolerance test were determined on thirteen survivors of myocardial infarction and on fourteen subjects referred to a Lipid Clinic but without myocardial infarction. The mean concentration of triglycerides in muscle and the fractional removal rate k2 of intravenous injected Intralipid were similar in patients with and without MI. In seventeen of these subjects type IV hyperlipoproteinaemia was found. In type IV patients the muscle triglyceride concentration was twice that found in patients without hypertriglyceridaemia. A negative correlation between muscle triglyceride concentration and the k2 value was found for all subjects with a correlation coefficient of -0.62 (P less than 0.001). No independent correlations were found between muscle triglyceride and serum triglyceride concentration or the triglyceride concentrations of the major lipoproteins.

Adult↗
PubMed1978

Somatostatin inhibits thyroid hormone secretion induced by exogenous TSH in man.

The effect of somatostatin on thyroid hormone secretion stimulated by TSH in man was studied. The injection of TSH into a thyroid artery during surgery was followed by an increase in the serum concentration of iodothyronines in the corresponding thyroid vein. This increase was significantly lower (p less than 0.02) when somatostatin was given as a bolus injection into a peripheral vein 5 min prior to the administration of TSH, and followed by a continuous infusion for 60 min. Since somatostatin-like immunoreactivity has been localized to some cells of the thyroid gland being in a parafollicular location, it is suggested that somatostatin may be an intrathyroidal regulator of thyroid activity in man.

Adult↗
PubMed1978

Secondary hyperparathyroidism combined with uremia and giant cell containing tumor of the cervical spine. A case report.

A 47-year-old woman with chronic pyelonephritis since 1950 was prepared for hemodialysis or kidney transplantation. Investigation disclosed secondary hyperparathyroidism and an osteolytic lesion in C VII and Th I causing a subluxation. There were minor neurological symptoms and apparent risk of luxation of the cervical spine with resulting injury to the spinal cord. Operation was performed with total parathyroidectomy and excision of the bone tumor, followed by fixation of the cervical spine with bone graft. There were no major complications during the postoperative period and the patient was mobilized four months after the operation.

Cervical Vertebrae↗
PubMed1977

Detector electrode introduced by mediastinoscopy for atrial triggered cardiac pacing. A follow-up of electrode function in 82 patients.

An atrial detector electrode was introduced by mediastinoscopy in 82 patients requiring permanent cardiac pacing. There were no complications. An adequate P wave was recorded in 80 patients. During the following week, the P wave became ineffective in 5 patients; angina occurred in 2 and atrial arrhythmias in 2. Atrially triggered ventricular pacing established in 73 patients and was followed in 71 patients for a period of 1 to 113 months. In 17 cases, it had to be terminated because of an ineffective or unstable P wave,in 6 cases because of atrial arrhythmias, and in 4 cases because of advanced age and recurrent infections. The method is technically simple and place little stress on the patient.

Adult↗
PubMedDate not supplied

Fatty acid turnover in the ischaemic compared to the non-ischaemic human heart.

Cardiac extraction, oxidation and release of plasma free fatty acids (FFA) was measured by coronary sinus catheterization, utilizing infusions of 3H palmitate and 14C oleate, in patients with ischaemic heart disease (IHD) at rest and during pacing induced angina pectoris and, for comparison, in healthy men of similar and younger age and men with hypertriglyceridaemia (HTG). At rest IHD patients differed from healthy men only by greater cardiac fatty acid release, which correlated with a significant glycerol release. In IHD patients, unlike in healthy men, myocardial extraction of both palmitate and oleate decreased while fractional oxidation of oleate increased during pacing. Fatty acid release was unaltered. Men with HTG had at rest higher myocardial FFA extraction than IHD patients, which did not decrease during pacing, but like in the patients oleate fractional oxidation increased on pacing. It is concluded that, in the moderately ischaemic human heart, the restricted blood flow may contribute to limit the fatty acid flux into the myocardium. The augmented cardiac fatty acid release in IHD patients is not related to ischaemia per se but may derive from an increased amount of cardiac interstitial fat.

Adult↗